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Biomedical subjects

A Stuart

Publications and source records attributed to A Stuart.

At least 37 records · Page 2Linked to original sources

A latent trait approach to the development of persistent stuttering.

The premise that stuttering disorders develop according to the orthogenetic principle, preceding in a continuous, unilinear fashion from a state of relative lack of differentiation to a state of increasing differentiation and hierarchic integration, was examined. Responses to Woolf's Perceptions of Stuttering Inventory of 87 individuals who stutter were analyzed using a Rasch 1980 latent trait model for dichotomously scored data. Analyses of responses indicated struggle, avoidance, and expectation through the development of stuttering that became increasingly articulated, integrated, stable, and yet responsive to environmental changes. Four stages of development were noted: Stage I was characterized by the expectation of interruptions in the flow of speech, the addition of unnecessary sounds, and general body tension. Stage II was typified by distinctions between troublesome and not so troublesome words and sounds and between the speaker and various audiences and contexts for speaking. In Stage III, speech control decreased despite more focused and complex efforts to control the environment and the speech apparatus. Stage IV was characterized by automatic scanning of all speech, increasingly uncontrolled body movements, and attempts to produce fluent speech by way of comprehensive changes to sound, rhythm, and pitch. Follow-up of 29 respondents suggested the latent struggle was generally stable over time.

Adolescent↗

Recognition of temporally distorted words by listeners with and without a simulated hearing loss.

In separate experiments, word recognition performance of two groups of 12 normal-hearing young adults was investigated as a function of temporal distortion (i.e., time compression ratio or reverberation time) with and without a simulated high-frequency hearing loss (i.e., low-pass filtered at 2000 Hz). Performance decreased significantly as a function of increasing time compression, reverberation, and with the simulated hearing loss (p < .05). A statistically significant interaction between each of time compression ratio and reverberation time with the filtered listening condition was found (p < .05). This finding of an interactive, as opposed to a simple additive, effect of multiple distortions of the speech on word recognition performance suggests that loss of audibility alone cannot account for decrements in word recognition performance with time-altered speech. It is suggested that this multiplicative effect for combined acoustic distortions is a consequence of the functional loss of the high-frequency region of the cochlea. Not only is there a loss of audibility, but there is also a loss in temporal resolution capacity since it is perception mediated through the population of high-frequency auditory channels that has the best temporal resolution.

Adult↗

Effects of contralateral speech competition on auditory event-related potentials recorded from elderly listeners: brain map study.

Topographic brain mapping was used to investigate the ability of young and elderly female listeners to attend to tones at one ear in the presence of speech competition at the opposite ear. An oddball stimulus presentation paradigm was used to record the N1, P2, and P300 components of the late auditory evoked potential from 19 scalp locations. With speech competition, elderly listeners exhibited significantly larger reductions in N1 amplitude than did young listeners. This suggests that N1 may provide an electrophysiologic index of age-related breakdowns in processing sounds in the presence of background competition. An unexpected difference was also found between young and elderly listeners in P300 scalp topography. While the young listeners' P300 response was centered at midline for both left and right ear stimulation, the elderly participants had P300 maxima centered in the parietal area of the hemisphere located contralateral to the test ear. This suggests that some of the functional properties (e.g., timing, strength, orientation) of the P300 neural generators may change with age or, alternatively, that different generators may be operative in elderly listeners.

Adult↗

Effect of altered auditory feedback on people who stutter during scripted telephone conversations.

The effect of altered auditory feedback (AAF) conditions on stuttering during scripted telephone conversations was investigated. Nine adult participants made 15 scripted telephone calls to business in New York City. Alterations in the participants' auditory feedback signal were generated by a commercially available digital signal processor (Casa Futura Technologies Desktop Fluency System Model BTD-400) that shifted participants' speech one-half octave down in frequency, produced a 50-ms delay, or produced non-altered auditory feedback. The AAF effects produced by the digital signal processor were not perceived by the recipients of the telephone calls. The proportion of stuttering events per scripted telephone conversations were significantly reduced in the AAF conditions relative to the non-altered auditory feedback condition (p = .0004). Stuttering frequency was reduced by 55% and 60% for the FAF and DAF, respectively. These findings demonstrate the applicability of this technology to situations of daily living involving telephone use.

Adult↗

Effect of monaural and binaural altered auditory feedback on stuttering frequency.

