Search PubMed⌕ Search

Biomedical subjects

A Sudo

Publications and source records attributed to A Sudo.

At least 55 records · Page 3Linked to original sources
PubMed1991

Chemotherapy of soft tissue sarcomas in the extremities.

A retrospective study on chemotherapy against soft-tissue sarcomas in the extremities was carried out on 98 patients. The local recurrence rate was 10.3% with intensive chemotherapy in post-1980 patients with high-grade sarcomas but 46.7% without chemotherapy--a fairly significant difference (P less than 0.01). The survival rate was significantly higher with intensive chemotherapy in post-1980 patients with high-grade sarcomas. Thus, intensive chemotherapy based on a new protocol should be given in cases of high-grade sarcoma. Considering surgical margin, the local recurrence rate was 33.3% in post-1980 cases inadequately operated upon but 8.6% in those adequately operated upon, which shows a significant difference (P less than 0.05).

Adolescent↗
PubMed1991

Current management, local management, and survival statistics of high-grade osteosarcoma. Experience in Japan.

To report the current management of high-grade osteosarcoma in Japan, the authors studied the results of 55 cases treated in the authors' institutions and data provided by Osaka University (59 cases), Chiba Oncology Group (97), and Sapporo National Hospital (70). Twenty-five of the 55 cases in the authors' series were treated by limb-salvage surgery, 27 by amputation, and the remainder by chemotherapy. In all 226 cases from the three institutes, 106 were treated by amputation and 120 by limb-salvage surgery. Two local recurrences (4%) were found in the authors' series, three in the Osaka series, and eight in the Chiba series. Five-year accumulative survival rates in this study showed some differences, depending upon the institution or upon the protocol employed: in the authors' series it was 60% overall and 68% for a stronger chemotherapy group; in the Osaka series, it was 50% in a mild chemotherapy group and 72% in an intensive chemotherapy group; and in the Sapporo series, it was 36% and 73%, respectively. This study showed that local control of IIB osteosarcoma was successfully achieved by preoperative adjuvant chemotherapy and wide resection, and that an intensive chemotherapeutic combination of high-dose methotrexate, cisplatinum, and doxorubicin is promising.

Adult↗
PubMed1990

Melorheostosis of the toe: a case report.

A case of melorheostosis in a 57-year-old Japanese woman is presented. This case is noteworthy because of its unusual radiographic features and local findings and its unusually long follow-up period of more than 29 years. Melorheostosis progresses very slowly over a long period of time, and can show bizarre features, simulating malignant tumor.

Female↗
PubMed1987

Adrenaline in various organs of the rat: its origin, location and diurnal fluctuation.

In order to examine the origin and location of adrenaline in peripheral organs of mammals, adrenaline and noradrenaline were measured in several organs of the rat after adrenalectomy, guanethidine treatment and imipramine injection. One week after bilateral adrenalectomy, adrenaline disappeared almost completely from the heart, spleen and submaxillary gland. Chronic administration of guanethidine caused decreases in both noradrenaline and adrenaline in the peripheral organs. Injection of imipramine induced a reduction of adrenaline concentration in the spleen and submaxillary gland. It is considered that adrenaline in the peripheral organs of mammals is mostly derived from the adrenal gland and that circulating adrenaline is taken up by sympathetic nerve endings in the organs. The adrenaline content of the peripheral organs increased after electric foot-shock and changed according to the time of day. The peak of the circadian rhythm appeared about 6 hours after the peak of the urinary adrenaline rhythm. These findings suggest that adrenaline in body organs plays some role in the responses of the sympathetic nervous system to stressful conditions or even to daily activities.

Animals↗
PubMed1987

Effects of adrenalectomy and chronic guanethidine treatment on tissue adrenaline concentrations in swimming-exposed rats.

Adrenaline is known to increase in extra-adrenal peripheral organs as well as urine and plasma in the rat after swimming stress. In order to clarify the physiological significance of adrenaline in stress responses, the origin and location of adrenaline in the peripheral organs were examined by measuring adrenaline in the heart, spleen, submaxillary gland and some other organs after adrenalectomy or guanethidine treatment. After bilateral adrenalectomy, adrenaline in the peripheral organs mostly disappeared. Swimming stress caused no increase in the adrenaline content of the organs in the adrenalectomized rats, while a marked increase was observed in the sham-operated animals. In guanethidine-treated rats, the adrenaline content of the peripheral organs was extremely low as compared to that in the saline-treated animals, and the swimming-induced increase in adrenaline level in the organs was greatly suppressed. These observations suggest that the organ adrenaline, which exists in sympathetic nerve endings, is mostly derived from the adrenal gland. It is considered that adrenaline would be involved in sympathetic neurotransmission, especially under stressful conditions.

