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Biomedical subjects

A V Pavlov

Publications and source records attributed to A V Pavlov.

18 recordsLinked to original sources
PubMed1992

[The mitotic activity of the follicular and parafollicular (C) cells in the thyroid of rats with hypercalcemia].

Slices of the thyroid gland were impregnated with silver nitrate and stained with hematoxylin. Separate calculation of the index of calchicin mitosis of the follicular and parafollicular (C-) cells was made. The material of 37 mature albino rats was analyzed. Calcium-rich diet was given to 22 animals during 10 days. Different levels of hypercalcemia were achieved by different doses of vitamin D2 (from 1 to 10 thousand MU daily, 11 experimental groups). The mitotic index of C-cells was found to grow but under mild hypercalcemia (10% of the control level). Further elevation of the calcium concentration in blood was followed by a decrease of the amount of the dividing parafollicular cells down to control values. In rats fed by the diet optimal for the stimulation of C-cells division (11 rats, 2000 MU as a daily dosage of vitamin D2) within the interval from 1 to 10 days increased mitotic activity of the follicular cells was found from the 3rd day, while that of C-cells only as late as the 9th-10th day. In all the experimental rats the mitotic index of the follicular thyrocytes was 3.5-4 times as high as the mitotic index of C-cells. Relatively not high proliferative activity of parafollicular cells might be due to their pronounced polyfunctional character and their participation in complex paracrine interactions with other cell elements of the thyroid gland.

Animals↗
PubMed1991

[Protection from foot-and-mouth disease virus in naturally-susceptible animals by a linear polymer of a synthetic peptide].

Linear polymer of a peptide corresponding to the fragment 142-155 of the foot-and-mouth disease virus A22(550) protein (VP1) was synthesized. Whereas the monomeric peptide was only slightly immunogenic, the polymer induced virus-neutralizing antibodies in rabbits and protected 100% guinea pigs. Sheep vaccinated once and cattle vaccinated twice were stable against infection with the homologous virulent foot-and-mouth disease virus.

Amino Acid Sequence↗
PubMed1978

[Reparative processes in the liver and adrenal cortex of rats following an experimental vascular crisis].

Reparative processes in the liver and the adrenal cortex of hemiadrenalectomized female rats, which sustained an acute circulatory disturbance as a result of orthostasis, were investigated by means of quantitative methods (cytometry, kariometry, nucleolometry, determination of cell content calculation of nucleo-cytoplasmic, nucleolo-nuclear ratios). Common features in regeneration of the organs under study were found. During the first days of the experiments the count of the dying cells increased and simultaneously the quantity of amitoses and binucleated cells in the liver grew. The cell composition of the organs was stabilized by the 15th day in the adrenal gland and by the 45th day in the liver. During the first week after orthostasis mitotic activity of epithelial cells rose in both the organs. Later the regeneration took place at the intracellular level (activation of the nuclear apparatus and hypertrophy of the cell cytoplasm).

Acute Disease↗
PubMed1978

[Cellular composition of different zones in the rat and rabbit hepatic lobule under normal and experimental conditions].

Different types of hepatocytes (with caryopycnosis and caryolysis, at the state of mitosis, with amitotic nuclear strangulation and with two nuclei) were counted in the central, middle and peripheral zones of the hepatic lobule in rats subjected to an acute aminosin intoxication, and in rabbits after compressing soft tissues of the extremities. Time of observation--1--90 days in the rats and 10 h--20 days in the rabbits. In the zones of the hepatic lobule with the greatest degree of damage, the number of cells with caryopycnosis and caryolysis, as well as the number of hepatocytes with amitotic nuclear strangulation and binucleated cells were especially great. Mitotic activity of the hepatic cells was about 0.49% in the rats and 0.07% in the rabbits. Regardless the place of the damage in the hepatic lobule in all the zones, there was a definite correlation between the amount of cellular forms reflecting the demage and destruction of hepatocytes and their restoration, the same as observed in certain zones of the intact hepatic lobule.

Acute Disease↗
PubMed1977

[Ocular scale for logarithmic grouping of classes of spherical nuclei and measurement of the diameters of their nucleoli].

The proposed scale is prepared by a photographic method and consists of some vertical lines, each of them being disposed at the distance equal to a nucleus diameter having bordering size between classes of lg mkm2, and of three horizontal lines, forming two patterns designated for measuring diameters of nucleoli. The scale is meant for working with the objective 90 X and the ocular 20 X and makes the measuring of nuclei and nucleoli diameters 2--2,5 times quicker as compared with the screw ocular micrometer with a sufficient coincidence of results, obtained by both methods.

Cell Nucleolus↗
PubMed1975

[Epidemiological patterns of the import and spread of El Tor cholera].

The paper is a response to the paper by A. K. Akiev published in 1974 in the "Journal of Microbiology Epidemiology and Immunobiology": "Concerning the Epidemiology of El Tor cholera Abroad". The opinion of the author concerning the origin of El Tor infection in 1970, the sources of infection, and the factors of its transmission is critisized. Literature data and personal observations explaining the regularities of importation and spread of El Tor cholera as an intestinal infection are presented; these data are against the view of Akiev on El Tor cholera as a disease with a natural nidality caused by freely living vibrios.

Asia, Southeastern↗
PubMedDate not supplied

[Thyroid morphofunctional changes in various types of experimental chronic stress].

Structural and functional parameters of the thyroid were studied in mature rabbits, inducing stress by stimulating the ventromedial nucleus of the hypothalamus or by exposing the animals to electrocutaneous irritations. Morphometric and radioimmunoassay results have revealed thyroid activation during the adaptation syndrome. Prolonged intensive stress was shown to cause a decrease in thyroid secretory activity, reflecting change of a stage of stable resistance by a phase of depletion of compensatory resources. However the nature of changes in the blood levels of thyroid and thyrotropic hormones in experimental animals have some characteristic features. A conclusion was made of the correlation between pathogenesis of the general adaptation syndrome and a methodological approach to simulation of a body tension reaction.

Adaptation, Physiological↗