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Biomedical subjects

A Takeuchi

Publications and source records attributed to A Takeuchi.

At least 271 records · Page 15Linked to original sources
PubMed1990

[Free arterial graft in coronary artery bypass surgery].

Free arterial graft of the internal mammary artery (IMA) and the gastroepiploic artery (GEA) has been utilized for coronary artery bypass grafting in 10 patients during 44 months period. There were 6 males and 4 females and age ranged 42 to 73 year old with the mean of 60.8 year old. Eight IMA and 2 GEA were used as a free graft. Sites of distal anastomosis of the free graft were 3 at anterior descending arteries, 3 at diagonal branches and 4 at circumflex arteries. Sites of proximal anastomosis of those grafts were ascending aorta in one, concomitantly utilized saphenous vein graft in 5 and in situ IMA graft in 4 patients. Mean number of grafts was 2.9 (2-5) and mean aortic cross clamp time was 56.2 minutes (16-90 minutes). There was neither operative death, nor perioperative myocardial infarction and intra-aortic balloon pumping was not required. Postoperative angiography was made in 9 patients within 3 postoperative months. Eight (89%) free arterial grafts were patent. Relief of angina was obtained in all patients. We concluded that the complete revascularization with only arterial graft can be achieved more widely by utilizing the free arterial graft with an acceptable patency.

Adult↗
PubMed1990

[Results of sequential aorto-coronary bypass grafting using saphenous vein graft].

Seventy patients underwent sequential coronary artery bypass grafting with saphenous vein during 28 months period. Seventy eight sequential grafts comprising 165 distal anastomoses were performed. Early death was 2.9%. Postoperative angiographic evaluation within 6 months showed 86% patency of the 65 sequential grafts and 89% patency of the 136 distal anastomoses. The patency of anastomosis to left anterior descending artery (LAD), diagonal branch (Dx), obtuse marginal branch (OM), posterior lateral branch (PL), and posterior descending branch (PD) was 87% (13/15), 92% (36/39), 91% (40/44), 81% (26/32) and 100% (6/6), respectively. The patency of Dx-LAD, Dx-OM and OM-PL was 86% (12/14), 94% (15/16) and 76% (13/17), respectively. There was no significant difference in the patency rate according to the site of anastomosis and the inner diameter of the coronary artery. The patency of side to side anastomoses was 92% (65/71) which was not significantly different from that of the end to side anastomoses; 86% (56/65). These results showed sequential aorto-coronary vein grafting means to be effective for the complete coronary artery revascularization .

Aged↗
PubMed1989

Regulatory activities of 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3, a novel synthetic vitamin D3 derivative, on calcium metabolism.

Regulatory activities of 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3 [ED-71], a novel synthetic vitamin D3 derivative, on calcium metabolism were investigated. The compound behaved similar to 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3] in the ex vivo intestinal calcium transport using rat everted gut sac and the in vivo bone mobilization using vitamin D-deficient rats. By means of Raisz's assay method, 45Ca releasing activity of ED-71 was not greater than that of 1,25(OH)2D3. The time course curve of ED-71 in plasma made a mild round shape compared with that of 1,25(OH)2D3 and the former's plasma concentration remained increased longer than the latter's. The therapeutic effect of ED-71 for the animal models with osteoporosis seemed to be better than that of 1,25(OH)2D3. The results suggest that ED-71 may be a promising drug for therapy of osteoporosis.

Animals↗
PubMed1989

Mononeuritis multiplex in incomplete Behçet's disease: a case report and the review of the literature.

A case of Behçet's disease with peripheral nervous system involvement is described. A 58-year-old female with a 16-year history of Behçet's disease was admitted to our hospital because of numbness in multiple areas in both the upper and lower extremities. A biopsy of the sural nerve revealed degeneration of the axons and a capillary lesion. This finding was compatible with mononeuritis multiplex. This case of Behçet's disease with biopsy-proved mononeuritis multiplex is a very rare one.

Behcet Syndrome↗
PubMed1989

Myocardial revascularization with combined arterial grafts utilizing the internal mammary and the gastroepiploic arteries.

