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Biomedical subjects

A Torres

Publications and source records attributed to A Torres.

At least 775 records · Page 43Linked to original sources

Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung.

The aim of the present study was to analyze the prevalence and clinical importance of p53 gene mutations in surgically treated squamous cell lung carcinoma. Sixty patients were included. Fifty-one patients in stages I to IIIa were submitted to radical resection. Twenty-five samples tested positive for the p53 immunohistochemistry assay, and were analyzed for p53 gene mutations. Eleven mutations were found. Patients harboring p53 gene mutations suffered a higher incidence of recurrence and a higher mortality rate. Disease-free interval and overall survival were shorter for patients with mutated p53 gene (p=0.03 and p=0.005, respectively).

Adult↗

Rural and urban family planning services in the United States.

Family planning programs have become more efficient. It cost $66 per patient in 1976 to provide services in both rural and urban programs--the same cost reported in 1971, despite a 40 percent increase in prices since that time. Rural programs are dominated by health departments, lack health professionals, are more likely to insist teenagers have parental consent.

Adolescent↗

The vasectomized testis.

We have performed a qualitative study on effects of vasectomy on the testicular structure. Vasectomy performed with the traditional technique changes testicular structure. At first, the injuries are slight and restricted, but gradually, and in a time-dependent manner, become more severe and extensive. Ultrastructure studies indicate that the spermatogonia and Sertoli's cells are the most resistant to vasectomy, and are even observed in some regenerating testes lacking a complete germinal epithelium. Morphometric studies revealed a decrease in epithelial depth, an increase in the thickness of the basement membrane and in surface of the interstitial space, all significant (P < 0.01) with respect to the control. However, the percentage of the interstitial tissue occupied by cells, did not show any significant difference. We propose that the increase of intraluminal pressure is the essential factor that provokes testicular atrophy.

Animals↗

[Influence of early stimulation in cerebral palsy].

INTRODUCTION: Early stimulation is known to be useful, necessary treatment aimed at developing as much as possible the social psychophysical potential of any child at high environmental and/or biological risk. This group includes children with cerebral palsy, a disorder of the nervous system which may cause retardation in the processes of maturation of the central nervous system and be expressed from the earliest months of the child's life as retardation of psychomotor development. OBJECTIVE: To show the efficiency of early stimulation in children diagnosed as having cerebral palsy and retardation of psychomotor development. PATIENTS AND METHODS: A retrospective study was made of 20 children aged between 9 and 41 months with this diagnosis, in the hospital of CIREN (Cuba). They were treated for a period of 1 to 3 months by a multi-disciplinary team and participated in the programme for Early Stimulation. Assessment was made by the Neuropsychology Department at the start and end of the treatment period, using the first part of the Brunet-Lezine scale for the measurement of psychomotor development in early childhood. RESULTS: In all patients there was a favorable course and new abilities were acquired. There was better performance than before the treatment was started and accelerated rate of development during the period of treatment. CONCLUSION: Patients with cerebral palsy and psychomotor retardation benefit from application of a programme of Early Stimulation.

Cerebral Palsy↗

[Cognitive deficit and schizophrenia].

INTRODUCTION: In the present paper, the results of a number of different studies that have tried to establish the characteristics of the cognitive deficit in schizophrenia are discussed. The principal objective of this study was to ascertain whether exist statistically significative differences in such deficit in schizophrenic patients in relation with their preponderant symptomathology (positive symptoms, negative symptoms, and disorganization) or their degree of defectual symptoms. METHODOLOGY: Sixty three schizophrenic patients under treatment in a Day Hospital were divided in groups using the dimensions of Liddie and the Scale for assessing the Deficit Syndrome in Schizophrenia. Cognitive deficit was assessed by the Wisconsin Card Sorting Test (WCST). RESULTS: Our results show that education and gender has no relation with the cognitive deficit exhibited, whereas there is a direct relation with age and years suffering the illness. Patients who exhibited preponderant disorganization symptoms and those describes as defectual syndrome schizophrenics showed more cognitive deficit in the WCST. The number of preservations in the WCST seems to be the main deficit. CONCLUSIONS: The concept of planning in suggested as a schizophrenic marker in the frame of theories that claim there is a failure in the neurodevelopment of these patients.

