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A Tafuri

Publications and source records attributed to A Tafuri.

61 records · Page 4Linked to original sources
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[Evaluation of the reproductive endocrine system in a population of hemodialyzed adult males].

There is a high incidence of sexual disorders of multifactorial origin in hemodialysed patients. The endocrine reproduction system was evaluated in 19 male adult hemodialysed patients. Slightly enhanced levels of prolactin and gonadotropins were found together with normal levels of total and free testosterone. Androgen biosynthesis intermediates were substantially normal. Hypophyseal stimulation tests using TRH and GnRH revealed a prolactin and gonadotropins response which was reduced, slow and protracted compared to normal. Hypophyseal stimulation did not cause any variation in testosterone levels. Prolactin and gonadotropins were not pulsatile. Data obtained appear to indicate that the hormonal component in sexual disorders in uremic patients is related to dynamic alterations of the system rather than basic hormonal changes.

Adult↗
PubMedDate not supplied

Hematopoiesis and growth factors in elderly cancer patients.

Hemopoietic Growth Factors (GF) are glycoprotein hormones that regulate the proliferation and differentiation of hematopoietic progenitor cells and of mature blood cell function. In last years GFs have moved from the laboratory study to the clinical area, and most of them have been produced on a large scale through recombinant DNA technology. Hemopoiesis and GF sensitivity of marrow cells declines with age, impairing the ability of elderly people to increase the production of GFs under stress conditions. In elderly cancer patients chemotherapy-associated neutropenia very frequently causes fever or infection with dose delay and increased morbidity and mortality rate, therefore in this setting beneficial effects of adjunct treatment with GFs have been proposed. Since reduction in neutropenia and in the risk of infection does not necessarily result in improved remission rate and long-term survival, some recommendations on the use (or abuse) of GFs are reviewed in this paper.

Aged↗