Biomedical subjects

A Tenhunen

Publications and source records attributed to A Tenhunen.

27 records · Page 2Linked to original sources

PubMed1984

Peritoneal fluid 6-keto-prostaglandin F1 alpha, thromboxane B2 in endometriosis and unexplained infertility.

To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGF1 alpha (a breakdown product of prostacyclin) and thromboxane B2 (T X B2) (a metabolite of T X A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endometriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGF1 alpha and T X B2 in PF were increased (p less than 0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGF1 alpha and T X B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1 alpha/T X B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T X A2 may be involved in infertility by interfering with tubal function.

6-Ketoprostaglandin F1 alpha↗

PubMed1984

Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility.

To elucidate the roles of prostaglandins in peritoneal fluid and sex steroids in patients with endometriosis (N = 29), tubal disorders (N = 15), and unexplained infertility (N = 13), assays were performed using 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) (a metabolite of prostacyclin), thromboxane B2 (a metabolite of thromboxane A2), estradiol, and progesterone. Women with normal pelvic anatomy (N = 25) served as controls. Peritoneal fluid 6-keto-PGF1 alpha concentrations in patients with endometriosis (742 +/- 104 pg/ml, mean +/- SE), tubal disorders (987 +/- 211 pg/ml), and unexplained infertility (1659 +/- 770 pg/ml) were higher than those in the control women (515 +/- 77 pg/ml). The thromboxane B2 levels in the peritoneal fluid in endometriosis (554 +/- 73 pg/ml), tubal disorders (614 +/- 107 pg/ml), and unexplained infertility (668 +/- 161 pg/ml) were higher than the levels in the control subjects (333 +/- 23 pg/ml). There was no relationship between 6-keto-PGF1 alpha/thromboxane B2 in peritoneal fluid and day of menstrual cycle. The concentrations of estradiol and progesterone were normal in all patient groups and were not related to the 6-keto-PGF1 alpha and thromboxane B2 levels. The authors suggest that these prostanoids, which may contribute to infertility, may originate mainly from the peritoneum as a result of irritation by endometriotic implants, tubal adhesions, and scarring.

Adult↗

PubMed1984

Hyperstimulated human preovulatory follicular fluid contains placental protein 5 (PP5).

Placental protein 5 (PP5)-like immunoreactivity was found in 22 of 28 fluids aspirated from hyperstimulated preovulatory follicles of women who participated in an in vitro fertilization program. When detectable, the PP5 levels varied from 7 to 67 micrograms/l, which are of the same order of magnitude as those seen in pregnancy sera. In gel filtration, the PP5-like immunoreactivity of follicular fluid eluted in the same volume as purified human placental PP5; and in radioimmunoassay, this substance gave an inhibition curve which was parallel to that of the PP5 standard. A positive correlation was observed between the follicular fluid concentration of estradiol and PP5 (r = 0.60; P less than 0.001), but not between the levels of progesterone, testosterone, or follicular volume and the PP5 concentration. In light of the protease inhibitor nature of PP5, its detection in preovulatory follicular fluid is intriguing in relation to its possible role in the rupture of the follicle.

Chorionic Gonadotropin↗

PubMed1980

Management of vaginal agenesis.

Long-term results obtained through different methods of treatment were analysed in a series of 39 patients with congenital absence of the vagina. Thirty-three patients were treated with the McIndoe skin graft technique, 6 of them by the modification of Counseller and Davis. In three patients the neovagina was grafted with amnion and three were treated with the Frank nonoperative method. The result was graded good in 27 and satisfactory in 11 patients. In one patient the McIndoe operation resulted in a complete failure. There was no obvious difference between the results obtained by different methods except for the modification of Counseller and Davis which gave a good result in all cases. Judging from the general appearance and cytological pattern of the artificial vagina a more physiological result was achieved in patients with an amnion graft as compared with those with a skin graft. The nonoperative method is suggested as the first alternative in the treatment of patients with congenital absence of the vagina.

Adolescent↗

PubMed1973