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Biomedical subjects

A Starr

Publications and source records attributed to A Starr.

At least 199 records · Page 11Linked to original sources
PubMed1985

Emergency coronary artery bypass surgery after intracoronary thrombolysis for evolving myocardial infarction.

Sixteen patients underwent emergency coronary artery bypass surgery immediately after intracoronary streptokinase infusion for acute evolving myocardial infarction. Of these, 11 patients had 70% residual stenosis in the recanalised vessel, and in five thrombolysis was unsuccessful. There were no hospital deaths. All the patients sustained myocardial necrosis, the peak activity of creatine phosphokinase correlating with the time to reperfusion. Chest tube drainage (mean 960 ml) was significantly higher than for control patients but did not correlate with the total dosage of streptokinase. No patients had further myocardial infarction or developed recurrent angina. Selected patients may benefit from coronary bypass surgery after intracoronary streptokinase infusion. If necessary this may be performed immediately with low mortality and morbidity.

Adult↗
PubMed1985

Vibration and muscle contraction affect somatosensory evoked potentials.

We recorded potentials evoked by specific somatosensory stimuli over peripheral nerve, spinal cord, and cerebral cortex. Vibration attenuated spinal and cerebral potentials evoked by mixed nerve and muscle spindle stimulation; in one subject that was tested, there was no effect on cutaneous input. Presynaptic inhibition of Ia input in the spinal cord and muscle spindle receptor occupancy are probably the responsible mechanisms. In contrast, muscle contraction attenuated cerebral potentials to both cutaneous and muscle spindle afferent volleys; central mechanisms modulating neurons in the dorsal columns nuclei, thalamus, or cerebral cortex are probably responsible.

Achilles Tendon↗
PubMed1985

Coarctation of the aorta in patients younger than three months. A critique of the subclavian flap operation.

Unexpected and disappointing late results with the subclavian flap operation prompted this analysis of repair of coarctation in infants under 3 months of age. A total of 134 such patients underwent surgical repair since 1960 with 55 end-to-end anastomoses performed earlier in our experience (mean follow-up 5.0 years) and 67 subclavian flap angioplasty operations performed more recently (mean follow-up 2.0 years). The operative mortality was not significantly different (p = 0.3) between end-to-end anastomosis (29%) and subclavian flap angioplasty (19%), but it was significantly higher (p less than 0.01) in the first week of life (56%). Recurrent coarctation occurred in 16 cases, necessitating reoperation. The reoperation-free rates (with standard error) at 5 years for end-to-end anastomosis and subclavian flap angioplasty were 92% +/- 5% and 75% +/- 7%, respectively (p = 0.01). Eight of 10 patients who had reoperation after angioplasty had early recurrence with continued involution of the periductal tissues and growth of the posterior aortic ridge. Six patients who had recurrence after anastomosis demonstrated late anastomotic growth failure. The most common reoperation technique was patch aortoplasty (10 patients). The high incidence of early recurrence with subclavian flap angioplasty in infants under 3 months of age suggests end-to-end anastomosis as the procedure of choice when applicable.

Aorta, Thoracic↗
PubMed1985

Influence of age at operation on late results with subclavian flap aortoplasty.

Despite the popularity of subclavian flap aortoplasty for repair of aortic coarctation, reported experience and follow-up in neonates is surprisingly limited. This paucity of reports prompted this review of age-related late recurrence rates. Of 83 patients having subclavian flap aortoplasty from 1976 to 1983, 60 were less than 8 weeks of age at operation (mean 2.6 weeks). Operative and late mortality were 18% and 14%, respectively. After a mean follow-up of 26 months, 10 patients have experienced recurrent coarctation (a mean of 10 months elapsed between operations). For 23 patients older than 8 weeks of age at operation (mean 20 months), operative and late mortality were 13% and 10%, mean follow-up is 16 months, and no patient has yet experienced recurrence. Thus, 75% of infants less than 8 weeks of age at operation are free of recoarctation at 2 years, and 100% of older children are free of recoarctation at 2 years (p = 0.06). Review of the literature corroborates our findings. The difference in recurrence rates may be due to age-dependent involution of residual coarctation tissue unavoidably left in place during subclavian flap aortoplasty. We conclude that subclavian flap aortoplasty is effective for correction of coarctation in infants, but patients less than 8 weeks old have a significant risk of early recurrence. Based on this review and our recently reviewed experience with end-to-end anastomosis, our preference is to use the latter in this age group when technically feasible.

