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Biomedical subjects

A Taïeb

Publications and source records attributed to A Taïeb.

At least 163 records · Page 9Linked to original sources

Gianotti-Crosti syndrome: a study of 26 cases.

We have studied 26 patients presenting with a symmetrical papular or papulovesicular acrolocated eruption of more than 10 days duration. Mean age at onset was 2 years (range 10 months to 5.75 years). Lymphadenopathy was noted in eight cases, and hepatomegaly in one case. In 12 cases, histopathology and direct immunofluorescence were non-contributory. Cytolytic hepatitis occurred in one case and was associated with HBs antigenemia. A history of recent immunization was given in two cases. There was serological evidence of recent Epstein-Barr virus infection in seven out of 13 cases tested. Coxsackie B viruses were isolated from three patients, and cytomegalovirus was probably associated with the syndrome in one case. We conclude that the Gianotti-Crosti syndrome is not rare in France, and that non-hepatitis B virus (HBV)-associated cases are more frequent than the classical HBV-associated papular acrodermatitis of childhood.

Acrodermatitis↗

[Immediate treatment of bullous pemphigus with a corticosteroid-cyclophosphamide combination].

Optimal management of the patient with generalized bullous pemphigoid (BP) should both control the disease rapidly to avoid fluid losses and superinfection, and have minimal side-effects. Although their initial dosage is subject to some controversy, corticosteroids (CS) provide currently the basis of therapy. Immunosuppressants have been advocated to decrease CS dosages more rapidly and to reduce potential hazards of long-term systemic steroid therapy, because of their sparing effect on cumulated CS doses. They have a delayed activity ranging from three to six weeks after beginning of therapy. Chloraminophene has been used in most previous studies. The aim of this study was to assess retrospectively a combined CS-cyclophosphamide (CP) regimen. Ten patients with generalized BP were treated. In nine, dexamethasone sodium phosphate was given intravenously (mean: 1.56 mg/kg/day in prednisone equivalents; range: 1 to 1.90 mg/kg/day) at onset of treatment. Prednisolone was given orally when complete control--absence of any new lesion--was achieved. CP was given d'emblée at a daily dosage of 100 mg for at least 6 months when feasible (mean: 4 months; range 9 days to 15 months). Patients characteristics are summarized in table I. Results are shown in tables II and III. In brief, three deaths occurred following major side-effects of the drugs during the first three months of treatment. Further non lethal untoward effects included bone marrow toxicity due to CP and septicemia (4 patients). At the end of follow-up, 5 patients were in remission without treatment for 22 +/- 6 months and one was controlled with prednisolone alone.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Cortex Hormones↗

[Course of the dermatophytic spectrum in tinea capitis. Apropos of 124 cases seen in Bordeaux].

The purpose of this study was to evaluate the epidemiology of tinea capitis in the Bordeaux area (Dermatology Unit of the Hôpital des Enfants, Bordeaux) during a 6-year period (January, 1979 to December, 1984). Dermatophytic infection of the hair was proven by culture in 124 patients, 21 of whom had a negative potassium hydroxide direct examination. Age and sex distribution are shown in figure 1. One case was observed in a 15 days old infant, and 4 cases in adult females (3 young black mothers of affected children, 1 elderly white woman). Table I indicates the geographical origin of the patients and the isolates identified. The incidence of anthropophilic dermatophytes has increased from 13 p. 100 to 50 p. 100 since our previous survey (1975-1978). M. langeronii (29 cases), T. soudanense (19 cases) and T. violaceum (10 cases) were isolated mostly among African immigrants from Western tropical Africa and the Maghreb. However, 4 children of French origin without any history of previous sojourn in endemic areas developed tinea capitis due to M. langeronii; the source of contamination could not be determined. Zoophilic dermatophyte infection was mainly caused by M. canis (50 cases), with cats being the most frequent source of contamination. Family cases were frequent: 64 corresponding to 28 families. This may be due to either interhuman contamination or the presence of a contact pet animal in the family. The discussion is focused on: the shift in dermatophytic isolates from tinea capitis toward anthropophilic species, notably M. langeronii, mainly caused by an increased immigration from West Africa; the relevant clinical and mycological correlations.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Congenital cutaneous candidiasis: a case with review of the literature].

The clinical features of CCC are stereotyped. Twenty-two cases have been found in the literature. Skin lesions are present at birth (12/22) or within the first twelve hours of life (7/22) and sometimes later, up to the sixth day of life. Maculopapular lesions are the first to appear, followed by the more typical vesiculopustular rash and secondary desquamation. Involvement of the upper half of the body is frequent. Interestingly, palm and sole pustules are almost constant. Oral, periungueal and conjunctival lesions are rare. In most cases, healing occurs within ten days of topical treatment using either nystatin or imidazole derivatives. Rarely (2/22), systemic candidiasis may be associated and may progress to death because of lung or meningeal involvement. Differential diagnosis includes post-natal acquired candidiasis, infectious pustulosis-impetigo, herpes, varicella-, and syphilis. In the authors' experience, pustular erythema toxicum is the most difficult diagnosis to rule out and the value of the direct smear must be emphasized. The clinical picture of CCC correspond to intrauterine infection due to a specific chorioamnionitis, for the following reasons: the rash may occur at birth; experimental cutaneous candidiasis required from 2 to 7 days of incubation; C. albicans has already been demonstrated in the adnexae, even in cases with late onset; culture of C. albicans in multiple sites favours intrauterine infection. Ascending infection of the fetal skin by C. albicans via the birth canal occurs probably through intact membranes, but fissures or late amniocentesis may create a portal of entry. CCC is rare as compared with the frequent maternal carriage of C. albicans.(ABSTRACT TRUNCATED AT 250 WORDS)

Candidiasis, Cutaneous↗

Hair casts. A clinical and morphologic study.