The effect of monaural and binaural alterations in auditory feedback on stuttering frequency was investigated. Eleven participants who stutter read aloud under nonaltered auditory feedback (NAF) and monaural and binaural conditions of frequency altered feedback [(FAF), on-quarter octave shift upward] and delayed auditory feedback [(DAF), 50-ms delay] at a normal speech rate. Relative to the NAF condition, reductions in stuttering frequency of approximately 60%-75% were found with the altered auditory feedback conditions. Post hoc single-df comparisons revealed a reduction in stuttering frequency with altered auditory feedback versus NAF (p < 0.0001), a greater reduction in stuttering frequency for binaural compared to monaural altered auditory feedback (p = 0.028), and nonsignificant differences in stuttering frequencies for right versus left monaural conditions (p = 0.54) and DAF versus FAF (p = 0.70).

Adolescent↗

Formant frequency characteristics of elderly speakers in contextual speech.

The present study measured F1 and F2 formant frequency levels of elderly and young male and female speakers producing the /i/, /ae/, [symbol: see text], /u/, and /a/ vowels in two carrier phrases. Results of a series of ANOVAs showed significant interactions of speaker age x vowel for both F1 and F2 formant frequencies for the male and female speakers. Results suggested that while elderly male speakers exhibit significant alterations in vowel production during contextual speech, elderly female speakers generally maintain formant frequency integrity or appropriate articulatory posturing during contextual vowel productions.

Adult↗

Effect of speaking into a passive resonator on stuttering frequency.

The effect on stuttering frequency of speaking into a passive resonator was investigated. Eight participants who stuttered read aloud with and without the benefit of the resonator. A statistically significant reduction of approximately 30% in stuttering frequency was observed while the participants spoke with the resonator. These and similar commercially available devices may be employed with individuals who stutter, particularly children, as a means of enhancing fluency.

Adolescent↗

Word recognition in continuous noise, interrupted noise, and in quiet by normal-hearing listeners at two sensation levels.

The effect of presentation level on word recognition performance-intensity functions in continuous and interrupted broadband noise and in quiet was explored. Normal-hearing participants were tested at 30 and 50 dB sensation levels (SLs). Performance-intensity functions in both noises were determined at signal-to-noise ratios (S/Ns) of 10, 5, 0, -5, -10, -15, and -20 dB. There was no effect of SL presentation on word recognition performance in quiet (p = 0.136). A significant main effect was observed for S/N in both continuous and interrupted broadband noise conditions (p < 0.0001). Performance increased with increases in S/N regardless of the competing noise condition. A significant main effect for SL presentation was only observed in the interrupted noise condition (p = 0.0019). That is, performance was higher for the 50 SL for the interrupted noise condition only. It is suggested that the observed difference in performance in interrupted noise at different SLs offers additional evidence for level-dependent, temporal masking phenomena.

Hearing↗

Effect of frequency altered feedback and audience size on stuttering.

The effect of frequency altered feedback (FAF) and audience size on stuttering frequency was examined. Nine adults who stutter orally read to audiences of two, four and 15 people under conditions of FAF (one-half octave shift down) and non-altered auditory feedback (NAF). There was no statistically significant effect of audience size on stuttering frequency (p > 0.05). A statistically significant reduction in stuttering frequency was found under FAF relative to NAF (p < 0.5). Collapsed across audience conditions, stuttering frequency was reduced by 74%. These findings suggest that FAF may be useful as a treatment tool.

Adult↗

Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantation.

We evaluated the pharmacokinetics and pharmacodynamics of filgrastim during a Phase I study of this cytokine following high-dose chemotherapy and autologous bone marrow transplantation. Serum granulocyte colony-stimulating factor concentrations were determined by ELISA in 21 patients receiving 14-day continuous i.v. filgrastim infusions and 10 patients receiving daily 4-h infusions. Models were developed for filgrastim systemic clearance (Cls) by incorporation of receptor-binding theory. Mean plasma half-life (t1/2) in the 4-h infusion group was 197 min, and the volume of distribution approximated plasma volume. WBC counts transiently fell, then rebounded immediately postinfusion, which correlated with a delay in the disappearance of serum granulocyte colony-stimulating factor. The effect of WBC concentrations on filgrastim Cls was determined in patients receiving continuous infusions by segregation of study periods based on the presence of severe neutropenia. Clearance increased in all 14 patients receiving doses of 4-32 microgram/kg/day during WBC recovery. The effect of WBCs on Cls was described by a differential equation that included a static component and one component that varied with WBC concentration. These data suggest that currently used filgrastim dosing strategies following autologous bone marrow transplantation may be suboptimal.