Adult↗

[Stereotaxic microsurgical resection of intracranial tumors guided by imaging and assisted by computer].

INTRODUCTION: The microsurgical techniques for resection of intracranial lesions are limited where anatomical references do not exist or cannot be used as guides in the dissection of deeply located lesions or in more superficial eloquent areas. The stereotaxic guide, guided by imaging gives precise volumetric and geometric definition in intracranial lesions. Its application in the resection of intracranial tumors has special characteristics due to their biological condition and varied localization. OBJECTIVES: Spatial orientation during surgery is essential. We show this application of stereotaxic surgery in the Centro Internacional de Restauración Neurológica (CIREN) in La Havana, Cuba, between May 1994 and February 1988, describing 65 microsurgical operations done using stereotaxis in 62 patients with intracranial cerebral tumors. PATIENTS AND METHODS: The procedure was divided into three stages: acquiring an image, computerized axial tomography and surgical planning, with the STASSIS planning system and microsurgical procedures, including systems of stereotaxis: Leksell, Micromar and Estereoflex. RESULTS: Of the total, 27 of these patients had glial tumors, 33 non-glial tumors and only 2 had non-neoplastic lesions of different sites and sizes. A total of 30 resections were done. Surgical morbidity was minimal and there was no surgical mortality. CONCLUSIONS: The main advantages of this method are: exact localization of the site for craniotomy, easy spatial orientation and ease in distinguishing the delimitation between the tumour and the healthy tissue. It has been shown that Estereoflex may be used in cerebral microsurgery.

Adolescent↗

[Structural peculiarities of the human cerebral communicating arteries and their repercussion in encephalic vascular pathology].

INTRODUCTION: The cerebrovascular accidents are one of the most frequent causes of morbimortality. Most of them are caused for the break of aneurysms in communicating arteries. The weak structure of these vessels explain the reason of these accidents. OBJECTIVE: The reason of this paper is study the organization of communicating arteries as cause of this fragility. Material and methods. The material of this study is composed of 61 human cerebral communicating arteries, grouped in decades. The study has been carried out by histological routine. RESULTS: In general the structure of cerebral communicating arteries is characterized for the thinness and irregularity of the wall. In the childhood the internal elastic membrane and tunica media show thicker, while in young and adult people appear elastic fibers and reticulin as well as smooth muscle cells in tunica media. In adulthood (50 60 years) collagen in adventicia occupies tunica media, and adventicia is weaked. There are frequent media defects in these communicating arteries, that are usually repaired for conjunctive tissue stopper with abundance of collagen fibers. Starting from 4th decade the internal elastic membrane shows a great number of fenestrae through muscle and fiber tissue of media occupying subintimal space. Doubtless media defects mean the most severe threat of vascular outbreak. CONCLUSION: The structural evolution with the age of communicating arteries, with predominance of collagen over elastin and reticulin, could be their reason of fragility.

Adult↗

[Spinal muscular atrophy associated with olivopontocerebellar hypoplasia. A case report].

INTRODUCTION: Spinal muscular atrophy is a frequent neurodegenerative disease in infancy. Nevertheless, its association with olivopontocerebellar hypoplasia is rare. CASE REPORT: We describe a case displaying clinical symptoms that included respiratory failure, dysmorphias, hypotonia, deep tendon areflexia and respiratory complications, like the cases described in the literature. In the genetic study it was not possible to find the motor neuron gene surviving from the infantile muscular atrophy. The neuropathological disorders found in the necropsy study were olivopontocerebellar hypoplasia with intense neuronal loss (fundamentally from Purkinje cells and from the granular layer of the cerebellum, olivary nuclei and pons), replacement gliosis and degeneration of the motor cells in the anterior horn of the spinal cord. Death occurred due to a respiratory complication in the 11th postnatal month. CONCLUSIONS: The paper describes the clinical-pathological study and the genetic study of a female patient who died at the age of 11 months after being diagnosed as presumably suffering from Werdnig-Hoffman disease. The autopsy revealed an olivopontocerebellar hypoplasia, which is a morphological trait that is not associated with the above-mentioned entity. The microscopic study revealed extensive areas of gliosis and neuronal loss. We conclude with the diagnosis of spinal muscular atrophy associated with olivopontocerebellar hypoplasia, which is a rare clinical entity with very few case reports and whose genetic defect is still unknown. We also review the extant literature related to this case.

