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Biomedical subjects

A Tsanev

Publications and source records attributed to A Tsanev.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Multiple gangrene of the digits in a female patient with liver cirrhosis, diabetes mellitus and cryoglobulinemia].

A case is described with multiple gangrene of the fingers of a female, aged 55, with confirmed cirrhosis of liver and diabetes mellitus. Cryoglobulins were established in the serum. A disturbed immunological balance was present and the family loading with collagenosis raises the problem of genetic moments of the disturbed homeostasis. The existing diabetic microangiopathy, histologically confirmed by biopsy of skin and subcutaneous tissue, brings forward the question of the complex pathogenesis of gangrene. At the end of her stay in the clinic, the patient developed cerebral apoplexy.

Brain Ischemia↗
PubMed1985

[Lipoatrophic diabetes with hypertrophic subaortic stenosis].

A rare case is described of the combination of lipotrophic diabetes with hyperrophic subaortic stenosis in a young female. The authors announce the good results from the administration of bromorgocryptin for the reduction of the considerable hyperlipoproteinemia in the patient. The scare experiences in literature from the administration of the preparation is emphasized as well as the difficulties in the explanation of its mechanisms of action, at the present stage of our knowledge.

Adult↗
PubMed1985

[Informative significance of hemoglobin A1 in the control of diabetes].

Sixty one patients were studied, 23 with diabetes, type I and 38 with type II. The level of glycosilized hemoglobin was determined in all, corresponding to the routine battery of symptoms and laboratory data, used in the practice in the evaluation of the state of the diabetic patients. A low correlation coefficient was established (type I r = 0,1 and type II r = 0,1) between the calculated glucose and mean blood sugar from blood sugar profiles. Glycohemoglobin level under and over 10% was established both in patients with increased and normal blood sugar. The use of the routine control methods gave no possibility of objective evaluation for the state of metabolic diabetic disorders in all patients. The determination of glycosilized hemoglobin presented a possibility of obtaining unique information on metabolic compensation of diabetes and the effectiveness of the treatment applied.

Adult↗
PubMed1985

[Use of the artificial endocrine pancreas in the clinic].

Via the artificial endocrine pancreas--apparatus "BIOSTATOR" 100 patients were studied and treated, namely: 90 with diabetes mellitus, 7 with hyperinsulinism and 3 with obesity. The 24-h insulin needs of the diabetics with insulin-dependent and non-insulin dependent with secondary exhaustion type of diabetes, were determined. The following subcutaneous insulin dosage was determined, depending on the insulin amount spent during the 24-h biostator control. It was established that the necessary reduction of the intravenously administered insulin is 30% on the average with the passing over to subcutaneous regime. The indices of lipid metabolism were also studied as well as numerous hormones with which the carbohydrate compensation leads to a change. The problem of the "morning" phenomenon is discussed.

Diabetes Mellitus↗
PubMed1984

[Diet in diabetes and obesity].

The interrelations between obesity and diabetes mellitus are discussed. Age type diabetes was established in 80-90 per cent of all diabetics. 80-90 per cent of them being with overweight. On the other hand, the incidence of latent and manifested diabetes among the patients with obesity is 10 times higher as compared wth the rest of the population. The role of increased insulin secretion is stressed upon as well as the reduced concentration of insulin receptors in the pathogenesis of the reduced glucose tolerance in diabetes. The purpose of dietetic treatment of diabetes, second type, combined with obesity, is to reach the normal body weight. A diet of 20 kcal/kg is recommended for that purpose. The calories of carbohydrates are increased to 55 per cent with the present diet and at the same time, the calories from lipids are reduced to 25-35 per cent. The carbohydrates are taken in the form of polysaccharides, with increased content of fibres. The ratio between unsaturated and saturated fatty acids should be I.

Adipose Tissue↗
PubMed1984

[Dynamics of the serum lipid indices in thyrotoxicosis].

Total cholesterol, HDL-cholesterol, triglycerides, NEFA and phospholipids were studied in the sera, before the treatment, in 45 patients (40 females and 5 males) aged from 14 to 73 with various forms of hyperthyroidism. In 16 of them the studies were repeated about one month after the initiation of the thyreostatic treatment, when the hyperthyroid symptomatics has obviously been controlled. The results obtained about the separate serum lipid indices of the patients were discussed, compared with the data of the control group (n = 14), as well as the role of the low serum HDL-cholesterol and increased triglycerides in the genesis of thyreotoxic cardiomyopathy.

Adolescent↗
PubMed1977

[Functional state of the genital system in men with obesity].

The results from the carried out investigations on fertility indices of ejaculate are reported as well as on the spermatogenic activity test with radioactive phosphorus and on the determination of total gonadotropic excretion in urine of males with high degree of obesity. A statistically significant decrease of all investigated in dices of ejaculate and the test of spermatogenic activity was found. The decreased gonadotropic activity in over half of the patients investigated with obesity, as well as the manifestations of diencephalic alterations in them made the authors admit the secondary character of the gonad disorders.

Adult↗