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Biomedical subjects

A T Pedersen

Publications and source records attributed to A T Pedersen.

25 records · Page 2Linked to original sources
PubMed1983

Lingual infarction in giant cell arteritis. A case report.

Giant cell arteritis is a disease of the elderly, affecting the temporal or other cranial arteries, often in patients with polymyalgia rheumatica. A case of giant cell arteritis with necrosis of the tongue in a 77-year-old woman is reported. It is important to be aware of this condition because of the serious complications. As the lesion is focally distributed, it is necessary to obtain a large biopsy specimen from the superficial temporal artery in order to make a correct diagnosis. Prompt treatment with corticosteroid in large doses followed by a lower maintenance dose is important to prevent vascular complications.

Aged↗
PubMed1983

Antibodies against Aspergillus fumigatus in bronchial secretions from patients without aspergillosis.

Antibodies to Aspergillus fumigatus were investigated by indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA) in bronchial secretions (BS) and sera from 40 patients with neoplasia, lung infiltrates of non-fungal aetiology or chronic bronchitis. By IIF, IgG aspergillus antibodies were found in 23 samples of BS (58%) (titre range 10-40) and in all 40 sera (titre range 10-1280). IgA aspergillus antibodies were detected in 33 samples of BS (83%) (titre range 10-160) and in 33 sera (83%) (titre range 10-40). IgM aspergillus antibodies occurred in 2 samples of BS (5%) (titre 10 and 40) compared with 35 sera (88%) (titre range 10-40). Antibodies with secretory component (SC) were detected in 20 of 39 BS samples tested (51%) (titre range 10-160). Significantly higher levels of IgA antibodies were detected by ELISA in BS than in serum (2p less than 0.05) and, conversely, significantly higher levels of IgG antibodies were found in serum than in BS (2p less than 0.001). Low levels of antibodies with SC were also detected in BS by ELISA. These results suggest that aspergillus antibodies are produced within the bronchopulmonary system in patients without aspergillosis.

Antibodies, Fungal↗
PubMed1976

Epidemic shigellosis on a worktrain in Labrador.

An epidemic of shigellosis occurred on a worktrain in western Labrador in October 1974. During the outbreak 62 persons out of a crew of 91 became ill, 11 having recurrent illness; 14 were hospitalized. Epidemiologic analysis with laboratory confirmation implicated unchlorinated and contaminated lake water as the source of the epidemic. Faulty design of water storage tanks perpetuated the use of contaminated water; hence a second wave of illness occurred. The tanks were then thoroughly drained, cleaned and repaired. Many deficiencies in sanitation measures (most of which have since been rectified) were noted at the site of the epidemic as well as at other locations along the railway. Careful sanitation controls are essential in rapidly developing areas of northern Canada.

Disease Outbreaks↗