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A Tateishi

Publications and source records attributed to A Tateishi.

At least 91 records · Page 5Linked to original sources

[Clinicopathological study of twenty-two cases of benign chondroblastoma (author's transl)].

Benign chondroblastoma, a rare bone tumor clinically and histologically resembles giant cell tumor. We have experienced twenty-two cases of histologically confirmed benign chondroblastoma over the 25 year period from 1952 to 1978. The age of the patients ranged from 10 to 46 years, with an average of 20 years. Fifteen cases were in the second decade. Males were predominant to females with a ratio of 2.7:1. Location of the tumor varied widely. The tumor was located in the long bones in 18 out of 22 and limited to the epiphysis in 15. Detailed histological examination in twelve cases with hematoxylin-eosin, alucian blue, toluidine blue, silver impregnation and safranin-O staining, revealed positive staining with alucian blue and PAS. PAS positive granules wee found within cytoplasm and identified as glycogen granules by electron microscopy. However, metachromasia was not always positive and none of these cases stained positive with safranin-O. Rich reticulin fibers encircled each tumor cell and each group of cells. Electronmicroscopic study of 4 cases revealed two types of giant cells. The cell membrane had many microvilli-like protrusions, and the nuclei of the tumor cells were irregular in appearance and had large indentations. Sometimes many fine filaments and electron dense fine granules were observed in intercellular chondroid space. Morphological study of cultured cells was done in two cases. Morphology of these tumor cells proved to be different from fibroblasts, cultured chondrocytes and macrophages. Tumor cells moved rapidly and had undulating membranes at the pseudopodia. From these findings, we speculated that the origin of the benign chondroblastoma cell may be histiocytic cells. Surgical treatment of this tumor was carried out as follows. Curettage was performed in 16 cases, with bone graft in 15, resection 4 and amputation in two. Recurrence was noted on two cases, although no further recurrence occurred after reoperations for nine and twelve years respectively.

Adolescent↗

Clinical features of 22 cases with "inter-sterno-costo-clavicular ossification". A new rheumatic syndrome.

We present 22 cases with inter-sterno-costoclavicular ossification. Clinical and pathological findings show that abnormal ossification observed in this situation is due to non-suppurative chronic inflammation of the soft tissues around the sterno-costo-clavicular region such as the costo-clavicular ligament. We have classified X-ray findings into three stages according to the extent of the ossification; localized, generalized, and hyperostotic, and show that the disease progressed in this sequence. A considerable number of the patients showed abnormal X-ray findings in the spine or the sacro-iliac joint. Frequent association of pustulosis palmaris et plantaris was noted in this disease. Most of the cases were treated effectively with anti-inflammatory drugs, but a few cases required surgical resection of the ossified mass with the clavicle or the first rib in order to relieve the severe pain.

Adult↗

Typical and atypical osteosarcomas: a clinicopathologic study of sixty-two cases.

Of 62 cases of histologically confirmed osteosarcomas, 50 long bone cases aged under 30 years were grouped as "typical" osteosarcoma, and the other 4 long bone cases and 8 short and flat bone cases were grouped as "atypical" osteosarcoma. Gross and microscopic findings of the lesions, postmortem findings, and survival of the patients were compared between the two groups. Small round cell-type tumor cells and relatively well-differentiated foci resembling osteoblastoma were more often found in the atypical than in the typical osteosarcomas. Although patterns of metastasis were not very different between the two groups, 2 of 6 autopsied short and flat bone cases showed no metastasis. Five-year survival rates of both groups were similar, each about 25%. Six patients of the typical and only one of the atypical osteosarcomas are alive without recurrence more than 6 years after amputation.

Adolescent↗

Membranous lipodystrophy: a clinicopathological study of six cases.

Membranous lipodystrophy apparently is a new disease, first reported and named by Nasu and associates 31 in 1971. We have collected six cases of this disease. The initial manifestation was articular pain at adolescence. Symmetrical changes in the bones of the extremities then appeared and the disease seemed to progress slowly with age. The younger patients exhibited only skeletal pain or fractures, while the older patients had some neuropsychiatric changes. Three of the patients died in middle age. The cystic bone lesions contained a yellow, lipid-like substance which histologically showed a characteristic membranocystic appearance. Electron microscopic study showed unique features, but biochemical analysis of the substance did not reveal a definable abnormality.

Adult↗

Osteogenic sarcoma. A study of one hundred and thirty cases.

One hundred and thirty patients with osteogenic sarcoma were studied clinically, roentgenographically, and pathologically. Prognosis by each of ten factors was analyzed with the Wilcoxon test. The test yielded p smaller than 0.05 in a comparison between the survival curves of patients fifteen years old or younger and that of patients over fifteen, but other comparisons did not yield p smaller than 0.05. The actual five-year survival rate was 25.5 per cent (twenty-six of 102 patients who had radical surgery). Our therapeutic regimen for osteogenic sarcoma at the present time consists of regional perfusion, amputation, bronchial artery infusion, and systemic administration of anticancer agents.

Adolescent↗