Biomedical subjects

A V Paranich

Publications and source records attributed to A V Paranich.

At least 19 recordsLinked to original sources

PubMed2000

[The effect of wheat germ oil on the antioxidant system of animals].

An experimental study was made on wheat-germ oil as a source of easily assimilable vitamin E. In rats, the above oil intake results in a rapid increase in the content of vitamin E in the brain, liver, heart, lungs, kidneys, and spleen. There has been studied a change in the intensity of lipid peroxidation processes. It is shown that in oral administration wheat germ oil efficiently saturates the body with vitamin E. In all tissues, the work of the [symbol: see text]-tocopherol redox-system is noted to be stimulated, LPO inhibited, with eicosanoid synthesis proceeding under immediate control of the system of fat-soluble vitamins. The total state of dynamic equilibrium in the LPO-AOA system has effectively shifted to the side of predominance of the AD system components. The total tissue AOA remained stable in most organs.

Animals↗

PubMed1999

[The effect of ultraviolet on the structural-functional characteristics of mouse thymocytes].

The changes of peculiarities thymocytes membranes after the UV actions on the suspension cells were investigated. The POL intensivity; content the carotene, vitamins A,E and its metabolites were determined. The state of membrane lipids and proteins was observed by fluorescent zondes. After 15 min of UV action form of the humoral activity products of POL was increased; the redox system of vitamin E was mobilized; the membranes proteins was opened; the neutral lipid fraction in membranes was decreased, and its polarity was increased. After 25 min of UV action was observed: the stimulation of the first and second steps of POL; decreased of AO activity; more opened of membranes proteins; more increased of polarity lipids and reform of lipofility of membranes. This changes lay in the base of activity and passivity of thymocytes by UV.

Animals↗

PubMed1998

[The protective action of tocopherol acetate in simultaneous administration with nitrobenzene and its chloro derivatives].

In experiments in albino rats, effects were studied of nitrobenzene and its chloro derivatives in intragastric administration with tocoferolum acetatum. Changes in the process of lipid peroxidation in blood serum, liver, and spleen which were characteristic of xenobiotics themselves have been shown to be less pronounced in this setting. Tocoferolum acetatum being administered at the same time is actively drawn into the metabolism. Normalization of the antioxidant activity of the tissues under investigation was to be observed, with lipid peroxidation and the antioxidant system being in equilibrium. Tocoferolum acetatum administered with xenobiotics has been shown to have a protective action. Tocoferolum acetatum is recommended to be included into diets for workers engaged in chemical industry on a prophylactic basis.

Administration, Oral↗

PubMed1996

[The antioxidative activity of homogenates and lipids obtained from intact and ischemic organs in rats].

The antioxidative activity of homogenates and lipids isolated from the brain, heart and liver was studied. The model of thermal autoxidation of linetolum in the presence of specimens studied was used. The antioxidative activity of lipids from the heart is higher than that of lipids from the brain. Ischemia of the organs leads to a practically complete loss of these qualities. The contribution of lipids to the general antioxidative activity of the tissue depends on the organ peculiarities. The contribution of lipids from the brain to the general activity is almost 10 times higher than that of lipids from the liver.

Animals↗

PubMed1993

[The action of nitrobenzene and its chlorine derivatives on the indices of antioxidative homeostasis in rat tissues].

The authors studied the rate of lipid peroxidation, antioxidative activity and content of vitamin E in the liver and spleen of rats given nitrobenzene, o-nitrochlorbenzene and p-nitrochlorbenezene. The xenobiotics increased LPO, antioxidative activity (AOA), splenic levels of vitamin E. The subchronic influence of the substances led to stabilization of LPO, changes in the activation of the body's adaptation. The AOA and vitamin E play an important role in the regulation of antioxidative homeostasis.

Animals↗

PubMed1992

[Lipid peroxidation following ultraviolet irradiation of the blood and the protective action of tocopherol acetate (experimental research)].

Original experimental data are reported on processes occurring in the blood after UV irradiation. A study of the content of primary and secondary products of lipid peroxidation, vitamin E and the resistance of erythrocytes to hemolysis, catalase activity before and after UV irradiation of animals of different age groups revealed that UV irradiation of the blood changes not only the intensity of the process of lipid peroxidation but also the direction of metabolism of unsaturated fatty acids in the blood cells, exchange of semiproducts between them and the plasma, but also weakens the antioxidant systems of the blood. These processes are age-dependent. Preliminary administration of vitamin E preparations secures a high antioxidant homeostasis in the blood, especially after UV irradiation.

Aging↗

PubMed1991