Coronary artery bypass grafting with a combined arterial graft using both the internal mammary artery and the right gastroepiploic artery was performed in 22 patients during a 21-month period. There were 17 men and 5 women ranging in age from 34 to 73 years (mean age, 53.4 years). Three patients were having a reoperation, and 2 patients had no segment of long saphenous vein available. Twelve patients were less than 55 years old. The mean number of distal anastomoses including vein grafts was 3.2 and the mean number of arterial grafts was 2.5 per patient. The mean aortic cross-clamp time was 63.8 minutes and the mean cardiopulmonary bypass time was 116.7 minutes. There was 1 early and 1 late death. The other 20 patients are alive without angina. Studied within 3 postoperative months, graft patency was 95% (19/20) in internal mammary artery and 93% (14/15) in gastroepiploic artery grafts. It is concluded that the combined arterial graft can be used safely and effectively, and its application facilitates complete revascularization with more arterial and fewer vein grafts.

Adult↗
PubMed1989

Combined coronary revascularization and splenectomy.

Idiopathic thrombocytopenic purpura is rarely associated with coronary artery disease. In this report, we describe the successful surgical management of a patient with idiopathic thrombocytopenic purpura and angina pectoris.

Adult↗
PubMed1989

Combined revascularization of coronary and femoral arteries: a proposed alternative.

Two patients with both coronary artery disease and leg ischemia were successfully treated with a combined revascularization procedure. Coronary arteries were bypassed with in situ internal mammary artery grafts, and bilateral femoral arteries were bypassed with expanded polytetrafluoroethylene grafts descended from the ascending aorta through the preperitoneal abdominal wall tunnel. Both patients recovered well and experienced no angina or claudication.

Aged↗
PubMed1989

Effects of ergocalciferol supplementation on the concentration of vitamin D and its metabolites in human milk.

The effect of maternal ergocalciferol (vitamin D2) supplementation on the concentrations of vitamin D, 25-hydroxyvitamin D (25-OH-D), 24R,25-dihydroxyvitamin D [24,25-(OH)2D], and 1 alpha,25-dihydroxyvitamin D [1,25-(OH)2D] in their milk was studied. Vitamin D2, D3, 25-OH-D2 and 25-OH-D3 were simultaneously determined by high performance liquid chromatography, and the determination of 24,25-(OH)2D and 1,25-(OH)2D was performed by competitive protein binding assay and radioreceptor assay, respectively, after separation of the D2 and D3 compounds. After healthy lactating mothers had received a daily oral dose of vitamin D2 (1,200 IU/d) for 4 wk, the concentrations of vitamin D2, D3 and the metabolites were determined in their plasma and milk. Although the plasma levels of 25-OH-D2 were significantly increased, the increase in milk was relatively small. On the other hand, the increase of vitamin D2 levels in milk was greater than that of 25-OH-D2 in milk after supplementation. The levels of 1,25-(OH)2D in milk was lower after 5 wk of lactation than after 1 wk of lactation, regardless of maternal vitamin D2 supplementation. When total antirachitic activities in milk were calculated, only a very slight increase was observed as a result of supplementation.

24,25-Dihydroxyvitamin D 3↗
PubMed1989

Magnetocardiographic studies of ventricular repolarization in old inferior myocardial infarction.

Isomagnetic maps of 50 normal subjects (control group) and 23 patients with old inferior myocardial infarction (IMI group) were recorded in order to analyse T wave abnormalities in inferior myocardial infarction. The T wave of the magnetocardiogram (MCG) in the control group showed negative deflections in the left upper portion and positive deflections in the right lower portion, thus resulting in a T vector directed leftward and inferiorly. The T wave of the IMI group was flat or positive in the left upper portion and flat or negative in the right lower portion, suggesting a T vector directed superiorly. In addition, opposing dipoles were observed in 36.4% of the IMI group; i.e. one directed superiorly, presumably due to inferior myocardial ischaemia, and the other directed inferiorly due to normal repolarization. Localized T vector abnormalities could be detected by the MCG in some cases, in which coronary T waves of the standard electrocardiogram had returned to normal. Furthermore, multiple dipoles were more frequently observed in the isomagnetic map than in the isopotential map (5 vs. 15; P less than 0.01). These results suggest that the MCG is helpful in diagnosing myocardial ischaemia when this is not detectable on the electrocardiogram.

