Biomedical subjects
Publications and source records attributed to A V Roshchin.
The effect of microwaves on liquid water was investigated by using biosensors and physiochemical techniques, such as nuclear magnetic resonance (NMR) and spectrophotometry. The results obtained provided evidence for a nonthermal effect of microwaves on liquid water.
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Features of metal's co-action according to the results of toxico inetic studies concerning the binary elemental combinations infused into the body are discussed. The investigations revealed that the stoichiometric laws of metals' co-action depended on the way the metals were infused by and the scheme of their combined action, on their qualitative and quantitative composition. The quantitative changes in the metabolism of metals during their co-action were found the most important. These changes may serve to evaluate and forecast the combined action of metals. The role of individual metallic qualities in their metabolic co-action was proved to be important.
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From the point of view of modern bio-coordination chemistry the study of metal toxicokinetics showed that changes in metal metabolism within biological media under their combined body intake were closely related to their competition for biologic ligands. Formation of readily and hardly soluble metal complexes, governing their behavior in biologic media, depended not only on ion charge, range, and hydratation energy but also on rigidity and softness of interacting compounds. The constant of each element was also significant in metal competition for bio-ligand capture. It was proposed to use a complex of physical and chemical characteristics of metals in toxicokinetics prediction under their combined body intake.
Toxicokinetics of cobalt was studied on rats by the method of radioactive isotopes using single or repeated administrations. Co was used in the form of sulphate in doses of 0.1 and 0.2 mg/kg administered by 4 different routes (intragastric, intraperitoneal, intratracheal, subcutaneous). Good absorption was established in the parenteral routes of administration, the regularities of absorption, retention in the internal organs and elimination of cobalt were determined and mathematically expressed. Clear dependence was established between the doses administered and the content in biomedia. The liver and the kidneys were found to be the organs of highest accumulation of cobalt. Elimination half-lives and the time of establishment of a constant level during long-term exposure were determined. It is proposed to carry out diagnostic examination in the course of a few hours after the work shift. Urine and blood are the test objects in which direct correlation has been established. Delayed elimination of cobalt from the organism under protracted exposure may be the essential cause of increased hazard for man, which conditions the necessity of determining maximum acceptable concentration for this substance.
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