This study aims to investigate the effects of ulinastatin, a human urinary trypsin inhibitor, on the cutaneous microcirculation during inhalation of 100% oxygen in the rabbit. Twenty-one rabbits having a rabbit ear chamber (REC), were divided into 2 groups: 11 rabbits without ulinastain treatment (Group C) and 10 rabbits with ulinastatin (Group U). After air inhalation, the inspired gas was changed to 100% oxygen. In Group U, 50,000 units of ulinastatin were administered before changing the concentration of inspired gas. The results suggests that ulinastatin may be useful for maintaining the cutaneous microcirculation during inhalation of 100% oxygen.

Animals↗

PubMedDate not supplied

Effect of inhalation of nitrous oxide on rabbit ear chamber microvessels.

The purpose of this study is to investigate the effect of inhalation of nitrous oxide (N2O) on peripheral hemodynamics in vivo. We observed changes in the peripheral microcirculation before and during inhalation of 70% N2O -30% O2 for 2 hours, using rabbit ear chamber method in 16 rabbits. In summary, inhalation of N2O causes decrease of the diameters, blood-flow velocities, and blood-flow rates of arterioles; thus participating in the increase of systemic vascular resistance gradually during the first 5 minutes of N2O inhalation. This phenomenon (arteriole vasoconstriction) was maintained for 2 hours.

Administration, Inhalation↗