Adult↗
PubMed1989

Studies of a glomerular permeability factor in patients with minimal-change nephrotic syndrome.

Peripheral blood mononuclear cells (PBMC) from patients with minimal-change nephrotic syndrome (MCNS) were tested for their ability to produce a factor which increases the urinary protein excretion levels of rats. It was shown that enhanced proteinuria can be produced in 8-hour urine specimens from rats by the injection of concentrated supernatants of cultured concanavalin-A-stimulated PBMC of patients with MCNS, but not from other nephrotics or normal subjects. The increase in urinary protein excretion was associated with a significant alteration of glomerular epithelial cells similar to that seen in MCNS. These results suggest that in MCNS, PBMC release a factor, which we termed a glomerular permeability factor (GPF), causing changes in glomerular permeability with resulting proteinuria.

Adolescent↗
PubMed1989

A case of successful coronary artery bypass grafting in a patient with angina pectoris and hypothyroidism.

There is a clinical dilemma in the treatment of patients with hypothyroidism and coronary artery disease; excess thyroid hormone administration may exacerbate anginal symptoms, and yet inadequate thyroid replacement may induce congestive heart failure. A case of successful coronary artery bypass grafting in a patient with angina pectoris and hypothyroidism is described in this paper. A 55 year-old woman with this complication initially received thyroid replacement therapy under strict monitoring. Forty days after the start of the thyroid replacement therapy, serum levels of thyroid hormone had reached the normal range, and then coronary artery bypass grafting was successfully performed. She recovered without any complications, and is now free from chest pain in spite of thyroid replacement therapy.

Angina Pectoris↗
PubMed1989

Results of multiple coronary artery bypass grafting in Japanese patients.

Multiple coronary artery bypass grafting with more than 4 grafts has been carried out in 64 Japanese patients during a 3.5 year period. There were 55 males and 9 females; ages ranged from 34 to 75 with a mean of 58.9 years old. Double, triple and left main disease were noted in one (2%), 54 (84%) and 9 (14%) patients, respectively. There was 54 (84%) stable and 10 (16%) unstable angina pectoris, and 28 (44%) patients had previous myocardial infarction. The saphenous vein graft was used for all patients with a preferential use of sequential graft (84%). The internal mammary artery graft was used in 55 (86%) patients and the right gastroepiploic artery graft was used in 6 (9%) patients. There were 2 (3.1%) early and 2 (3.1%) late deaths. New Q wave was noted in 2 (3.1%) patients and intraaortic balloon pumping was required in 3 (4.7%) patients. The mean number of grafts was 4.4 ranged from 4 to 7, and the mean aortic cross clamp time and cardiopulmonary bypass time was 74.5 min and 134.3 min, respectively. Graft patency within 6 postoperative months was 86% (120/140) in saphenous veins, 96% (52/54) in internal mammary arteries and 100% (5/5) in gastroepiploic arteries. Relief of angina was noted in 58 (96.7%) of 60 survivors. It was concluded that the increase in the number of coronary artery anastomoses does not increase surgical risk and favorable outcome and acceptable graft patency can be obtained by multiple grafting for patients with severe multivessel coronary artery disease.

Adult↗
PubMed1989

Protein-binding properties of 22-oxa-1 alpha,25-dihydroxyvitamin D3, a synthetic analogue of 1 alpha,25-dihydroxyvitamin D3.

