Biomedical subjects

A V Makhnev

Publications and source records attributed to A V Makhnev.

3 recordsLinked to original sources

PubMed2004

[The specific features of malaria clinical course debut in servicemen arrived in tropics from non-malariogenic regions].

The specific features of initial period of vivax and tropical malaria were defined with the help of clinical-and-laboratory methods in two groups of servicemen (70 persons in each group) differed by the period of stay in tropics. For comparison 30 similar patients, the tropics inhabitants, were investigated. In local inhabitants the course of all forms of malaria was rather mild with development of disease characteristic paroxysms in most of them. The reverse correlation of disease severity and period of servicemen' stay in tropics was revealed. For both forms of malaria the migrants compared with local inhabitants had the prodromal period and initial fever without typical paroxysms. The following debuts of malaria were revealed in servicemen: the frequent (influenza-like, arthralgia-like, gastrointestinal, bronchopneumonic, typhoid-like) and the rare (abdominal and painful, cerebral: meningeal and comatose, dysentery-like, tuberculosis-like, hemorrhagic). The shown features of malaria initial period in servicemen caused difficulties in its early diagnosis.

Adolescent↗

PubMed1996

[Respiratory system involvement in pseudotuberculosis].

Clinical, microbiological, x-ray and immunological examinations of 1376 patients with pseudotuberculosis and 465 patients with acute respiratory diseases of viral or coccal origin, the trends in annual morbidity for the above diseases followed up within 7 years in the populations where the patients were registered and experimental investigations on rabbits provided evidence for primarily generalized pattern of pseudotuberculosis infection and a direct relationship between pulmonary lesions in the animals and effective dose of the infectant, route of the infection. The patients had nonspecific (non-yersiniosis) lesions of the respiratory system. Frequency of the infection was greater in cold seasons, especially in those who did not complete social and biological adaptation to new conditions, and depended on seasonal fluctuations of respiratory infection morbidity in nonrandom populations.

Acute Disease↗

PubMedDate not supplied

[Characterization of the foci of meningococcal infection in closed groups of males].

A total of 257 foci of meningococcal infection in groups of servicemen were selectively examined in 1982-2002. From these groups 353 patients with generalized forms of the disease underwent hospitalization. Most of the foci had a single infection, the proportion of foci with 10-40 patients was 82.6%. The meningococcal infection rate among humans in the foci was 25-37%, group A meningococci playing the leading role. In the structure of meningococcal infection generalized forms of infection constituted 16%, localized forms constituted 25% and inapparent forms (carriers)--59%. The formation of the morbidity structure was influenced by the type of the focus (with a single or multiple infection) and the character of morbidity for many years (during epidemic or at the period between epidemics). No absolute dependence of the level of meningococcal carrier state in the groups of servicemen on the appearance of the generalized forms of meningococcal infection was noted. Thus, both during epidemic and at the period between epidemics the population of meningococci, heterogeneous in its serological structure and differing in its clinical and epidemiological importance, constantly circulated with the leading role played by group A meningococci.

Carrier State↗