Biomedical subjects

A Tajiri

Publications and source records attributed to A Tajiri.

21 records · Page 2Linked to original sources

PubMed1980

Magnetic circular dichroism and circular dichroism of some nucleosides.

The magnetic circular dichroism and circular dichroism spectra of cytidine, isocytidine, 2,5'-O-cyclo-2',3'-O-isopropylidine uridine, and 2,2'-O-cyclouridine were measured in the wavenumber region of 30000 -50000 cm-1. On the basis of the experimental results, the tautomerism of cytidine and isocytidine was discussed. The transition energies, the oscillator strengths, and the Faraday parameters were calculated within the framework of the INDO approximation. The calculated results are in good agreement with the experimental results. And then the spectral assignment of the pyrimidin nucleosides, together with those of cytosine and isocytosine, were discussed on the basis of the experimental and theoretical results.

Circular Dichroism↗

PubMedDate not supplied

Heparin bonding of the extracorporeal circuit reduces thrombosis during prolonged lung assist in goats.

This study investigated whether an artificial membrane lung of nonmicroporous polyolefin hollow fibers bonded with heparin could prolong venoarterial extracorporeal lung assist (ECLA) with low dose systemic heparin in goats. We compared heparin bonded circuits (Carmeda Bioactive Surface, "HB" group, n = 5) with non heparin bonded circuits ("NHB" group, n = 5) in venoarterial ECLA (V-A ECLA) for 7 days. Activated coagulation time (ACT) was maintained at approximately 130 sec by systemic infusion of small doses of heparin in the HB group, and at 200-230 sec in the NHB group. Thrombus formation was assessed by visual examination of the circuit, and possible cerebral embolization of thrombi was observed from behavioral abnormalities of the animals. The mean heparin dose given during ECLA was 20.4 +/- 3.6 U/kg per hr in HB, and 50.9 +/- 14.2 U/kg per hr in NHB, significantly less in HB than NHB (p < 0.01). Blood gas changes across the oxygenator, bypass flow rate, platelet aggregation activity, platelet counts, fibrin monomer (FM) test, and antithrombin-III (AT-III) activity did not differ between the two groups. In HB, thrombi were fewer and no abnormal neurologic symptoms were observed during ECLA. Numerous thrombi were observed in all oxygenators with NHB. One NHB goat developed convulsions and cerebral hemorrhage on the 6th day of ECLA. Nonmicroporous polyolefin hollow fibers can be bonded with heparin. An artificial membrane lung constructed of these fibers showed good anticoagulation by decreased thrombus formation with a small dose of infused heparin.

Animals↗

PubMedDate not supplied

A prospective survey of serial maternal serum zinc levels and pregnancy outcome.

Serum zinc levels were monitored serially in pregnant women. Compared with those of age-matched nonpregnant women, their serum zinc levels were significantly decreased in the first trimester (p less than 0.005) and further decreased in the second trimester (p less than 0.005) but then remained unchanged until delivery. Cord blood zinc levels and the ratio of cord blood to maternal serum zinc at delivery were significantly higher in preterm than term (greater than or equal to 37 weeks) infants (p less than 0.05, p less than 0.05). The maternal serum zinc level in the second trimester was not related to the birth weights of the infants. Mothers with serum zinc levels of less than 65 micrograms/dl in the last trimester showed a higher incidence of birth weights of less than the 50th percentile (p less than 0.005) and also of less than the 25th percentile (p less than 0.005) on term delivery. The incidences of birth weights of less than the 10th percentile on term delivery were similar for mothers with serum zinc levels of greater than or equal to 65 micrograms/dl. This observation suggested that a relatively lower birth weight may be associated with lower maternal serum zinc levels in the third trimester, but an additional factor (factors) is also involved in the outcome of low birth weight infants.

Birth Weight↗