Protein binding properties of 22-oxa-1 alpha,25-dihydroxyvitamin D3 (22-oxa-1,25-D3), a synthetic analogue of 1 alpha,25-dihydroxyvitamin D3 (1,25-D3), were compared with those of vitamin D3 derivatives. The order of binding affinity to the chick embryonic intestinal receptor was 1,25-D3 greater than 22-oxa-1,25-D3 greater than 25-hydroxyvitamin D3 (25-D3) greater than 24R, 25-dihydroxyvitamin D3 (24, 25-D3) greater than vitamin D3 (D3), while that to the rat plasma vitamin D-binding protein (DBP) was 25-D3 greater than 24,25-D3 greater than D3 greater than 1,25-D3 greater than 22-oxa-1,25-D3. The binding potencies of 22-oxa-1,25-D3 to the receptor and DBP were about 1/8 and 1/600 of the respective values of 1,25-D3. When the distribution of the tritiated compounds in human plasma components was examined by an in vitro polyacrylamide gel electrophoretic method, [3H]-22-oxa-1,25-D3 was found to bind only to the lipoproteins including chyromicron. These results suggest that the replacement of a carbon atom into an oxygen atom in the side chain structure of 1,25-D3 results significant decrease in the binding affinity to DBP and that 22-oxa-1,25-D3 is transported as a complex-form not with DBP but with lipoprotein to the target tissues.

Animals↗
PubMed1989

[Diffuse narrowing of the internal mammary artery graft--the thinning phenomenon].

Diffuse narrowing of the internal mammary artery graft (IMAG), the thinning phenomenon, was found in 8 (6.7%) out of 120 IMAGs underwent postoperative angiography. There were 6 males and 2 females, and mean age was 55.3 ranged from 37 to 70 year-old. There was no significant correlation with hyperlipidemia, diabetes mellitus or hypertension. Grafted coronary arteries were 6 anterior descending, one diagonal and one circumflex arteries. Diameter of them was 1.5 mm in one and 2 mm in 7. severity of stenosis of proximal coronary artery was 100% in one, 90-99% in one and less than 90% in 6. Undivided sizable costal or pericardial branches were found in 4 patients. All eight patients were alive without angina, although mild positive stress EKG changes were noted in two patients. In conclusion, a high resistance state such as a good competitive native coronary flow was thought to be the most important factor for the diffuse narrowing of IMAG, and close follow up should be needed because its outcome is still unknown.

Adult↗
PubMed1989

[Clinical experience of bovine internal mammary artery graft (BIOFLOW) for coronary artery bypass surgery].

Bovine internal mammary artery graft (BIOFLOW: BIOVASCULAR INC. Netherlands) has been used for coronary artery bypass grafting (CABG) in 8 patients since May 1988 at Osaka Medical College Hospital. There were 4 males and 4 females. Mean age was 66.9 year-old ranged from 62 to 72. Two were emergency CABG and other six had inadequate saphenous veins. The internal mammary artery and/or the saphenous vein were concomitantly used in all patients. Number of grafts was 2 to 6 with the mean of 2.9 and BIOFLOW (phi 3 mm) was anastomosed to 2 left anterior descending arteries and 6 right coronary arteries, the mean graft flow of BIOFLOW was 72.5 ml/min ranged from 52 to 120 ml/min. One patient died of ventricular arrhythmia on 5 postoperative day. There was no new Q wave infarction. Postoperative angiogram within 2 months showed 4 of 5 BIOFLOW grafts were patent, and no stenosis was found in those patent grafts. All survivors returned to home with a freedom from angina. From our experience, although the number was small and the follow-up period was short, BIOFLOW can be expected as an conduit of choice for CABG when the saphenous vein was not available and the internal mammary artery and the gastroepiploic artery were not enough to accomplish the complete revascularization.

Aged↗
PubMed1989

[Levels for discharge to home and return to general ward of patients who received therapeutic dose of 131I based on external exposure dose].

This paper describes levels for discharge from hospital and return to general ward of patients treated with 131I. The level was determined by comparing the possible exposure dose to those individuals whom the patients are in daily contact with the annual dose limit for the public. The external exposure dose was calculated by using the data on the distance between the patient and individuals, length of the time spent at each distance, and each individual's age. The following levels were obtained: (1) For the patient to be discharged from the hospital, the maximum residual radioactivity should be less than 0.51 GBq if the distance from the patient in bedroom is 50 cm or more and the ages of her children are all over one year. No restriction is needed for the patient with residual radioactivity of 0.20 GBq. (2) For the patient to be returned to the general ward, the maximum residual radioactivities should be 28 MBq and 41 MBq, corresponding to the distance from the patient of 2.0 m and 2.5 m respectively. We established a method to analyze the factors affecting the level.

Adolescent↗