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Biomedical subjects

A Tanew

Publications and source records attributed to A Tanew.

46 records · Page 3Linked to original sources
PubMed1988

[Cholesterol embolization following anticoagulant treatment].

A 65-year-old female patient with pulmonary embolism developed widespread, extremely painful hemorrhagic necroses of the skin and subcutaneous tissue of the lower extremities 5 weeks after initiation of anticoagulation therapy. Due to the clinical and histopathologic findings and the course of the disease, a diagnosis of cholesterol embolization was made. The characteristic features of this clinical entity and differential diagnostic considerations are discussed.

Aged↗
PubMed1987

UV-induced unscheduled DNA synthesis in human skin: dose response, correlation with erythema, time course and split dose exposure in vivo.

Unscheduled DNA synthesis (UDS) has been shown to be saturated above a threshold dose of UV-C in human fibroblasts in vitro. We have investigated by autoradiography whether a similar saturation occurs in human skin in vivo with UV-B and whether this phenomenon correlates with the erythemal response. In addition, we determined the time course of UDS at 24 h after exposure and the effect of dual exposures separated by 24 h. The dose-response curve was established by exposure to 1/16, 1/8, 1/4, 1/2, 1, 2, 3, 4 and 6 MEDs UV-B. For the time-course study, areas exposed to 1/2 and 2 MEDs were biopsied after 1, 3, 6, 12 and 24 h. Autoradiography was performed in vitro. The dose-response curve showed a significant increase in UDS from 1/16 to 1 minimal erythema dose (MED), whereas no significant difference was observed between 1 MED and the higher UV-B doses tested. The 24 h time sequence revealed a gradual decrease in UDS activity. The 1/2 MED curve declined more rapidly and reached the zero-level between 12 h and 24 h, whereas about 50% of the initial UDS value was still retained 24 h after 2 MEDs. The dual-dose study revealed that a second hit of fractions of the MED resulted in lower levels of UDS than induced by these fractions alone in previously untreated areas. UDS increases with the erythemal dose between 1/16 and 1 MED. It reaches a plateau after 1 MED and cannot be increased by doses up to 6 MEDs, suggesting a saturation of excision repair in vivo. Time course studies support such a saturation phenomenon. The failure to increase significantly UDS by a second irradiation 24 h after the first exposure needs further clarification. Since persistence of DNA lesions may lead to an accumulation after repeated exposures, additional mechanisms other than excision repair may protect human skin by error-free removal of possibly mutagenic sites. Photoreactivation may be important in this respect.

Adult↗
PubMed1986

Polymorphous light eruption: action spectrum and photoprotection.

Polymorphous light eruption is a common seasonal photodermatosis with a typical history and clinical picture. In the interval, when no lesions are present, the diagnosis relies on artificial reproduction of polymorphous light eruption by phototesting. Photochemotherapy (psoralens with ultraviolet A [PUVA]) is currently an effective preventive treatment. One hundred sixty-seven patients with either a history of polymorphous light eruption or manifest disease entered our study. Of 142 patients tested, 49% developed typical lesions of polymorphous light eruption at the test sites. In 56% the action spectrum was found to be in the ultraviolet A range, in 17% in the ultraviolet B range, and in 26% in both ranges. A total of 122 patients received preventive treatment with PUVA. Of these, fifty-one returned for follow-up. Of the patients who were followed up, 64% reported total protection during outdoor activities in the summer, 26% reported partial protection, and 10% were not protected. Failure to improve was unrelated to the action spectrum. The action spectrum and the incidence of positive results on phototests in our patient population differed from those reported by others. It is possible that differences in the test protocols and in the light sources used may account for this discrepancy. There is clearly a need for a standardized test procedure. However, the majority of patients benefit from PUVA pretreatment regardless of their action spectrum.

Adolescent↗
PubMed1986

Nonmelanoma skin tumors in long-term photochemotherapy treatment of psoriasis. An 8-year follow-up study.

Two hundred ninety-seven long-term photochemotherapy (PUVA)-treated patients from an original cohort of 418 subjects reported in 1980 were reevaluated in a second follow-up in order to determine the risk of tumor development under long-term PUVA. Within an observation period of up to 8 years (mean, 63.1 months) six patients with squamous cell carcinomas and three with basal cell carcinomas were observed. Eight of the nine tumor patients had been exposed to potential carcinogens such as arsenic and/or ionizing radiation prior to PUVA treatment. Five with squamous cell carcinomas were skin type I or II; in four of the six patients with squamous cell carcinomas the tumors were located on unexposed skin areas. The mean cumulative ultraviolet A (UVA) dose in three of the six squamous cell carcinoma patients was three times as high as that in the group of nontumor patients. The other three squamous cell carcinoma patients had lower mean doses than nontumor patients, as did the three patients with basal cell carcinomas. Although the cumulative UVA dose may eventually turn out to be relevant for PUVA carcinogenesis, our present data do not sufficiently substantiate a correlation between cumulative UVA dose and squamous cell carcinoma formation in PUVA-treated patients. This report confirms that previous exposure to carcinogens appears to be the most important factor for nonmelanoma skin tumor formation in long-term PUVA patients.

Adult↗
PubMed1986

Vitiligo treatment.

Explore the source record for details and available documents.

Alanine Transaminase↗
PubMed1985

[Blood group isoagglutinins and immunoglobulins (IgG, IgM) in old age].

Titres of blood-group isoagglutinins and the serum concentration of immunoglobulins M and G were investigated in 388 inmates (89.7% females) of an old-age home, ranging in age from 78 to 99 years [mean (+/- s) = 85.7 years +/- 4.1 years]. Concentrations of isoagglutinins were positively correlated to the concentrations of IgM (total concentration of IgM corr. to IgM anti-B (group A): p less than 0.0005, corr. to IgM anti-A (group B): p less than 0.01, corr. to IgM anti-B (group 0): p less than 0.025), but not to the concentration of IgG. The blood group A IgG red cell alloantibodies (IgG anti-B) indicated, in the low titre range, a positive correlation (p = 0.025) to the IgM isohaemagglutinins (IgM anti-B); the red cell alloantibodies (IgG, IgM) of the other blood groups did not correlate in this way. There was no age-dependent reduction or increase in isohaemagglutinin titres and/or total immunoglobulin levels. From these date we conclude that the lack of red cell alloantibodies in the serum of elderly patients in case of routine ABO blood grouping should not be accepted any more. There has to be an internal diagnosis available or, if missing, coinciding diagnostic tests should be performed.

ABO Blood-Group System↗
PubMed1984

[Direct Coombs' test in the aged].

Blood samples from 431 persons (age: 78 to 99 years) were examined by the direct anti-human-globulin test (d. AHGT ) with polyspecific and monospecific antisera. Three antibody-mediated positive d. AHGT were found. There was no increase in non antibody-mediated positive complement Coombs reactions in healthy persons of high age.

Aged↗
PubMed1977

[Concentration of protein-bound iodine in the serum of women in puerperium in the 1st 10 days post partum].

Serum protein-bound iodine was investigated according to the requirements of the method at Barker and coll. in 127 women without clinical signs of thyroid disorders during the first 10 days after births. Immediately, after parturition the level of serum protein-bound iodine was elevated, while it decreased during the first 10 days of puerperium, reaching normal values about the 10th day after birth.

Blood Proteins↗