[Dinitrochlorobenzene in the therapy of alopecia areata. Our clinical experience].
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Biomedical subjects
Publications and source records attributed to A Tosti.
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Available epidemiological data indicate that the prevalence of onychomycosis due to dermatophytes increases with ageing. The aim of this study was to investigate the epidemiology of dermatophyte nail infections in 2 populations selected only on an age basis and to verify whether the presence of onychomycosis was associated with increased exposure to possible predisposing factors. From January to June 1995, the nails of 1,800 military recruits and 253 elderly individuals living in a nursing home were examined. Mycological studies were performed in all cases of suspected onychomycosis. The presence of systemic or local diseases that may favor fungal nail infection as well as exposure to environmental factors were assessed in the 2 populations. Onychomycosis was diagnosed in 8 recruits (0. 44%) and 38 of the elderly people (15%). The presence of onychomycosis was not related to the degree of exposure to environmental factors or to systemic or local diseases.
Primary nail invasion by Candida is uncommon and almost exclusively seen in patients with an impaired immune function. The appearance of Candida onychomycosis in an adult who is not under immunosuppressive treatment always requires a laboratory evaluation of the immunologic function including HIV assays. We report 2 cases of distal subungual onychomycosis due to Candida sp. in HIV. In one of our patients, the diagnosis of Candida onychomycosis preceded the diagnosis of advanced HIV infection. In both of our patients treatment with systemic antifungals produced complete cure of Candida onychomycosis and the 1 year follow-up did not reveal any relapse of the onychomycosis.
Sjögren's syndrome is an autoimmune disease characterised by generalised lymphoproliferation. Patients have an increased risk of developing lymphomas which are usually derived from mucosa-associated lymphoid tissue (MALT). We report a low grade, non-Hodgkin's lymphoma of the skin and oral mucosa in a patient with Sjögren's syndrome.