Search PubMed⌕ Search

Biomedical subjects

A Torres

Publications and source records attributed to A Torres.

At least 685 records · Page 38Linked to original sources
PubMed1983

Differences in GM-CSF production from mouse peripheral blood and spleen cells stimulated by different lectins.

The capacity of mouse peripheral blood and spleen mononuclear cells to produce GM-CSF or CSA, in response to the stimulation by different mitogens (PHA, PWM and ConA) was studied. Each different kind conditioned medium was tested on target bone marrow from BALB/C mice. A significant decrease in the number of CFU-GM, was observed using peripheral blood conditioned medium stimulated by PHA or ConA in comparison with spleen conditioned medium in response to identical mitogens. When PWM is used as source of GM-CSF, significant differences between spleen and blood conditioned media were not observed. The possible significance of these findings is discussed.

Animals↗
PubMed1982

[A new test-strip for checking blood-sugar levels].

Blood sugar levels in 228 EDTA-treated venous blood samples were measured in the laboratory by a new test-strip (Visidex) and the hexokinase reference method. There was good agreement between the two, with a linear correlation of r = 0.92 and a regression line with a slope of 0.98. 97.8% of all values deviated by less than one concentration range from the reference values. At low glucose concentrations the median of the absolute differences between the two methods was 9.5 mg/dl. Over the whole concentration range of 20-800 mg/dl the mean deviation from the reference values was between 14.4 and 32.6 mg/dl. The results indicate that the Visidex test-strip method is suitable for the visual estimation of blood sugar values.

Blood Glucose↗
PubMed1982

Functional activities and concentrations of plasmin inhibitors in normal subjects and D.I.C. patients.

Alpha-2-macroglobulin and fast antiplasmin, the main inhibitors of the fibrinolytic system, and the presence of plasmin-antiplasmin complex (P-AP) were studied in 15 DIC patients and in 20 healthy individuals. There was a lack of correlation between immunological and chromogenic substrates alpha-2 antiplasmin levels when P-AP complex were found in DIC patients (in 6/15 cases). The levels of alpha-2-macroglobulin were within the normal range in most of these patients, confirm the secondary role of this inhibitor in fibrinolysis.

Adolescent↗
PubMed1982

Dose-dependent inhibitory and non-inhibitory action of somatostatin on insulin release in rats.

The dose-dependent effect of intravenously infused synthetic somatostatin-14 on basal and postprandial insulin and gastrin release was assessed in anesthetized rats. Infusion of 1 ng . kg-1 . min-1 elicited a significant reduction of basal and postprandial insulin levels compared to the saline control groups. At 15 ng . kg-1 . min-1 basal insulin was not affected but postprandial insulin levels were still significantly reduced. At 30 ng . kg-1 . min-1 neither basal nor stimulated insulin levels were affected. At the highest concentration of 120 ng . kg-1 . min-1 basal and postprandial insulin levels were suppressed similar to lowest infusion rate of 1 ng . kg-1 . min-1. Basal gastrin levels were significantly reduced only at the highest rate of 120 ng . kg-1 . min-1. A significant reduction of postprandial gastrin levels was observed at 15 ng . kg-1 . min-1 and all higher infusion rates employed. Measurements of plasma somatostatin-like immunoreactivity (SLI) demonstrated that plasma SLI levels during the lowest infusion rate of 1 ng . kg-1 . min-1 were not different from the controls. No significant rise of plasma SLI levels was observed in response to the test meal. The higher infusion rates elicited a dose-dependent increase in plasma SLI levels. These data demonstrate that in rats somatostatin exerts a biological effects on insulin release at very low doses while certain greater infusion rates hae no suppressive effect. Gastrin secretion is inhibited in a more linear pattern.

Animals↗
PubMed1982

Effects of cimetidine on haematopoiesis in vitro.

The possible modifications in haematopoiesis induced by cimetidine were studied in normal bone marrow cultures in vitro. When cimetidine was added in the therapeutic range, there was no significant change in either granulocytic-macrophagic (CFU-GM) or erythroid (BFU-E) colony growth. However, when cimetidine was added to the culture at 2 to 25 times the therapeutic range, a small but significant inhibition of both types of colony growth was found. We conclude that cimetidine in the therapeutic range does not induce inhibition of haematopoiesis in vitro but does in doses above the therapeutic range when inhibition is dose-dependent.

Cimetidine↗
PubMed1982

A new method for the assessment of bone mass in renal osteodystrophy. Usefulness of computerized tomography in hemodialysis patients.

We have designed az method for the assessment of trabecular bone mass (TBM) in a central portion of L4 by means of CT scanning. A total of 29 normal individuals of different ages from both sexes, and 19 hemodialysis patients were studied. 3 selected patients were also studied 1 year later. A good in vivo reproducibility was demonstrated in a dog after repositioning. A positive inverse correlation was observed in the control group between age and TBM supporting the reliability of this method. As reported by others in the postmortem bone mineral analysis of L4, a majority of patients (78.9%) showed a normal or high TBM. From a total of 5 patients with increased TBM only 2 showed radiological osteosclerosis, and 4 of them presented advanced subperiostal resorption suggesting a pathogenetic role of excessive circulating PTH in the genesis of osteosclerosis. A total of 4 had decreased TBM and only 2 of them showed radiological demineralization, 2 patients with decreased TBM, 1 of them under anticonvulsant therapy, experienced a considerable increase in the TBM after 1 year of 25OHD3 therapy. We conclude that this method can be an important help in the early detection of management of renal osteodystrophy.

Adolescent↗
PubMed1982

[Changes in lymphoblastic transformation in preleukemic AKR/J mice].

The authors investigate the efficacy of the immune system along the AKR/J mouse life span. They employ the phytohemagglutinin (PHA)-induced lymphoblastic transformation test. The response is compared with the immune response obtained in BALB/C mice of the corresponding age. The blastic transformation was significatively lower at 15, 25 and 35 weeks in the AKR/J mouse than in the BALB/C mouse. At the age of 45 weeks the AKR/J mouse shows an increased proportion of lymphocytes in the thymus and spleen, a weight increase of these organs, and an augmented lymphoblastic transformation in response to PHA. This phenomena are not observed in the BALB/C mouse. When macrophages are removed from the lymphocytes preparation, the PHA-induced blastic transformation of lymphocytes is not produced at any age in either AKR/J or BALB/C mice strains.

Aging↗