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Biomedical subjects

A V Chuprova

Publications and source records attributed to A V Chuprova.

7 recordsLinked to original sources
PubMed1991

[Role and physiologic importance of thrombinemia in healthy newborns].

The sensitive orthophenanthroline test was used to reveal paracoagulation in 27 normal newborns, thrombinemia reaching the highest level at the moment of birth and in the period of heavy depression of blood coagulation (on the fifth day of life) was detected. It has been suggested that the physiological role of thrombinemia is in the leveling of hypocoagulation shifts and providing of the local hemostasis. To escape thrombotic complications, drug correction of the hypocoagulation physiological level (activity of prothrombin complex factors is 30-60%) is not recommended.

Humans↗
PubMed1990

[Clinical significance of Willebrand's factor in allergic dermatoses in children].

An original micromethod for assaying Willebrand's factor (WF) was used to measure the content of the protein in 45 children with different allergic dermatoses. WF measurement were at the height of the clinical manifestations and during remissions. It has been established that children with allergic dermatoses manifest a fairly appreciable increase fo WF in the plasma, which is likely to reflect objectively the systematic nature and gravity of vascular endothelium derangement. The increase of WF correlates with the gravity of the clinical manifestations of the disease. As the clinical symptoms were being removed, the level of WF was progressively decreasing. Its normalization attests to a genuine arrest of allergic vasculitis. Platelet activation detected in all the forms of allergic dermatoses in the basis for inclusion of antiaggregation agents into those patients' treatment.

Adolescent↗
PubMed1990

[Microtests for evaluating hemostasis and their clinical value].

A system of microtests, adapted for pediatric practice, has been developed, tested, and proposed for practical use. The system includes 13 microtests, 4 of them meet the requirements of a rapid diagnostic test, the others are used as differentiating and specifying. For the first time three levels of the coagulation status have been distinguished in the newborn: physiologic, border and pathologic; this enables orientation in hemorrhagic and thrombohemorrhagic diseases in the newborn. On the basis of the unified microtests the authors have determined the tactics in early diagnosis and follow-up of newborns suffering from hemorrhage treated outpatiently. The diagnosis was verified under dispensary conditions in 158 (66.6%) children with hemorrhagic diathesis. The results of the investigations described are promising for further improvement of the diagnosis and treatment of hemostasis disorders in newborns with the use of the microtests of new generation.

Blood Coagulation↗