[Intestinal dysbacteriosis: current aspects of studying the problem, principles of diagnosis and treatment].
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Biomedical subjects
Publications and source records attributed to A V Dubinin.
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A significant correlation between development of colonic polyps and long-lasting irritable colon syndrome was established. However, within the time interval studied (13-15 years), polyps which were mostly true adenomas did not turn malignant.
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The possibility of detecting propionic acid-producing bacteria in the intestine of healthy humans with a view to obtaining a strain which is physiologically most suitable for therapeutic purposes has been studied. The selective conditions for the isolation of propionic acid-producing bacteria from the large intestine have been experimentally established. Analysis of 70 puncture biopsy specimens of parietal mucus and luminal contents from different sections of the intestine has not shown the presence of the representatives of propionic acid-producing bacteria. The strains isolated under the conditions selective for such bacteria have been found to belong to the family Enterobacteriaceae. These strains have proved capable of synthesizing vitamin B12, but the synthesis of propionic acid has not been observed.
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The authors present the preliminary results of double daily irradiation with a 4-hour interval of patients with rhinopharyngeal cancer (30 persons) and lymphosarcoma (18). This irradiation variant was well tolerated; all the patients received radiotherapy in accordance with the plan of irradiating tumors with mean focal doses of 70-76 Gy for rhinopharyngeal cancer and 40-50 Gy for lymphosarcoma. Complete tumor regression by the end of radiotherapy was achieved in 75%, partial in 25% of patients with rhinopharyngeal cancer. In lymphosarcoma, these figures were 80 and 20%, respectively. No late injuries of the normal tissues after 6-36 months were noted in patients.
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