Search PubMed⌕ Search

Biomedical subjects

A Steib

Publications and source records attributed to A Steib.

65 records · Page 4Linked to original sources
PubMed1987

Lung development under the influence of thiourea and L-thyroxine. Retarding and toxic effects of thiourea.

Chick embryos were treated on day 17 of incubation with 32.8 mumol thiourea or 18.9 nmol L-thyroxine. As was already known from previous studies, hatching was delayed and accelerated, respectively, under these conditions. The premature induction of hatching by L-thyroxine was accompanied by an advanced development of the pulmonary structure and of the circulation and by a premature absorption of the parabronchial liquid. Thiourea exerted an opposite effect on these parameters. In several cases the structural formation of the parabronchii was suppressed after treatment with thiourea. Furthermore, parabronchial liquid accumulated in those embryos, the hatching of which was suppressed. It is suggested that these changes represent a toxic effect of thiourea rather than a retardation of pulmonary development.

Animals↗
PubMed1986

Preferential glutamine uptake in rat brain synaptic mitochondria.

Glutamine uptake has been studied in purified rat brain mitochondria of synaptic or non-synaptic origin. It was taken up by an active saturable transport mechanism, with an affinity two-times higher in synaptic than in non-synaptic mitochondria (Km = 0.45 and 0.94 mM, respectively). Vmax of uptake was 7-times higher in synaptic mitochondria (Vmax = 9.2 and 1.3 nmol/min per mg protein, respectively). Glutamine transport was found to be inhibited by L-glutamate (IC50 = 0.64 mM) as well as thiol reagents (mersalyl, N-ethylmaleimide). It is suggested that differential uptake of glutamine in mitochondria of synaptic or non-synaptic origin may be a major mechanism in the regulation of the synthesis of the neurotransmitter glutamate.

Animals↗
PubMed1986

[Anesthesia for surgery of insulinoma].

The difficulties of interpretation of blood sugar level changes during the postoperative period in the anaesthetic management of insulinoma are discussed. Several specific means reduced the errors in the assessment of the hyperglycemic rebound which occurred after the removal of the tumour. They consisted of continuous sugar infusion accorded to measured glucose levels, in order to maintain a constant blood sugar value between 50 and 70 mg X 100 ml-1 before removal of the insulinoma. Furthermore, analgesia was provided by high doses fentanyl. Sugar containing solutes were avoided during the procedure. Glucose levels rose slowly after tumour removal and reached 170 mg X 100 ml-1 at 120 min. This rebound was known to be of no help in ascertaining complete resection. Simultaneous determinations of blood glucose and insulin were obtained. The value of portal blood insulin was found to be normal (12.3 mU X l-1) 30 min after insulinoma removal. Turner's index calculated every 30 min decreased simultaneously (143) and reached a normal value at 120 min (39). These results, obtained during the surgical procedure all the more easily because of rapid laboratory procedures, could be better arguments in determining whether tumour removal has been complete.

Adenoma, Islet Cell↗
PubMed1986

[The Kontron ABT 4000 respirator. Description, working mechanism and evaluation].

The ABT 4000 ventilator is aimed at being used in operating theatres, as it can be used in an open or a closed circuit, as well as for short periods of artificial ventilation with room air with or without added oxygen. This paper gives a description of the apparatus easy to understand, as well as an analysis of the workings of this constant volume ventilator controlled by microprocessor.

Equipment Design↗
PubMed1985

[A case of pheochromocytoma with cardiac localization. Review of the literature].

In a 26-year old man who died post-operatively, post-mortem examination revealed the presence of a phaeochromocytoma located in the atrio-ventricular sulcus and involving the trunk and bifurcation branches of the left coronary artery. Pre-operative investigations, including whole-body computerized tomography, and exploratory laparotomy had failed to detect the tumour. In contrast with the case reported here, the 4 other cases previously published concerned intrapericardial phaeochromocytomas in contact with the posterior wall of the left atrium.

Adult↗
PubMed1985

[Electro-drug anesthesia. Clinical and hormonal effects of transcranial electrostimulation].

The French technique of anaesthesia by electrostimulation described in 1972 by Cara and coworkers, consists of transcranial electrostimulation by means of a high frequency current combined with administration of a neuroleptic drug, a benzodiazepine, a curare and nitrous oxide with oxygen. Fentanyl is also given by some authors. In order to assess the benefit of such electrostimulation, this study compared two randomized groups of ten patients, scheduled for abdominal and pelvic surgery. Both groups received the same drugs (i.e. droperidol, flunitrazepam, pancuronium and nitrous oxide with oxygen), whereas patients in group I were also submitted to electrostimulation. This study describes and discusses the clinical behaviour of patients and the hormonal reactions before, during and after surgery. In both groups, operative conditions were satisfactory. Recovery and onset of spontaneous ventilation were rapid and no patient had an unpleasant recall of the operation itself. However, most of them complained of postoperative pain. Electrostimulation did not reduce the quantity of drugs required during and after surgery. In both groups, circulatory activity was significantly increased. In group I, the arterial pressure and the heart rate were significantly higher than in group II during and after surgery. The hormonal reactions showed that in both groups adrenocorticotrophic hormone, growth hormone and antidiuretic hormone increased during surgery. Adrenocorticotrophic hormone concentration was higher in group I during the operation. The serum levels of cortisol decreased before surgery in group I and rose in both groups during and after laparotomy; prolactin increased before surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenocorticotropic Hormone↗
PubMed1985

[Drugs inhibiting complement activation].

Complement may be activated by anaesthetic agents as well as contrast media, and so could anaphylactoid reactions be induced. Efficient and harmless complement blocking agents were still lacking. The only agents actually used by anaesthetists were steroids and/or antifibrinolytic drugs. Other agents were not indicated in surgical patients because of their adverse effects and the impossibility of giving them by the intravenous route.

Adrenal Cortex Hormones↗
PubMed1984

[Accidental ingestion of a battery].

A case of accidental battery ingestion by a three-year old boy is reported. The possible complications are local (i.e. necrosis of tissues by leakage of the alkaline electrolyte, by electrical injury or by impaction of the battery) and general (mercury poisoning). Large diameter batteries impacted in the oesophagus need prompt removal. When the battery is located in the stomach, two attitudes are discussed: some authors allow it to progress through the gastrointestinal tract spontaneously under radiological control, others recommend rapid removal by endoscopy or surgery in order to avoid the complications above described.

Accidents, Home↗