Idiopathic hair casts are described in two girls aged 5 and 7 years. A 0.025% tretinoin lotion seemed effective in removing the casts. Investigations, including light microscopy and transmission electron microscopy, suggest an infrainfundibular origin for these lesions, because both inner and outer root sheath components were observed in the transverse sections of the casts. A comprehensive review of the literature enabled us to classify the patients into two distinct groups: group 1 consisted of patients with idiopathic disease, showing a diffuse pattern of involvement, and group 2 consisted of patients with disease secondary to a variety of inflammatory scalp disorders.

Bezoars↗

[Pediatric papular acrodermatitis and double primary infection by the hepatitis B virus and the Epstein-Barr virus].

A case of papular infantile acrodermatitis was evaluated in a twenty-two month-old child. Laboratory data showed the presence of a cytolytic hepatitis associated to an increase in circulating monocytes (1.500/mm3) with hyperbasophilic cells. Hepatitis B surface (HBs) antigen was detected in the serum, associated to anti-HBc antibodies of the IgM class, without detectable anti-HBs antibodies. Simultaneously, EBV serologic profiles were consistent with a primary infection. The authors review the clinical presentation of previously described cases according to their suspected cause, and discuss the etiologic role of both EBV and HBV in the hereby reported case.

Acrodermatitis↗

[Immature cutaneous hemangiomas. Epidemiologic study of 351 cases].

The purpose of this study was to determine the course of cutaneous immature angiomas in a population of 362 children examined in a pediatric dermatology unit from 1975 to 1982. 461 angiomas were observed in these patients: 110 were of the naevus flammaeus type (port wine stain) including 23 forehead salmon patches. 351 were immature angiomas (IA)--strawberry angiomas. 3.5 p. 100 of children were afflicted of two types of hemangiomas. Results concerning the 282 patients with 351 IA are detailed as followed: average follow-up: 2 years; sex-ratio M/S 1.9, most of them Caucasians. Prematurity (data obtained prospectively during 1982): 19 p. 100; clinical features: dermal: 253, subcutaneous: 35, mixed pattern 63; 2 IA or more were detected in 12 p. 100 of the patients; site: head and neck; 49 p. 100, trunk: 21 p. 100, upper limbs: 14.5 lower limbs: 12 p. 100, genitals 3.5 p. 100; maximal size during follow-up: less than 1 cm: 36 p. 100, between 1 and 3 cm: 43 p. 100, more than 3 cm; 21 p. 100; time of onset: 51 p. 100 were noted at birth, 35 p. 100 during the first month, 13 p. 100 after the first month. Course of untreated IA is shown in figure 1. At the end of follow-up, spontaneous evolution in 52 patients was judged; very good in 44 p. 100, good in 41 p. 100, poor or bad in 15 p. 100. Minor complications (ulceration, infection, bleeding) were observed in 12.8 p. 100. Functional impairment requiring therapy was present in 2/4 plantar IA, 3/30 eyelid IA, 3/3 IA with laryngeal involvement.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Pilomatrixoma (Malherbe's calcifying epithelioma). Apropos of 13 cases observed in 6 years].

Thirteen pilomatrixomas were seen over a six year period. These small benign cutaneous tumors are infrequent though not exceptional and occur mainly in children (mean age six years). The tumor's hard consistency, irregular shape and frequently cephalic location (nearly 50% of cases) are suggestive. Diagnosis is established upon histological examination which demonstrates irregularly shaped clusters of basophilic epithelial cells; these develop into highly suggestive momified areas with shadow cells and secondary calcification. Attention is drawn to the presence of hemorrhagic modifications in recent tumors and telangiectasia. Pilomatrixomas must be considered as suborganoid hamartomas arising from the primary hair-matrix germ cells. The treatment is minimal surgical excision.

Adolescent↗

[Pathological, clinical and radiological study of colonic lympho-reticulosarcoma. Report of 8 cases (author's transl)].

The authors report 8 cases of lympho-reticulosarcoma of the colon and emphasize the rareness of this tumour (10 percent of cases) compared with other localisations in the stomach and small intestine. Whether primary or secondary, lymphosarcoma of the colon has various radiological appearances, depending on the mode of development of the sarcoma in the wall of the colon. Mainly sub-mucosal, it may remain localised or extend to the whole of the colon, predominating in the ileo-coecal and recto-sigmoid regions. Localised tumour forms present either in the form of large polycyclic lacunae, sometimes invaginated or as vast ulcerations with irregular nodular margin, or as due to parietal infiltration and exoluminal development of the tumour mass and neighbouring adenopathy. It is sometimes confused with carcinoma of the colon, e.g. vegetating carcinoma, colloid carcinoma, or peritoneal metastases, or with a regional abscess, e.g. appendix abscess or diverticulosis. The correct diagnosis is made on operation. The extensive colonic forms rarely take on the appearance of lymphoid pseudopolyposis, more often that of a very unusual nodular form formed of hazy lenticular lacunae. It may be confused with nodular colitis, it differs from this, however, by the absence of ulceration, changes in caliber and the persistance of normal haustration, a reticulated appearance of the mucosal outline during evacuation of the barium. In all cases, the discovery of a colonic lympho-reticulosarcoma implies complete digestive radiological investigation in order to seek gastric, duodenal or intestinal localisations, together with a search for other extra-digestive localisations. In fact, the great diffusion of the lesions modifies the prognosis and the therapeutic attitude. These lymphosarcomas and reticulosarcomas of the colon have a similar pathological and radiological appearance but differ by their sensitivity to treatment with cobalt, as reticulosarcomas are more resistant.

Adult↗