Search PubMed⌕ Search

Biomedical subjects

A T Chen

Publications and source records attributed to A T Chen.

50 records · Page 3Linked to original sources
PubMed1969

Centromeres in human meiotic chromosomes.

Two heterochromnatic spots were observed in most bivalents of human spermnatocytes at the late diplotene stage from six individuals. It is our belief that these dark staining bodies are the centromeres of the meiotic chromosomes.

Humans↗
PubMedDate not supplied

Prenatal diagnosis of pericentric inversion of chromosome No. 17 in a twin pregnancy.

Although prenatal genetic diagnosis can usually provide prospective parents with information as to whether their fetus is affected with certain genetic conditions, the presence of twins and the uncertainty about the phenotype of some chromosome variations pose a major dilemma and make genetic counseling very difficult. Here, a case report of an unusual chromosome aberration (pericentric inversion of chromosome no. 17) in a twin pregnancy which was originally suspected to be monoamniotic but later proved to have two sacs was presented.

Adult↗
PubMedDate not supplied

Human testicular cultures. II. Sertoli cells.

Two cell types, one epitheloid and the other fibroblast-like, were found in human testicular cultures derived from testes of patients. Ultrastructural studies indicated that, whereas the epitheloid cells were Sertoli cells, the fibroblast-like cells were fibroblasts. The Sertoli cells could maintain growth for a period of more than 4 months. In cultures derived from normal testes, only fibroblasts were observed.

Cell Membrane↗
PubMedDate not supplied

Detection of mosaicism in amniotic fluid cultures: a CYTO2000 collaborative study.

PURPOSE: To evaluate the assumptions on which the American College of Medical Genetics (ACMG) Standards and Guidelines for detecting mosaicism in amniotic fluid cultures are based. METHODS: Data from 653 cases of amniotic fluid mosaicism were collected from 26 laboratories. A chi-square goodness-of-fit test was used to compare the observed number of mosaic cases with the expected number based on binomial distribution theory. RESULTS: Comparison of observed data from the in situ colony cases with the expected distribution of cases detected based on the binomial distribution did not reveal a significant difference (P = 0.525). CONCLUSIONS: The empirical data fit the binomial distribution. Therefore, binomial theory can be used as an initial discussion point for determining whether ACMG Standards and Guidelines are adequate for detecting mosaicism.

Amniotic Fluid↗