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Biomedical subjects

A V Persson

Publications and source records attributed to A V Persson.

61 records · Page 4Linked to original sources

Acute arterial occlusions.

We believe that streptokinase is safe and effective in restoring the patency of arteries that have been acutely occluded by thrombosis or embolization. It should be used on those patients in whom the branches as well as the main conduits are occluded. It should also be used when the risks of surgery are great because of concurrent medical problems. Streptokinase should not be used after major surgery, in patients with blood dyscrasias, or when there are neurologic deficits secondary to the arterial ischemia. Streptokinase should not be considered as an antagonist to arterial surgery with the use of the Fogarty catheter but as an adjunct to the ever increasing armamentarium of the vascular surgeon.

Acute Disease↗

Vagal body tumor: paraganglioma of the head and neck.

Vagal body tumors (VBTs) are rare tumors of the paraganglion cells of the vagus nerve, usually occurring near the ganglion nodosum. They can be familial, multicentric, malignant, and sometimes hormonally active. The most accurate diagnosis is made by angiography. Primary treatment is surgical excision. Radiation therapy may play a role in preoperative preparation or in palliation. The prognosis is good when the tumor is found early and completely resected. Lifelong follow-up of patients and their family members is recommended.

Cranial Nerve Neoplasms↗

Importance of valvular incompetence after acute deep venous thrombosis.

The color Doppler scanner was used to analyze acute deep venous thrombosis in 14 patients. A thrombus was found in the superficial femoral vein in 4 patients and in the superficial femoral and popliteal veins in 6 patients; a popliteal occlusion was found in 4 patients. All 14 patients were treated with intravenous heparin followed by at least 3 months of warfarin therapy. Patients were re-examined between 24 and 48 months. Six patients were symptomatic; 8 were asymptomatic. Five patients had occluding thrombus in the distal popliteal vein; major competent collateral channels developed from the proximal superficial femoral vein, and they remained asymptomatic. Three patients whose superficial femoral veins recanalized without valvular incompetence were asymptomatic. Valvular incompetence was observed in all of the symptomatic patients. Patients with persistent popliteal occlusion and collateral channels have fewer symptoms than patients with valvular incompetence in the superficial femoral and popliteal veins.

Adult↗

Clinical application of electrical impedance for the study of arterial insufficiency.

A four-electrode impedance plethysmography containing a dedicated computer has been developed for evaluating arterial insufficiency in the clinical noninvasive vascular laboratory. Measurements obtained by the impedance plethysmograph were compared with measurements obtained by the Doppler ultrasound technique. Five case reports demonstrate that electrical impedance measurements can feasibly be obtained in the clinical setting and that the information is useful in treating patients with arterial insufficiency. Results indicate that electrical impedance data correlate better with the clinical symptoms reported by the patient than do the Doppler systolic pressure data. The impedance plethysmography measurements are particularly useful when considered in conjunction with the Doppler measurements.

Adult↗

Noninvasive evaluation of the aorto-iliac segment.

Eighty-five patients (169 limbs) were studied in the Noninvasive Vascular Laboratory at the Lahey Clinic as part of a preoperative evaluation for arterial insufficiency. Segmental Doppler systolic pressures and peak velocity waveform analysis using a directional Doppler were performed on all patients. Normal velocity waveforms demonstrated forward flow during systole, reverse flow during the first half of diastole and a return to forward flow again during the latter part of diastole (triphasic flow). Significantly abnormal waveforms did not demonstrate reverse flow during the first half of diastole (monophasic flow). A significantly abnormal angiogram showed a greater than 50% stenosis in the aorto-iliac segment. A comparison of Doppler velocity waveforms with arteriograms showed a 96% correlation. Most errors in our study were technical; related to the assumption that the inguinal skin crease marked the location of the inguinal ligament and the origin of the common femoral artery. In these instances, the superficial femoral artery not the common femoral artery was sampled. Common sources of false positive studies were severe outflow obstruction or recent surgery to the common femoral artery, both showing a loss of laminar flow and a monophasic waveform. Patients who demonstrate reverse flow in the common femoral artery by directional Doppler examination had adequate inflow to support a femoral-popliteal or femoral-femoral by pass graft. Patients with monophasic flow had either inadequate aorto-iliac segments, recent surgery to the common femoral artery or severe outflow obstruction. Supportive data will be presented in detail.

Angiography↗