Search PubMedSearch

Biomedical subjects

A V Suprun

Publications and source records attributed to A V Suprun.

At least 19 recordsLinked to original sources

[The clinical picture and pathogenetic problems in low-pressure glaucoma].

Dynamic examinations of 78 patients with a primary diagnosis of glaucoma with low intraocular pressure and 25 persons without disturbances in intraocular pressure regulation, using up-to-date adequate methods--ultrasound dopplerography, rheography, fluorescence angiography, electron tonography, as well as other traditional methods, allow to make a conclusion that glaucoma with low intraocular pressure is a variant of the development of a typical open-angle glaucoma complicated by involutional changes in the body in a form of chronic vascular deficiency (chronic ischemic neuropathy of the eye). Glaucoma with low pressure should be differentiated from ischemic neuropathy or its outcome. The criterium for a diagnosis of low pressure glaucoma is the presence of changes in hydrodynamic and their progression (intensification of retention in reduced level of intraocular fluid outflow), positive results of unloading tests. A term "primary open-angle glaucoma, chronic vascular deficiency" is proposed.

Aged

Change of histochemical and electrophysiological values of rabbit retina due to the antihypoxant sodium hydroxybutyrate.

This paper presents the results of an electrophysiologic and histochemical study on the effect of sodium hydroxybutyrate applied perorally as 5% syrup for 20 days on the rabbit retina. It was found with statistical significance that in response to the drug the amplitudes of "a" and "b" waves of the electroretinogram increased considerably and the activation of some dehydrogenases, glucose-6-phosphatedehydrogenase and lactatedehydrogenase in particular took place; this was most pronounced in the ganglion and in the inner nuclear layers of the retina. The results of the study show that a prolonged peroral application of 5% sodium hydroxybutyrate syrup might be an expeditious way to activate energy processes in the retina.

Animals

Effect of the antihypoxant-sodium hydroxybutyrate on visual functions and oxidative processes in glaucoma patients.

This paper presents the results of the application of sodium hydroxybutyrate as 5% sugar syrup for the treatment of glaucoma patients. Common ophthalmological investigation methods and the oxyhemography were used. Fifty-two primary glaucoma patients (99 eyes) in various stages of disease and with different intraocular pressure levels were investigated. It was found that due to sodium hydroxybutyrate in 36 patients (69%) with statistical significance the visual field limits enlarged; in 15 patients visual acuity improved. The drug was efficient in the initial and developed glaucoma with normalized ophthalmotonus level. Significant improvement of the oxygen metabolism--oxygen saturation level of arterial blood and compensatory mechanisms functions of oxygenation-reduction processes in the majority of the patients was found. On the ground of the obtained findings the authors make a conclusion about the expediency of including 5% sodium hydroxybutyrate syrup in the complex treatment of primary glaucoma patients.

Adult