Age Factors↗
PubMed1985

Valvotomy for pulmonary atresia with intact ventricular septum. A disciplined approach to achieve a functioning right ventricle.

During the past 20 years, a consistent policy in applying early valvotomy has resulted in a unique opportunity to appraise the long-term results of this approach in pulmonary atresia with intact ventricular septum. Since 1964, 27 of 35 patients with pulmonary atresia with intact ventricular septum had type 1 or 2 right ventricle, 25 of these had early valvotomy, seven with and 18 without concomitant shunt. The remaining two patients with type 2 right ventricle and the eight patients with type 3 right ventricle received a shunt alone. Overall operative mortality was 34%; for those patients weighing more than 3 kg and those operated upon since 1977, it was 18% and 16%, respectively. There were 17 survivors of early valvotomy: 11 had valvotomy alone and six had valvotomy with shunt; 12 had type 1 right ventricle and five had type 2 right ventricle. Survival rates (+/- standard error) for these 17 patients were 85% +/- 10% and 68% +/- 17% at 5 and 10 years, respectively. The probability of reoperation was 100% by 6 years of age; outflow patch reconstruction was employed in all patients in whom reoperation has been performed. Aggressive follow-up and early recatheterization were essential features of management. Delayed reconstruction after shunt alone was unsuccessful in three patients. Primary valvotomy without shunt is the operation of choice for patients with pulmonary atresia with intact ventricular septum and type 1 right ventricle. Concomitant shunt may be required for some patients with type 1 and most with type 2 right ventricle, selected preoperatively by angiography or after valvotomy by clinical necessity. Delayed right ventricular reconstruction after shunt alone is not an acceptable approach when an outflow tract is present.

Cardiac Catheterization↗
PubMed1984

Auditory brain-stem and middle- and long-latency evoked potentials in coma.

Twenty-five patients in coma, each with a Glasgow Coma Scale measure less than or equal to five, were studied within the first three days of hospitalization with auditory brain-stem and middle- and long-latency evoked potentials. Survival was related to the simultaneous preservation of long- and middle-latency and brain-stem evoked potentials. The preservation of just middle-latency and/or brain-stem components did not correlate with survival. However, if the group of patients in coma due to head trauma was analyzed separately, survival could be related to the results of the brain-stem evoked potentials. There was no relationship between survival and the results of the initial clinical neurological examination. In patients who survived, there was no pattern of evoked potential preservation that related to the quality of survival.

Adolescent↗
PubMed1984

Enhanced late survival following coronary artery bypass graft operation for unstable versus chronic angina.

Late survival following coronary artery bypass operation is time-frame dependent, with a major improvement occurring by 1974. In the cohort of patients undergoing operation between 1974 and mid-1982, subsets were present with further enhanced survival. In this study of 3,575 patients, the urgency of clinical presentation is examined as a survival determinant, and the results are seemingly paradoxical. Among the 1,404 patients with chronic angina, survival at 1 month was 98.3%; at 5 years, 88%; and at 8 years, 79%. Among the 1,008 patients with progressive angina, survival at 1 month was 97.8%; at 5 years, 90%; and at 8 years, 80%. Among the 1,163 patients with unstable angina, 1-month survival was 98.3%; 5-year survival, 92%; and 8-year survival, 89%. The best long-term results were obtained in patients with an acute clinical presentation. Ventricular function was an important determinant of late survival for the groups with chronic (p less than 0.001) and progressive (p less than 0.001) angina, but it had no effect in the group with unstable angina (p = 0.803). For the patients with chronic angina and good left ventricular (LV) function, survival was 99.5% at 1 month; 92% at 5 years; and 86% at 8 years. For those with poor LV function, the respective survival was 96%, 84%, and 71%. For the patients with progressive angina and good LV function, 1-month survival was 98.9%; 5-year survival, 94%; and 8-year survival, 83%. For those with poor LV function, the respective figures were 96.3%, 85%, and 76%. For the patients with unstable angina and good LV function, survival at 1 month was 97.8%; at 5 years, 92%; and at 8 years, 89%.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1984

The evolution of reparative techniques for the mitral valve.

