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Biomedical subjects

A Tiilikainen

Publications and source records attributed to A Tiilikainen.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Increase of HLA haplotype A9-Bw16 in familial insulin-dependent diabetes mellitus in northern-Finland.

Twenty-one families, each with two diabetic children, from North Finland were HLA typed. The grade of HLA identity between diabetic siblings was evaluated, and frequencies of various HLA antigens in familial cases were compared to those of non-familial cases from the same area. Ten pairs of diabetic children were HLA-identical and eleven haploidentical; two of the latter were identical for the HLA-D locus. These figures emphasize the significance of HLA-region associated genetic factors in the susceptibility to the disease, but do not support a simple dominant/recessive gene theory. There was a significant difference between familial and non-familial IDDM cases in the frequencies of B15, Bw16, B40 and Cw3 antigens. Bw16 was greatly increased and B15, B40 and Cw3 decreased among familial cases. The haplotype A9, Bw16 was common in familial cases, but, compared to healthy controls, the frequencies of the two antigens were also slightly increased among non-familial cases. Neither Dw3 nor Dw4 was associated with Bw16 antigen. The differences between familial and non-familial IDDM cases and the significance of the A9, Bw16 combination in the patients emphasize the heterogeneity of IDDM.

Diabetes Mellitus↗
PubMedDate not supplied

Results in necrokidney transplantation to pair recipients.

Attempting to find out whether universal kidney donors exist in the same sense as do universal blood donors this investigation was performed on donors and recipients in 45 pair transplantations, or in other words on 90 recipients transplanted with kidneys from 45 donors (G.S. 6 months). The result of pair transplantation was the same in the two recipients in 23 instances; 15 pairs had successful transplantations while the grafts failed in 8 pairs. In 22 pair transplantations the two recipients had different postoperative records. The mean age of the donors was 32 years, the mean age of the recipients 42. The donor age was lower in the successful pair transplantations than in the failures. The duration of cold ischaemia ranged from 6.6 to 9 hours in the different groups. The results of transplantation were not influenced by the duration of ischaemia. A higher degree of histocompatibility and a greater number of shared haplotypes were features typical of the successful cases. Moreover, antibodies occurred less frequently in connection with successful transplantations. Absence of shared halotypes and/or incompatibility in locus B had an unfavourable effect on the course of grafting. By contrast, the presence of blood group O in both donor and recipient and even in donor alone had a favourable effect. HLA-A2 occurred less frequently and A1 and B8 more frequently in donors whose grafts failed than in the donors of successful pair transplants. The question of whether a universal kidney donor exists could not be definitely answered on the basis of this investigation.

Adult↗