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Biomedical subjects

A Takeda

Publications and source records attributed to A Takeda.

At least 397 records · Page 22Linked to original sources
PubMed1991

Clinicopathological findings of bucillamine-induced nephrotic syndrome in patients with rheumatoid arthritis.

This paper describes pathological and clinical investigations of glomerular lesions in bucillamine-induced nephropathy by analyzing biopsy materials from 9 patients with rheumatoid arthritis (RA). There was no specific predisposition for nephrotic syndrome induced by bucillamine in clinical profiles related to age, onset, duration of disease, sex, activity and dose of bucillamine. In light-microscopic, electron-microscopic and immunofluorescent findings, the characteristic changes were similar to those of idiopathic membranous glomerulonephritis (MGN). After discontinuance of bucillamine, the nephrotic syndrome improved slowly with or without corticosteroid therapy. Results confirmed that the most common lesion of nephrotic syndrome associated with bucillamine therapy in RA is MGN. We recommend that corticosteroid therapy should be restricted to cases with severe proteinuria.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1991

Detection and identification of loline and its analogues in horse urine.

Several kinds of loline-type alkaloids, norloline, loline, N-acetylnorloline, N-acetylloline, N-formylnorloline, N-formylloline and N-methylloline were detected in the urine of race-horses. Furthermore, a new compound of the alkaloids, N-senecioylnorloline, was also found and identified. These compounds were mainly identified by means of gas chromatography-mass spectrometry (GC-MS) and gas chromatography-fourier transform-infrared spectrometry (GC-FT-IR). A certain plant of Gramineae containing four kinds of loline-type alkaloids was found in a bale of hay used for the horse forage. The taxonomic feature of the plant was different from known plants containing loline-type alkaloids. The common fragmentation of loline-type alkaloids under electron ionization was briefly discussed.

Alkaloids↗
PubMed1991

Nucleotide sequence of the putative human tyrosinase pseudogene.

We have cloned and sequenced the putative human tyrosinase pseudogene, which shares more than 98% nucleotide homology with exon 4 and exon 5 of the human tyrosinase gene including their flanking introns. Because of such a high homology, both the tyrosinase gene and its pseudogene could be amplified from genomic DNA by polymerase chain reaction. The nucleotide sequences presented thus enable us to discriminate the tyrosinase gene from its related sequences and are invaluable for a gene diagnosis of oculocutaneous albinism.

Base Sequence↗
PubMed1991

[Statistical study of endodontically treated teeth by undergraduate students from 1979 to 1989].

In clinical education in dentistry, it is very important and significant that the undergraduate students themselves treat the patients. According to the rapid progress of dental science, the complexity and the high degree of the quality of education increase more and more, so that it is a requisite to make our efforts to enrich the quality of the practice at all times. In this paper, we investigated and statistically analyzed the result of 3,359 cases (test cases: 304, general cases: 3,055) which were treated endodontically by the undergraduate students of Tokyo Medical and Dental University in the four classes of 1979, 1982, 1986 and 1989. Both the number of the treated cases and the patients decreased year by year. Only the patients above sixty years old showed a tendency to increase in number. The result of the test cases was not always representative of the result of the general cases. If the clinical instructors for the undergraduate students grasp the detailed results of this study, we can expect that they can guide and train the undergraduate students more effectively.

Adult↗
PubMed1991

[Clinical studies on acute uncomplicated cystitis in women].

A total of 499 female patients with acute uncomplicated cystitis were observed and analyzed clinically for age distribution, characteristics of symptoms, bacterial culture of urine, behavioral aspects of recurrent cystitis and others. The patients were between 3 years and 88 years old (average: 43 years) and the majority of patients were from 20 to 69 years old. From 81.1% of the patients Escherichia coli was detected, followed by Staphylococcus spp (11.2%). The major symptoms were pain on urination (421 cases), urinary frequency (421 cases) and residual urine sensation (418 cases). The major causes of cystitis as reported by the patient were fatigue (131 cases), infrequent voiding (114 cases) and exposing the body to coldness (103); only 42 patients reported a relationship between sexual intercourse and cystitis. The patients who had been suffering from "honeymoon cystitis" were significantly inclined to be suffering from acute uncomplicated cystitis again in comparison with those who had not suffered from honeymoon cystitis. There was suggested to be a relationship between sexual intercourse and recurrent cystitis.

Acute Disease↗
PubMed1991

[Experimental study of the relationship between in vitro binding activity and in vivo tumor accumulation of radiolabeled anti-CEA monoclonal antibodies].