Adult↗

Fluency effect of frequency alterations of plus/minus one-half and one-quarter octave shifts in auditory feedback of people who stutter.

The effect of frequency alterations in auditory feedback of people who stutter on stuttering frequency was investigated. Twelve participants who stutter read aloud under nonaltered auditory feedback (NAF) and four conditions of frequency-altered feedback ([FAF], plus/minus one-half and one-quarter octaves) at normal and fast speech rates. Stuttering frequency was significantly higher while reading aloud with NAF relative to the four conditions of FAF (p < 0.05). There were no differences among participants' stuttering frequency between the four FAF conditions (p > 0.05). Reductions in stuttering frequency of approximately 50% to 60% were found with FAF relative to NAF. More disfluencies occurred with the fast versus the normal speech rate condition (p = .0007) irrespective of auditory feedback condition. These findings suggest that slight alterations in the frequency of auditory feedback of people who stutter are fluency-enhancing.

Adult↗

Word recognition in continuous and interrupted broadband noise by young normal-hearing, older normal-hearing, and presbyacusic listeners.

OBJECTIVE: Word recognition performance in continuous and interrupted broadband noise was examined in young normal-hearing (YNH), older normal-hearing (ONH), and presbyacusic (older hearing-impaired [OHI]) listeners. DESIGN: Participants (N = 36) were presented with identical Northwestern University Auditory Test No. 6 stimuli at 30 dB sensation level re their respective speech reception thresholds. The speech stimuli were presented in quiet and in both competing noise conditions with signal to noise ratios (S/Ns) of 10, 5, 0, -5, -10, -15, and -20 dB. RESULTS: In general performance was superior in quiet, improved with increasing S/N, and was greater in the interrupted broadband noise than in the continuous broadband noise. Significant main effects of group and S/N were found in both competing noises (p < 0.0001). Post hoc pairwise comparisons revealed all groups performed differently, with superior performance being displayed by the YNH group followed by the ONH and OHI groups, respectively (p < 0.05). A significant group by S/N interaction was observed in only the interrupted noise condition (p = 0.019). The degree of change in word recognition performance as a function of S/N was greatest in the OHI group followed by the ONH group and the YNH group. CONCLUSIONS: Group effects observed in the interrupted noise would imply that the two older groups of listeners had an auditory temporal deficit relative to the YNH listeners. The paradigm reveals the patency of the temporal processes that are responsible for the perceptual advantage (i.e., a release from masking) a listener has in interrupted competing stimulus.

Adult↗

Fluent speech, fast articulatory rate, and delayed auditory feedback: creating a crisis for a scientific revolution?

In 1970 Kuhn argued that science does not progress through a process of accretion. It is typified, rather, by the successive emergence of different paradigms which during their reign dictate the direction of normal science's puzzle-solving activity. Normal science inevitably exposes an anomaly which violates expectations predicted by the reigning paradigm. The "crisis" evoking anomaly may induce a destructive/constructive paradigm change. Transformations from one paradigm to another constitute a scientific revolution and dictate the growth and maturation of a field. This paper suggests the recent finding, that stutterers experience enhancement of fluency while speaking under delayed auditory feedback at a fast articulatory rate, be viewed as an anomaly. By challenging the notion that a slowed speech rate is necessary for amelioration of stuttering, the anomalous finding may be perceived as a crisis in the study of stuttering.

Attention↗

Effect of instruction to sing on stuttering frequency at normal and fast rates.

