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Biomedical subjects

A Tilgner

Publications and source records attributed to A Tilgner.

27 records · Page 2Linked to original sources

[Histopathology of the arterial wall after animal experiment microsurgical operations].

Histologic findings on microvessels of laboratory animals are reviewed. Lesions of the microvascular wall may be caused by preparation, microvascular clips and anastomosis. The intensity of the closing pressure of microclips as well as the clipping time influence the extent of the damage. Thrombosis of microarteries was not seen, even after a clipping time of 2 hours. The vascular lesions were reparable. Four different techniques of anastomosis used experimentally and clinically were compared: end-to-end suture anastomosis (absorbable and non-absorbable sutures), telescopic 2-suture anastomosis, sutureless telescopic adhesive anastomosis (fibrinogen, IMMUNO AG Wien), and telescopic 2-suture adhesive anastomosis. The tissue restitution was better in suture anastomosis carried out with absorbable sutures than performed with non-absorbable suture material. The sutureless telescopic adhesive anastomosis is a very gentle method, but the anastomoses are not always stable enough. The advantages of the telescopic 2-suture adhesive anastomosis (absorbable sutures, fibrinogen adhesive) are relatively small lesions of the vascular wall, good restitution and sufficient stability. The patency rate (96%) corresponds to that of the end-to-end suture anastomoses (94%). The clinical application of the telescopic anastomosis is estimated critically, and evidently it is more suitable for microarteries than for microveins.

Animals↗

[Suture and gluing technics in microvascular surgery. Comparative animal-experiment clinical studies].

In 135 femoral vessels of rats (70 arteries, 60 veins) end-to-end anastomoses performed, using 3 different methods (anastomoses with interrupted sutures, two-suture telescopic anastomosis, sutureless telescopic anastomosis with fibrinogen adhesive). The advantages and disadvantages of these methods were investigated and valued by clinical aspects (time of anastomosing, patency rate, complications). The results showed that a combined two-suture-telescopic anastomosis using absorbable suture material and fibrinogen adhesive is very stable and causes minimal lesions of the vessel wall, so that this method will be a nearly ideal anastomosing technique.

Animals↗

Histopathologic findings in a human arterial anastomosis after free flap transfer.

During the removal of subcutaneous fat 4 months after free groin flap transfer in a 25-year-old male, the anastomosed artery was also removed for histologic examination. The removal of the artery did not impair flap viability. The considerable narrowing of the arterial lumen caused by extensive hyperplasia of the intima suggested a restriction of arterial function. In addition, the internal elastic membrane had disappeared or was partially intact, doubled, and fragmented. Where sutures were tight, necrosis of the media was found, with heavy scar formation. If the sutures were loose, the media remained intact. The tissue of the flap artery was more heavily altered than the tissue of the recipient artery. This was evidently the result of trauma incurred during preparation of the flap vessels. Functional restriction of the anastomosed artery and secondary flap revascularization apparently occurred in a temporally favorable relationship in this case.

Adult↗