The immunoreactivity and affinity of seven kinds of monoclonal antibody raised against human gastric cancer (MKN-45) secreted carcinoembryonic antigen (CEA) were determined with the method of cell binding assay in vitro. Tumor localization and biodistribution of radiolabeled antibodies were performed in athymic mice implanted MKN-45 xenografts. Results obtained were as follows: 1) The affinity constant of CEA-specific three antibodies (1A4, 1B2, 4H11) was the same approximately, whereas the immunoreactivity found to be quite different among them. While CEA-nonspecific four antibodies (7D1, 6C7, 2C3, 5H7) showed the much higher affinity constant than that of the former. 2) In an animal model on tumor localization and biodistribution studies, CEA-specific antibodies obtained more highly tumor targeting and cleared more rapidly from the blood and non-tumor organs than CEA-nonspecific antibodies did, so that tumor to nontumor ratios was increased. 3) In this model system it is the immunoreactivity preparation of antibodies that improved tumor targeting and tumor activity retention, on the other side, the affinity constant of antibodies were associated with rapid clearance from the blood and non tumor sites. In conclusion, this studies would also be beneficial for practical use and clinical application of radiolabeled monoclonal antibodies.

Animals↗
PubMed1991

[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].

UNLABELLED: The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB). While AED serum concentrations were low in most cases of VPA, PHT and PB except for one case of VPA which exceeded therapeutic limits, concentrations were within therapeutic levels in many cases of CBZ. CONCLUSION: When compared with normal controls, abnormal deliveries such as caesarian section were seen more frequently in epileptic mothers under AED treatment. In addition, infants in PB cases were shown to have significantly lower mean birth length, weight and head circumference, suggesting that PB may retard fetal growth. The incidence of malformation in cases of VPA, PHT, CBZ and PB, was 10.3%, 5.0%, 0% and 6.7%, respectively. There were five types of malformation: in VPA cases, spina bifida, Siamese twins and ventricular septal defect tended to be severe, while in PHT and PB cases, cor biloculare and hypospadias respectively were observed. In cases of VPA, serum levels in the umbilical cord were found to be 150% higher than those in the mother.

Abnormalities, Drug-Induced↗
PubMed1991

[Ipsilateral synchronous renal pelvic transitional cell carcinoma and renal cell carcinoma: a case report and review of the literature].

A case of ipsilateral transitional cell carcinoma of left renal pelvis and left-renal cell carcinoma is presented. A 75-year-old male consulted our hospital with the complaint of painless gross-hematuria which had persisted for four years. Excretory urography revealed left non-visualized kidney. Retrograde pyelography demonstrated the filling defect, which had an irregular border, in the left renal pelvis. The selective left renal arteriography revealed the hypervascular region in the left renal cortex. Intraarterial chemotherapy with CDDP, MTX and ADR was performed preoperatively. Then, total left nephroureterectomy and segmental resection of the bladder was done. The surgical specimen was pathologically diagnosed as transitional cell carcinoma of the renal pelvis and renal cell carcinoma of the left kidney. This case is the 23rd reported case of ipsilateral synchronous renal malignancy in Japan.

Aged↗
PubMed1991

The kidney disease of Crow-Fukase (POEMS) syndrome: a clinico-pathological study of four cases.

We studied four cases of Crow-Fukase syndrome with renal dysfunction. Kidney specimens obtained by needle biopsy showed glomerular lesions resembling those seen in conditions characterized by microangiopathy. Common glomerular findings by light microscopy were mesangial expansion and narrowing of the capillary lumina. An enlarged subendothelial space and mesangial area with deposition of amorphous material as well as swelling and vacuolization of endothelial cells were observed by electron microscopy. In an active phase, severe mesangial edema and segmental mesangiolysis, and in a late stage, mesangial cell interposition and sclerosis were seen. Tests by immunofluorescence microscopy for the presence of immunoglobulins A, M, G, lambda and kappa light chains, C3, and C4 were negative. Decay accelerating factor was found in glomeruli and in the vascular pole. Other findings included lymph node angiosclerosis, peripheral nerve microangiopathy and hemangioma formation with endothelial cell proliferation. These observations suggest that chronic endothelial injury constitutes the basic pathology of Crow-Fukase syndrome. Hemodialysis was required to manage anasarca in three of the patients although serum creatinine levels were below 5.0 mg/dl. Urinalysis revealed mild abnormalities and did not reflect the severity of the glomerular lesion. Corticosteroids given to three of the patients were effective in controlling fever and the lymphadenopathy; in two cases the corticosteroids induced a recovery of renal function. Thus Crow-Fukase syndrome may be due to chronic endothelial injury; the clinical symptoms and renal involvement respond to corticosteroid therapy.

Aged↗
PubMed1991

[A case of retroperitoneal venous aneurysm].

Venous aneurysm is a rare entity and the disease occurring in the retroperitoneal space has been reported in only 4 cases. Therefore, the fifth case of retroperitoneal venous aneurysm on the literature was described. A 59-year-old male was referred to our clinic because of painless large mass in the left abdomen. Computed tomography, ultrasonography, and magnetic resonance imaging revealed a cystic mass at the perinephric space. The resected cyst contained yellow-grayish fluid. The cyst wall was microscopically formed of 4 layers; blood and cholesterin, hyaline, muscle and collagen from the inner to outer side. He is well without any trouble after the operation.

Aneurysm↗
PubMed1991

[Clinical study of amaurosis fugax].