Adrenalectomy↗
PubMed1986

[Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016, bifemelane hydrochloride) on coagulation, fibrinolysis, hemolysis, hemorheological properties and platelet aggregation].

MCI-2016 showed little influence on coagulation (APTT) and fibrinolysis (plasma clot lysis activated by urokinase) at doses (concentrations) as high as 300 mg/kg, p.o. or 8.6 X 10(-4) M. Hemolytic action of MCI-2016 was only observed at the concentrations above 2 mM. The drug also showed no influence on blood glucose level (30-300 mg/kg, p.o.). Effects of MCI-2016 on hemorheological properties were studied either in vitro or ex vivo. Above the doses (concentrations) of 100 mg/kg, p.o. and 10 microM, MCI-2016 suppressed the mechanical hemolysis and accelerated the membrane filtration rate. These effects of MCI-2016 were superior to those of cinepazide, Ca-hopantenate, meclofenoxate and pentoxyfylline. MCI-2016 also inhibited platelet aggregation induced by collagen with the IC 50 of 35 to 60 microM (rabbit and human platelets). Secondary aggregations of ADP and epinephrine were also inhibited by MCI-2016. As for reference drugs, bencyclane showed inhibitory patterns similar to MCI-2016. Other drugs examined exhibited little effect. In summary, it may be suggested that MCI-2016 exhibits beneficial influences in the clinical fields of cerebrovascular diseases.

Animals↗
PubMed1985

Decrease in adrenaline content of various organs of the rat after 6-hydroxydopamine.

To examine the location of adrenaline in peripheral organs of mammals, adrenaline and noradrenaline were measured in several organs of rats treated with 6-hydroxydopamine (6-OHDA) or vehicle. After the administration of 6-OHDA, there was a marked decrease in the content of both adrenaline and noradrenaline in the heart, spleen, submaxillary gland of the rat. This finding suggests that in rats adrenaline is present in noradrenaline neurons in these organs.

Animals↗
PubMed1985

Accumulation of adrenaline in sympathetic nerve endings in various organs of the rat exposed to swimming stress.

Swimming produced a marked increase in adrenaline content, but produced no change or slight decrease in noradrenaline content in the heart, spleen and submaxillary gland of the rat. Pretreatment with desmethylimipramine abolished the swimming-induced increase in adrenaline in the three organs. It was also found that the administration of 6-hydroxydopamine caused almost complete depletion of both adrenaline and noradrenaline from these organs of control and swimming-treated rats. Furthermore, a differential centrifugation study revealed that the microsomal fraction had the highest concentrations of both adrenaline and noradrenaline in the heart and spleen of control and stress-treated rats. These findings suggest that adrenaline, like noradrenaline, exists in sympathetic nerve endings in the peripheral organs of the rats under basal conditions, and the adrenaline contents in the nerve endings are increased under stress situations.

Animals↗
PubMed1983

Time course of the changes of catecholamine levels in rat brain during swimming stress.

The time course of the changes in the levels of adrenaline, noradrenaline and dopamine was investigated in rat hypothalamus, ponsmedulla and midbrain during 4-h swimming at 35 degrees C. The adrenaline levels showed gradual decrease whereas the noradrenaline and dopamine levels were kept in almost steady-state during the swimming. These findings suggest that brainstem adrenaline levels are not so fast adaptive as the noradrenaline and dopamine levels under the stress.

Animals↗
PubMed1983

Changes in free amino acid contents of rat brain induced by exposure to methyl bromide.

Rats were exposed to methyl bromide (MB) for 24 h at 10-120 ppm or for 3 weeks at 1-10 ppm. Changes in free amino acid contents of rat midbrain were measured by high-performance liquid chromatography (HPLC). MB increased glutamine and aspartic acid contents dose-dependently by short-and long-term exposure. Alanine content was markedly increased by long-term exposure to 10 ppm MB. Glycine was dose-dependently increased, except at 120 ppm. The harmful effect of MB on the central nervous system is discussed in relation to the changes in amino acid metabolism.

Amino Acids↗