Acromegaly is an uncommon disease due to excessive amounts of growth hormone. Benign and malignant tumors have been reported in acromegalic patients. A 41-year-old female patient who had been followed up because of acromegaly by the endocrinology department for two years, was admitted to the hematology department for the evaluation of pancytopenia and the related signs and symptoms. Dopamine agonists were being used till a diagnosis of 'acute promyelocytic leukemia' was made. Occurrence of 'acute promyelocytic leukemia' in the course of acromegaly may have been caused by excessive endogenous GH or may be a coincidental situation.

Acromegaly↗

PubMed1994

Plasma endothelin-1 concentrations in patients with Behçet's disease.

Plasma Endothelin-1 (ET-1) concentrations were determined by radio immunoassay in 30 patients with Behçet's disease at various stages and 20 healthy subjects. Mean ET-1 plasma concentrations were significantly (p < 0.001) increased in patients with active Behçet's disease (35.99 +/- 5.06 fmol/ml, mean +/- standard error) compared to concentrations found in healthy volunteers (10.98 +/- 0.84 fmol/ml). No difference in plasma ET-1 level was observed between patients with inactive Behçet's disease (12.98 +/- 1.14 fmol/ml) and volunteers. Increased plasma levels of ET-1 in patients with Behçet's disease may be attributable to increased secretion or leakage of this mitogen from injured vascular endothelial cells. These results indicate that ET-1 may play an important pathogenetic role in the development or progression of vasculitis common to Behçet's disease. Plasma concentrations of ET-1 correlates with the activity of illness.

Adult↗

PubMed1994

A case of HB J-Meerut (or Hb J-Birmingham) [alpha 120(H3)Ala-->Glu].

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Adult↗

PubMed1992

[Botulism: a case report].

Botulism is an acute form of poisoning that results from ingestion of a toxin produced by Clostridium botulinum. Botulism toxin causes their major effect by blocking neuromuscular transmission in autonomic and motor nerve terminals. Guillain Barre Syndrome, Myasthenia Graves, Lambert Eaton Myasthenic Syndrome, acute poliomyelitis and diphtheria must be considered in the differential diagnosis. Electrodiagnostic studies have been shown to be of value in differentiating botulism from other paralytic diseases. Identification of the toxin in the patients serum is diagnostic. The treatment of botulism is mainly supportive. In this study we have discussed a patient who was treated in our clinic as a botulism from unknown source, the differential diagnosis from other paralytic diseases.

Botulism↗