Forty-eight adult patients underwent mitral valve repair for nonischemic valvular incompetence between 1963 and 1981. Early in our experience, 21 individuals received wedge leaflet resection or leaflet plication with posteromedial commissural annuloplasty. More recently, midleaflet annuloplasty has been employed in 13 patients and is now our preferred technique. Operative mortality was 6.3%, and all deaths occurred prior to 1973. Eventually valve replacement was necessary in 10 patients; all replacements were done prior to 1977. Technical errors and progression of rheumatic disease each accounted for half of these replacements. Five-year survival by the life table method was 74 +/- 9% for the entire group. Survival at 5 years for patients with prolapsing leaflets was significantly better (87 +/- 7%) than for those with normal leaflet motion (46 +/- 14%). A residual postoperative murmur of mitral insufficiency correlated with the likelihood of subsequent valve replacement. Important technical aspects of valve repair are described, and criteria for optimal patient selection are discussed. The evolution of reparative methods has led to a better understanding and broader application of mitral valve reconstruction.

Female↗
PubMed1984

Thrombosis of mechanical cardiac valves: a qualitative comparison of the silastic ball valve and the tilting disc valve.

A review of 817 mitral and aortic Silastic ball valve implantations with a follow-up of 3,554 total patient-years yielded only seven cases of valve thrombosis. Time-related risk was 0.4% per patient-year in the mitral position and 0.1% per patient-year in the aortic position. Four of five mitral and one of two aortic ball valve thromboses were successfully managed by valve rereplacement . At least five of the seven patients presented with a prodrome (lasting at least 3 months) of symptoms of progressive heart failure and, occasionally, embolic episodes due to gradually increasing prosthetic stenosis by thrombus. This lengthy time course is in contrast to the more frequent rapid catastrophic thrombosis that occurs with the Björk-Shiley tilting disc valve. Recognition of the prodrome of Silastic ball valve thrombosis provides an opportunity for life-saving surgical intervention.

Adult↗
PubMed1984

Thrombotic and embolic complications with silastic ball prosthetic valves.

Eighteen years of continuous clinical use with the Starr-Edwards ball-valve prosthesis provides an extensive data base for comparison with more recently introduced cardiac prostheses, and establishes the credentials of this valve for current clinical use. Since 1965, 558 aortic (model 1260) and 285 mitral (model 6120) ball-valve prostheses have been inserted at the University of Oregon. Thromboembolic rates for the entire series (1965-1983) and our more recent experience (1973-1983) were 3.8% per year and 2.8% per year for the aortic valve; and 5.1% per year and 2.6% per year for the mitral valve. Patients who had experienced one embolic episode were substantially more likely to experience a subsequent event. Thrombotic stenosis was seen at rates of 0.1% per patient year and 0.4% per patient year for the aortic and mitral valves, respectively. These results are compared with other current series using a variety of mechanical and tissue prostheses. The Starr-Edwards valve remains a durable mechanical cardiac prosthesis with thromboembolic complications similar to most other current prostheses. Thrombotic stenosis tends to be rare, gradual, and electively managed as opposed to the sudden, unpredictable, and catastrophic thrombosis seen with tilting disc valves.

Actuarial Analysis↗
PubMed1984

Superior vena cava obstruction after Mustard repair of d-transposition of the great arteries.

Superior vena caval obstruction following Mustard repair of d-transposition of the great arteries is usually relieved by partial or complete revision of the intra-atrial repair. We employed a different approach in a patient with isolated total obstruction of the superior vena caval pathway, who suffered from fatigue, venous congestion in the upper part of the body and mild hydrocephalus. A 12 mm polytetrafluoroethylene tube was interposed between the left innominate vein and the left (functionally right) atrial appendage. Early and medium-term relief was demonstrated by repeat catheterization of the right heart and computed tomography brain scan three months postoperatively. The rationale for use of prosthetic material in the venous system is discussed and the need for long-term follow-up is stressed.

Blood Vessel Prosthesis↗
PubMed1984

Pericardial baffle complications following the Mustard operation. Age-related incidence and ease of management.

