Biomedical subjects

A Tomoda

Publications and source records attributed to A Tomoda.

111 records · Page 7Linked to original sources

PubMedDate not supplied

Circadian rhythm abnormalities in adrenoleukodystrophy and methyl B12 treatment.

A 13-year-old male with adrenoleukodystrophy (ALD) developed a sleep-wake disorder after complete vision loss. He had a 25-h sleep-wake cycle. After methyl B12 therapy, circadian rhythms in his plasma melatonin and beta-endorphin levels approximated those of healthy volunteers, and his peak cortisol time shifted backward. Daily deep body temperature (DBT) amplitude was smaller than in healthy males before and after the treatment, and his acrophase did not change. However, his sleep-wake rhythm became normal. Methyl B12 is considered useful for treating circadian rhythm disturbances in patients having central nervous system disorders and blindness.

Adolescent↗

PubMedDate not supplied

Correlates of problem drinking among young Japanese women: personality and early experiences.

Problem drinking patterns were measured by the CAGE questionnaire among 90 currently drinking young Japanese women who were recently recruited by a Japanese company. Problem drinking was examined in terms of personality (temperament and character as defined by Cloninger) and early life experiences (perceived parental behavior, parental abusive behavior, being bullied at school, and positive and negative life events experienced before the age of 16). Multiple regression analysis revealed that problem drinking could be predicted by a set of personality scores, early death of a close friend, and the interaction of the death of a close friend and low explorative excitability (novelty-seeking component 1). This suggests that problem drinking in young women is partly determined by both personality and negative life events during childhood.

Adult↗

PubMedDate not supplied

Variation of urinary pH and bicarbonate concentrations of students in metropolitan and rural areas of Japan.

Changes in urinary pH and bicarbonate levels were studied in urine collected before and after final examinations taken by 91 medical students (65 males, 26 females) in Tokyo and from 87 students (73 males, 14 females) in Kanazawa, a rural municipality. Bicarbonate levels and pH in the urine of students in both cities increased significantly after attending 2 h of final examinations. The highest pH value and highest bicarbonate level were 7.66 and 80.3 mM, respectively, found in the urine of a student in Kanazawa. Urinary pH and bicarbonate levels averaged 6.48 and 11.1 mM, respectively, for students in Tokyo and 6.26 and 8.91 mM, respectively, for students in Kanazawa. Given that the concentrations of carbon dioxide in the air of the classrooms in both cities increased drastically during the final examinations (i.e., from 700 ppm to 1 200 ppm in Tokyo and from 700 ppm to 1 500 ppm in Kanazawa), it appears that the increases in urinary pH and bicarbonate levels were correlated with the increase of carbon dioxide (known to be convertible to bicarbonate in blood) in the rooms. This was also supported by the increase in urinary pH and bicarbonate levels found in urine collected from 20 students who stayed in a cinema for 3 h, at which location carbon dioxide levels in air reached 1 200 ppm.

Adult↗