Abnormalities, Multiple↗

Validation of the Spanish version of the Social Functioning Scale.

INTRODUCTION: Social functioning as an outcome variable in therapeutic interventions with schizophrenic patients has been a relatively neglected area. The Social Functioning Scale (SFS) may be a good instrument to evaluate different therapeutical strategies for the rehabilitation of the schizophrenic patient. The aim of this paper is to validate the Spanish version of the SFS. MATERIAL AND METHODS: The Spanish version of the SFS was administered to 85 patients with schizophrenia (DSM-IV), and 120 healthy volunteers (60 unemployed and 60 employed). RESULTS: Cronbach's alpha is between 0.69 and 0.80 in every subscale. Item-total correlations show higher internal consistency than in the validation of the original English version of the SFS. Factorial analysis suggests it could be appropriate to use a mean score from every subscale to make a total score. Discriminant analysis differentiates between patients and controls in a statistically significant way. In order to facilitate the interpretation of the results and their clinical use, a conversion of the direct scores into standardized ones was carried out. CONCLUSIONS: Results from three samples show that the Spanish version of the Social Functioning Scale is reliable, valid, and sensitive.

Adult↗

[Gender differences in cognitive functions and influence of sex hormones].

OBJECTIVE: To review scientific evidence on gender differences in cognitive functions and influence of sex hormones on cognitive performance. METHOD: Systematical search of related studies identified in Medline. RESULTS: Women outperform men on verbal fluency, perceptual speed tasks, fine motor skills, verbal memory and verbal learning. Men outperform women on visuospatial ability, mathematical problem solving and visual memory. No gender differences on attention and working memory are found. Researchers distinguish four methods to investigate hormonal influence on cognitive performance: a) patient with hormonal disorders; b) neuroimaging in individuals during hormone administration; c) in women during different phases of menstrual cycle, and d) in patients receiving hormonal treatment (idiopathic hypogonadotropic hypogonadism, postmenopausal women and transsexuals). The findings mostly suggest an influence of sex hormones on some cognitive functions, but they are not conclusive because of limitations and scarcity of the studies. CONCLUSIONS: There are gender differences on cognitive functions. Sex hormones seem to influence cognitive performance.

Adult↗

[Behavior of the ST segment, during isometric exercise, in chagasic patients with apical aneurysm of the left ventricle].

In order to study the ST-segment changes during isometric exercise (IE) we have reviewed the hemodynamic and cineangiographic protocols of 13 with Chaga's disease patients. On the basis of the electrocardiogram (EKG) and the left ventricular cineangiogram, the chagasic patients were divided in two groups. Chagas' group I: 6 patients with left ventricular apical aneurysm, Chagas' II: 7 patients with multiple left ventricular dyskinetic segment and occasional premature ventricular contractions. Fourteen subjects with normal left ventricular cineangiograms and normal EKG's were used as controls. The IE was performed by all chagasic and control subjects 31.9 +/- 18 (M +/- SD) months after the cardiac catheterization. The IE was performed at 25% of maximum voluntary capacity for 5 minutes. The precordial leads (V1-V6) were simultaneously recorded, in the standing position, immediately before and after the IE. The ST-segment changes were assessed by measuring the distance of the 'J point, of the ST-segment, to the baseline in three consecutive sinus beats. Immediately before the IE, 5 patients of Chagas' group I (86%) has ST-segment elevation (leadas V1-V2). In the control group, only 2 subjects (14%) had ST-segment elevation, (P less than 0.007). After IE, the control subjects "normalized" their ST-segment elevation, whereas it persisted elevated in the 5 Chagas' group I patients (P less than 0.003). These results suggest that in chagasic patients, the ST-segment changes observed during isometric exercise could be related to the presence of left ventricular apical aneurysm.

