[Anorectal malformations. Classification].
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Anal Canal↗
Biomedical subjects
A Teixeira
Publications and source records attributed to A Teixeira.
[The seroprevalence for hepatitis E viral antibodies in the northern region of Portugal (among the donor population)].
The authors have undertaken a study in the north of Portugal in what concerns the prevalence of antibodies for HEV donors. This study was transverse through observation and survey. A sample of 1.473 donors was randomly selected from among the population of donors of the Oporto Regional Blood Centre. This sample was representative of the northern region and stratified by district. The usual EIA method has been used to search for HEV antibodies. The results, which were repeatedly reactive, have been confirmed by Western Blot. The prevalence of antibodies for Hepatitis E was 2.5%. The test identified a possible cohort effect and the sample showed that the average age of the donors with or without antibodies was identical. No difference was observed regarding sex, distribution by districts or the presence of antibodies for HB virus. Hepatitis E is benign, without chronic state carrier and almost every patient presents acute symptomatology. The value of prevalence found as well as the absence of clinical symptomatology in the observed donors and the normal state of the hepatic markers, indicate that the use of blood and components obtained from this population should not be a problem. The recommendation proposed by the European Council does not mention the systematic research of HEV. However the epidemiological HEV survey is considered important from the transfusional point of view and as an indicator of the sanitary development of the population. Bearing in mind the developing status of Portugal in this area, it is of utmost importance to create the means to reach European standards.
Adult↗
[Diastolic dysfunction in patients with chronic kidney failure on a hemodialysis program].
OBJECTIVE: The aim of this study was to analyse different ultrasound parameters for the assessment of isolated left ventricular diastolic dysfunction (LVDD) in patients with chronic renal failure (CRF) on periodic hemodialysis (HD), comparing pulsed wave Doppler with pulsed tissue Doppler. MATERIALS AND METHODS: Forty-seven patients with CRF on HD (61% were male; mean age was 51.0 +/- 16.5 years, mean HD time--3.7 +/- 3.8 years, 38% had hypertension, 17% had diabetes) were studied by echocardiography (bidimensional, M-Mode, flow pulsed Doppler and tissue Doppler imaging). All patients had symptoms of left heart failure-class II NYHA, were in sinus rhythm and had no symptoms of ischemic heart disease. The presence of abnormal LV regional contractility was the exclusion criteria. According to their mitral inflow profile Doppler characteristics, patients were included in two groups: Group A (E/A > 1; n = 21) and B (E/A < 1; n = 26). We compared: LV dimensions and function, left atrial (LA) dimension. Gaasch index, LV mass index. E and A wave velocities (in flow pulsatile Doppler and tissue Doppler). E/N ratio in tissue Doppler, isovolumetric relaxation time (IVRT) and deceleration time (DT). RESULTS: There were no significant differences in the prevalence of age > or = 65 years male sex, hypertension or diabetes between group A and B patients, and almost all patients were on hemodialytic treatment for more than one year (81% vs 85%: NS). LV hypertrophy was present in almost all group A and B patients (A--95% vs B--85.5%; NS). Group A, compared with group B, had a difference in the Gaasch index (2.45 +/- 0.3 vs 2.08 +/- 0.4; p < 0.05), E wave velocity in flow pulsatile Doppler and tissue Doppler (cm/sec) (110 +/- 27 vs 62 +/- 20; p < 0.001 and 41 +/- 15 vs 28.5 +/- 16; p < 0.05), E/A ratio in tissue Doppler (1.3 +/- 0.4 vs 0.8 +/- 0.3; p < 0.001). IVRT (msec) (80.7 +/- 15.2 vs 113.5 +/- 28.3; p < 0.001) and DT (msec) (189.7 +/- 24 vs 278.2 +/- 17.9; p < 0.001). According to the E'/A' ratio in tissue Doppler, group A patients were divided in another two groups: E'/A' > 1 (13/21--62%) and < 1 (8/21--38%) and a significantly longer IVRT (75.8 +/- 9.3 vs 100.9 +/- 3.2; p < 0.001) and DT (178 +/- 15 vs 240 +/- 20; p < 0.001) and a greater LA dimension (37.6 +/- 6.9 vs 44.6 +/- 6.9; p < 0.05) were found. CONCLUSIONS: Pulsed wave Doppler is the most useful non invasive method for assessment of global diastolic dysfunction. In our study, 17% of the patients had E/A < 1 only in the tissue Doppler study. These patients probably had a pseudonormal mitral pattern.
Adult↗