Singing as a fluency-enhancing mechanism is well-established. The fluency derived by singing has been attributed to a reduced speech rate, memorized material, semantically reduced content, and an imposed rhythm. In this study, we attempted to address each of these explanations. 12 participants who stuttered were instructed to read or sing each of four different passages under the following conditions: reading at a normal rate, reading at a fast rate, singing at a normal rare, and singing at a fast rate. Participants exhibited a statistically significant increase in disfluencies while reading, i.e., participants displayed a 75% reduction in disfluency in the singing condition relative to the reading condition. There was no difference in stuttering frequency with rate conditions. Current findings suggest that stutterers are capable of internally generating fluent speech production by imposing idiosyncratic melodic structures or some derivation of melody when asked simply to sing. There is no claim that these participants were singing, as skills and capabilities varied tremendously, only that participants achieved dramatic enhancement of fluency after they were just asked to sing. Thus, the only intervening variable was the instruction to sing, which suggests the attempt to follow the instruction, no matter how futile, generated fluent speech. Since fluency was maintained in both the normal and fast rates of production, alternate central mechanisms must be held accountable for these findings.

Adolescent↗

Stuttering amelioration at various auditory feedback delays and speech rates.

The primary purpose of this study was to determine if the finding of Kalinowski et al. (1993) of dramatic reductions in stuttering under delayed auditory feedback (DAF) at normal and fast speech rates could be replicated. The second purpose was to determine if stuttering frequency is differentially affected by various delays in an attempt to identify the optimal delay for fluency enhancement for both normal and fast speech rates. Fourteen adult stutterers read eight different passages at either a normal or fast speech rate under non-altered auditory feedback (NAF) and DAF with delays of 25, 50 and 75 ms. Results showed that significant fluency enhancement occurred under DAF at both normal and fast speech rates at all DAF settings (p < 0.05). This finding corroborates the notion that a slowed rate of speech is not a necessary antecedent for fluency improvement under conditions of altered auditory feedback. In addition, the results indicated that 50 ms appears to be the shortest delay producing the maximum reduction in stuttering frequency.

Adolescent↗

Effect of single and combined altered auditory feedback on stuttering frequency at two speech rates.

The purpose of this study was to determine if combining delayed auditory feedback (DAF) and frequency altered feedback (FAF) would enhance fluency more than either DAF or FAF alone. Ten stutterers read at normal and fast speech rates under nonaltered auditory feedback (NAF), DAF (i.e., a 50 ms delay), FAF (i.e., a one half octave downward shift), and a combination of DAF and FAF [(COMBO), i.e., a 50 ms delay plus a one half octave downward shift]. Results indicated that stuttering frequency was significantly reduced under all altered auditory conditions at high speech rates relative to the NAF condition. There were, however, no significant differences between the altered auditory feedback conditions (i.e., DAF, FAF, and COMBO). It is suggested that further studies be undertaken to explore the combination of altered auditory feedback conditions, as it may be the case that a floor effect was demonstrated with the singular presentations of DAF and FAF and further improvements in fluency enhancement could not be exhibited in the combined condition. Finally, these findings support the notion that a slowed rate of speech is not necessary for fluency enhancement under conditions of altered auditory feedback.

Adult↗

A randomized trial of an education and support program for HIV-infected individuals.

OBJECTIVES: To assess the effectiveness of an intervention for providing information and support to HIV-positive donors on changes in their sexual behavior, and to assess which donor characteristics are predictive of behavior change. DESIGN: Subjects were randomly assigned to a structured intervention or community referral group. Follow-up assessments were conducted every 6 months. SETTING: New York City, New York, USA. PARTICIPANTS: A cohort of 271 HIV-infected persons who donated blood to the New York Blood Center. INTERVENTION: Donors randomized to the structured intervention program met individually with a nurse for counseling and were offered a six-session support group. The program was designed to provide information, encourage safer sexual behavior and provide support. MAIN OUTCOME MEASURES: Sexual behavior, psychological distress and psychological help seeking, and immune function. RESULTS: In both groups there was a large decrease over time in reports of unsafe sexual activity. However, more than 30% of participants in both groups reported unsafe sexual activity at the 1-year follow-up visit. Donors randomized to the structured intervention program did not report significantly more behavior change at the 1-year follow-up. CONCLUSIONS: Better programs to promote behavior change in seropositive individuals are needed.

Adult↗

Source localization for template implants with particular reference to stepping-source afterloaders.

Source localization from radiographs can be very difficult for template-guided implants if the needle images overlap. At UCSF several techniques to make this task easier have been developed. The techniques include selection of an optimum simulator gantry angle, use of different types of dummies, and differential dummy loading. In addition, several modifications have been made in our brachytherapy planning computer program to facilitate source entry. As a result of these improvements, source localization is now accomplished in much less time with improved accuracy.

Brachytherapy↗