Nineteen cases of amaurosis fugax (AF) were analyzed in clinical study undertaken to address the problem of its pathogenetic mechanism. This series comprised 10 male and 9 female with an age range of 26-77 years. In 8 cases, AF was the only clinical manifestation, while in the other 11, AF was accompanied by hemispheric TIA. The attack lasted for a few to 15 minutes on most occasions, occurring on the left side in 7 cases and on the right in 12 cases. On the basis of cerebral angiographic findings and findings on transcranial Doppler blood velocity measurements (TCD), these cases were classified into 4 types of different etiology, i.e. (Group A) micro-embolus via internal carotid artery origin--7 cases (5 with stenosis at the level of siphon, 2 with stenosis of the ophthalmic artery); on TCD the direction of blood flow in ophthalmic artery was normal (forward flow) in 5 cases and antiplatelet therapy proved effective in 4 cases, (Group B) micro-embolus derived via the external carotid artery--5 cases (3 with complete occlusion of internal carotid artery at its origin, 2 with severe stenosis there of); TCD showed blood flow in the ophthalmic artery to be in a direction opposite to the normal (away flow) in 3 cases and 3 cases responded favorably to antiplatelet therapy, (Group C) cerebral hemodynamic crisis--3 cases (severe cardiac hypofunction following myocardial infarction, orthostatic hypotension, and elongation of internal carotid artery), and (Group D) unknown etiology--4 cases; cerebral angiography revealed no abnormalities, suggesting involvement of other factors than cerebrovascular agents.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[The hemodynamic and metabolic changes following tourniquet release during halothane anesthesia].

We measured the hemodynamic and metabolic changes following the release of lower limb tourniquet during halothane anesthesia, and discussed the cause of reduction in the blood pressure and the effective method for prevention. Cardiac index decreased transiently following the release, and gradually increased afterward. Systemic vascular resistance index decreased continuously and progressively until 10 minutes after the release. These results indicate that the causative factors of reduction in the blood pressure are temporary decrease in cardiac output and subsequent decrease in systemic vascular resistance. In mixed venous blood, pH decreased, PCO2 increased and HCO3- remained unchanged after the release. It seems that pH reduction was chiefly caused by the increase in PO2. Thus, the preventive method for reduction in the blood pressure following the tourniquet release may be as follows; 1) intravenous fluid loading, 2) hyperventilation, 3) elevation of lower limb, 4) lightning the anesthesia, and 5) finally giving vasopressors.

Anesthesia, Inhalation↗
PubMed1991

[Rapid deterioration of renal function in minimal change nephrotic syndrome].

This report concerns two boys with minimal change nephrotic syndrome progressed to renal failure. The first case aged 17 being a steroid sensitive infrequent relapse developed acute renal failure at his third relapse and recovered soon after the treatment with diuretics and corticosteroids. The second case aged 15 being a steroid dependent frequent relapse became steroid resistant at his 11th relapse and progressed to renal failure seven months later. As the causes of renal failure, acute tubular necrosis and tubular obstruction by casts were suspected in the former. Renal vein thrombosis, morphological transition of renal histology, hemodynamic change and change in glomerular permeability might be occurred in the latter. Renal failure is a rare complication of minimal change nephrotic syndrome and the cause is variable. Precise diagnosis and prompt treatment should be needed to improve the prognosis.

Acute Kidney Injury↗
PubMed1991

[Clinicopathological study of midbrain corectopia].

A clinicopathological study was conducted in 19 cases (including 9 autopsied) of midbrain corectopia (oval pupil) occurring in the acute stage of cerebrovascular disorders. This ocular symptom manifested itself in conjunction with severe impairment of consciousness invariably in all instances, unilaterally in 11 and bilaterally in 8 cases, with the shape of the pupil and the direction of its displacement varying from case to case. In 17 cases, this patients died several hours to several days after the appearance of this sign. On autopsy were noted small hemorrhagic lesion of the upper mesencephalic tegmentum in 2 cases and conspicuous cerebral herniation in 7 cases. In this study, it was thought that all cases had diffuse lesions including nuclear, infra- and/or supra-nuclear parts of the midbrain. Clinicopathologically, it was difficult to define the corresponding lesion for corectopia. We suggested that this ocular symptom which appeared transiently was the sign of poor prognosis.

Adult↗
PubMed1991

[A case of spontaneous cervical vertebral artery dissection resulting in Wallenberg's syndrome--diagnostic value of the cervical axial MRI].

Findings of the cervical axial MRI are discussed in a case of spontaneous cervical vertebral artery dissection resulting in Wallenberg's syndrome. A 42-year-old male was hospitalized because of sudden onset of severe occipital pain. Cerebral angiography performed on the day of admission revealed severe tapering stenosis of the right vertebral artery at the C-5 level of the vertebra. Angiography repeated 50 days later showed partial resolution of the narrowing. T-1 weighted axial MRI of the neck demonstrated significantly narrowing flow void of the right vertebral artery when compared with the contralateral side. A crescent-like high intensity area was also seen surrounding the lumen. These findings were consistent with hematoma within the dissected wall of the vertebral artery. MRI is considered useful in identifying such vascular lesions as cerebral artery dissection.

Adult↗