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Biomedical subjects

A Stuchlík

Publications and source records attributed to A Stuchlík.

2 recordsLinked to original sources

[Space and spatial orientation].

Space and spatial orientation has been a subject of interest of researchers for many years. Spatial orientation can be divided into cued navigation and place navigation. The latter requires more complex neuronal computations and is considered to be a model of higher cognitive functions in animals. Allothetic orientation is based on determining the location of the subject with respect to orientating cues and gradients in its surrounding. Idiothetic orientation involves integrating the information generated during active and passive self-motion in order to obtain the actual position of the subject with respect to the starting point. This article reviews the historical evolution of spatial concepts, the types of orientation, and their neuronal implementation. Description of the most widely used methods of studying mechanisms of spatial orientation is also included.

Animals↗

Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats.

Vigabatrin (VGB), an inhibitor of gamma-aminobutyric acid-aminotransferase, exhibits an antiepileptic effect but several studies indicate that its effect may be biphasic. A time course of an effect of a single injection of VGB on hippocampal epileptic afterdischarges (AD) elicited by an electric stimulation of the angular bundle was examined in adult rats with chronically implanted electrodes. VGB (600 or 1200 mg/kg intraperitoneally) proved to be an efficient anticonvulsant in the intervals of 24 and 48 h--duration of ADs was shortened and behavioral phenomena were less intense. In contrast, ADs were lengthened 4 h after administration. The biphasic effect of VGB was demonstrated, the initial proconvulsant effect might be due to a different onset of VGB action in individual brain structures, but an additional mechanism of action cannot be excluded.

Action Potentials↗