Adult↗

Expanding Medicaid coverage for pregnant women: estimates of the impact and cost.

An estimated 361,000 pregnant women are expected to be newly eligible for Medicaid coverage when all states raise the income ceiling for such coverage to 100 percent of the federal poverty level by 1990, as Congress has mandated. According to a methodology for projecting the effects of recent congressional changes in the Medicaid program, about 64 percent of these women would be otherwise uninsured, at least for maternity care, and the rest would have some insurance, so Medicaid would be the payer of last resort. Congress has also given states the option to cover pregnant women with incomes from 100 to 185 percent of poverty. If all states were to do so, another 552,000 women would become eligible, 29 percent of whom would otherwise have no insurance coverage for maternity care. The estimate of newly eligible women with incomes below 185 percent of poverty represents 24 percent of the 3.8 million women who give birth in the United States each year. Under the 100-percent-of-poverty ceiling, the estimated number of poor women eligible for coverage ranges from 4,000 or fewer in 18 states and the District of Columbia to 41,000 in California and Texas. At 185 percent of poverty, the number ranges from 4,000 or fewer in 11 states and the District of Columbia to more than 90,000 in California and Texas. Eight states have already elected to extend Medicaid coverage to the 185-percent-of-poverty ceiling.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Medicaid expenditures for maternity and newborn care in America.

An Alan Guttmacher Institute (AGI) survey of the Medicaid programs in each state and the District of Columbia found that some 542,000 low-income women have a Medicaid-subsidized delivery each year--about 15 percent of all women who give birth. The proportion ranges from three percent in Alaska to 25 percent in Michigan. The federal and state governments spend almost $1.2 billion annually for maternity care (including prenatal, postpartum and newborn care); the average expenditure per patient is $2,200. Tennessee reports the highest expenditure per patient ($3,500) and Louisiana the lowest ($1,300). Only the highest payments under Medicaid are close to charges for maternity care in the open market, a fact that results in a significant disincentive for physicians and hospitals to accept Medicaid patients. The $1.2 billion spent for Medicaid-subsidized maternity care compares with an estimated $11.5 billion spent for such care nationwide. Thus, Medicaid pays for about 10 percent of the nation's maternity care bill, although Medicaid subsidizes deliveries for 15 percent of all women who give birth. The figures for maternity care do not include Medicaid expenditures for neonatal intensive care, which, for the 17 states reporting data, average about $11,800 per infant. Although only about six percent of all newborns whose deliveries are subsidized by Medicaid require neonatal intensive care, such care is so expensive that it adds about 30 percent to all Medicaid expenditures for maternity care. Increased Medicaid payments for maternity care, including prenatal care, could have a positive impact on health outcomes for low-income mothers and their babies, and could reduce the necessity for massive and expensive medical treatment for newborns.

Child Health Services↗

Public benefits and costs of government funding for abortion.

In state referenda to end public funding of abortions for poor women, one of the most successful tactics of abortion foes has been to charge that abortion funding increases the burden on taxpayers. A state-by-state analysis by The Alan Guttmacher Institute (AGI) shows that the opposite is the case. For every tax dollar spent to pay for abortions for poor women, about four dollars is saved in public medical and welfare expenditures. The savings are in public expenditures that otherwise would have to be incurred because of the babies that poor women would have borne. On the basis of earlier research, it was assumed that 20 percent of Medicaid-eligible women who could not obtain abortions would give birth. Public costs examined in the AGI analysis include Medicaid expenditures for prenatal care, delivery and postnatal care for the mother, and for newborn care, neonatal intensive care and pediatric care for the child for the first two years of life; as well as expenditures for Aid to Families with Dependent Children (AFDC), food stamps and the Special Supplemental Food Program for Women, Infants and Children (WIC) during those first two years. The benefit-to-cost ratio varies from about 9:1 in Massachusetts to 2:1 in Hawaii and Pennsylvania. The net savings for the nation as a whole over a two-year period if abortions were publicly funded in every state would total at least $339.6 million.

Abortion, Legal↗