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Biomedical subjects

A Suria

Publications and source records attributed to A Suria.

At least 37 records · Page 2Linked to original sources
PubMed1985

Elevated levels of gamma amino butyric acid (GABA) in the thymus gland during the immune response.

Innervation of the mammalian thymus gland by both cholinergic and catecholaminergic neuronal projections has been documented. The present results reveal that the inhibitory neurotransmitter, gamma amino butyric acid is also present in the mouse thymus and that it is significantly elevated following challenge with a T-cell dependent antigen. A possible immunomodulatory role for the neurotransmitter is discussed.

Adjuvants, Immunologic↗
PubMed1982

Effects of peripherally administered GABA and other amino acids on cardiopulmonary responses in anesthetized rats and dogs.

Intravenously administered GABA (1.0-1000 micrograms/kg) induced hypotension, bradycardia and tachypnea in both dogs and rats. The increased respiratory rate was not caused by changes in blood pH, pCO2, or pO2. None of the effects of GABA were modified by the following agents: propranolol, atropine, diphenhydramine, or hexamethonium. Taurine, glycine, beta-alanine, glutamic acid and aspartic acid at doses of 1000 micrograms/kg, i.v., had no significant effects on any of the variables measured. Since these doses of GABA probably do not cross the blood-brain barrier, it is postulated that the observed effects of GABA may be due to direct actions on vascular, cardiac and lung tissue. The exact site of GABA action in the periphery remains to be elucidated.

Amino Acids↗
PubMed1980

Carbamazepine.

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Animals↗
PubMed1980

Benzodiazepines.

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Animals↗
PubMed1979

Effects of picrotoxin, naloxone, and vagotomy on chlordiazepoxide-induced respiratory depression.

Intravenous administration of chlordiazepoxide (CDP) caused respiratory depression in both rats and cats. The maximally tolerated dose of CDP was found to be 165 +/- 15 mg/kg, i.v., in rats. Pretreatment with picrotoxin (1.5 mg/kg) or naloxone (20 mg/kg, i.v.) significantly increased the maximally tolerated dose of CDP to 330 +/- 40 mg/kg, i.v., and 270 +/- 35 mg/kg, i.v., respectively. The protective effects of both naloxone and picrotoxin were absent in bilaterally vagotomized rats. Naloxone pretreatment (25 mg/kg, i.v.) was also found to block the respiratory depressant effects of CDP in anesthetized cats, but had no effect on the cardiovascular actions of CDP. It is possible that the respiratory effects of CDP are due to its actions on GABA receptors, and that peripheral GABA receptors may mediate the protective actions of picrotoxin and naloxone.

Animals↗