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Biomedical subjects

A Stella

Publications and source records attributed to A Stella.

205 records · Page 12Linked to original sources
PubMedDate not supplied

Angiographic evaluation of the anatomic pattern of arterial obstructions in diabetic patients with critical limb ischaemia.

OBJECTIVE: The present study was undertaken to evaluate, by means of angiography, the anatomic pattern of arterial obstructions in the lower extremities of diabetic patients presenting with critical limb ischaemia. We particularly examined the differences in involvement of the foot arteries between patients with and without diabetes. PATIENTS AND METHODS: A group of 150 patients with limb-threatening ischaemia, manifested by rest pain and/or non-healing ischaemic ulcers or gangrene, underwent angiologic evaluation in prevision of vascular surgery. The patients, of whom 89 were suffering from diabetes, were examined by means of digital subtraction angiography using the Seldinger technique. In each patient, details of arterial tree were obtained from the aortoiliac to the foot arteries and the site and the extent of obstructions were determined blindly with the radiologist unaware of the patient's history of diabetes. RESULTS: Diabetic patients showed significantly more obstructions in the infrapopliteal arteries when compared to the patients without diabetes who had more pronounced involvement of aortoiliac and femoropopliteal arteries. Diabetic patients, moreover, showed a higher prevalence of obstruction in posterior tibial, peroneal and plantar arteries than the non-diabetics. At the time of presentation, the age of patients did not differ between the two groups but diabetic patients had more frequent ischaemic ulcers or gangrene and less rest pain than the non-diabetics. CONCLUSIONS: Our study confirms earlier reports carried out with non-angiographic methods indicating more frequent involvement of calf arteries in diabetic patients but disagrees with those which report that patients with diabetes have less occlusive disease in foot arteries.

Adult↗
PubMedDate not supplied

[Anomalies of the subrenal inferior vena cava in the surgery of non-specific and inflammatory abdominal aortic aneurysms].

The sub-renal abnormalities of the lower vena cava (LVC) (left LVC, double LVC) are determined by a deterioration of the alteration process of supra-cardinal veins. Though they are rare, it is necessary to look for them during surgery of abdominal aorta in order to lower the risk of iatrogenic venous injuries. You will find below the description of six cases of sub-renal lower vena cava abnormality (3 double LVC, 3 left LVC) associated with an abdominal aorta aneurism (4 non specific aneurisms, 2 inflammations ones) as well as the diagnostic aspects and the technical issues they cause during the reconstruction of a non specific and inflammation aneurism of the abdominal aorta.

Aortic Aneurysm, Abdominal↗
PubMedDate not supplied

Oxytocin receptor within the breast: biological function and distribution.

In the present work, first we reviewed and completed our previous experiments on the antiproliferative effect of oxytocin (OT) in breast cancer cell lines. In vitro, OT 10 nM and 100 nM inhibited cell proliferation of MDA-MB231 (human breast carcinoma) and TS/A (mouse mammary carcinoma) cell lines. In vivo, OT significantly reduced the growth of TS/A mammary tumors. Both effects are mediated by specific receptors (OTR) distributed on cell surface. Second, using immunohistochemistry and RT-PCR we detected OTR and OTR mRNA in normal and pathological breast tissue. There is no correlation among OTR presence in breast carcinomas and the age of patients, tumor stage, estrogen receptor positivity, oncogene expression and proliferation rate of the same tumor. On the contrary, progesterone and OTR expression are correlated. These data confirm our previous evidence of a role of OT and OTR in normal and neoplastic breast cells.

Adult↗