Pericardial baffle complications with the standard Mustard operation led first to the use of alternative materials of various shapes and finally to the recent popularity of the Senning procedure. At The Oregon Health Sciences University, we have persisted since the mid-1960s in the use of a modified Mustard operation in which a rectangular pericardial baffle is employed. Among 75 patients, there were baffle complications necessitating reoperation in 13. The reoperation-free rates (+/- standard error) at 9 years for patients less than or equal to 6 months, 7 to 12 months, and greater than 12 months of age were 59% +/- 15%, 60% +/- 17%, and 95% +/- 5%, respectively. All 10 patients reoperated upon during the past decade survived with complete relief of symptoms. A double patch to widen both the superior portion of the baffle and the superior vena cava was used most commonly and is our current procedure-of-choice. Baffle complications after the use of pericardium can be managed easily and reoperation on these patients carries a low risk. However, even with experience, the incidence of reoperation remains high in patients under 1 year of age and prompts a critical age-related comparison of these late results with the Senning procedure.

Blood Vessel Prosthesis↗
PubMed1984

Late surgical results for ischemic mitral regurgitation. Role of wall motion score and severity of regurgitation.

The indication for concomitant valve operations for ischemic mitral regurgitation is examined in 120 consecutive patients with regurgitation who had coronary bypass. Ischemic mitral regurgitation was mild in 56%, moderate in 18%, and severe in 27%. Compared with patients without mitral regurgitation who underwent coronary bypass, significantly more patients with regurgitation had cardiomegaly (31% versus 5%), left heart failure (42% versus 6%), and abnormal wall motion scores (71% versus 42%). Eighty-three patients (69%) with ischemic mitral regurgitation had coronary bypass alone and 37 (31%) also had a valve operation. All patients with mild ischemic mitral regurgitation were treated by coronary bypass alone, as compared to 67% with moderate and 6% with severe regurgitation. Operative mortalities for mild, moderate, and severe ischemic mitral regurgitation were 4%, 10%, and 38%, respectively; 5 year survival rates were 82%, 60%, and 48%, respectively. Other significant determinants of survival were wall motion score, shock, cardiomegaly, left heart failure, and acute and multiple myocardial infarctions. Patients with mild ischemic mitral regurgitation and a low wall motion score (n = 40) had a 5 year survival rate of 94%. For patients with either moderate/severe regurgitation (n = 27) or a high wall motion score (n = 25), but not both, the 5 year survival rate was 70%. In 20 patients with both a high wall motion score and moderate/severe regurgitation, it was 33%. An additive detrimental effect is apparent. The change from mild to moderate/severe ischemic mitral regurgitation was equivalent to an increase of about 8 wall motion score units in terms of effect on survival. Ischemic mitral regurgitation is a powerful additive risk factor to wall motion score in coronary bypass. Mild regurgitation is best managed by coronary bypass alone. If regurgitation is moderate, it may still be possible to avoid a valve operation and have acceptable results. Severe ischemic mitral regurgitation usually necessitates coronary bypass and a mitral valve operation.

Adult↗
PubMed1984

Combined intracardiac and extracardiac repair of scimitar syndrome with anomalous pulmonary veins to both cavae.

Anomalous pulmonary venous drainage from the right lung to the inferior vena cava (scimitar syndrome) is a rare finding. This paper briefly discusses this syndrome and presents a case of anomalous pulmonary venous return to both the superior and the inferior cavae, which was corrected with a combined extracardiac and intracardiac approach. Polytetrafluoroethylene was utilized for reconstruction of pathways to the left atrium. To our knowledge, this is the first time this technique has been used to correct this anomaly.

Adult↗
PubMed1983

Ten-year survival after coronary bypass surgery for unstable angina.

We have assessed the long-term results of coronary bypass surgery performed for unstable angina in 1282 patients from 1970 to 1982. The operative mortality was 1.8 per cent; in the first 4 years it was 2.5 per cent, and in the last 8 1/2 years it was 1.7 per cent. Using actuarial techniques, we determined that the 5-year and 10-year survival rates (mean +/- S.E.) were 92 +/- 1 per cent and 83 +/- 2 per cent, respectively, for the whole group. For patients with "normal" left ventricular function, they were 92 +/- 2 per cent and 86 +/- 3 per cent, and for patients with "abnormal" left ventricular function 91 +/- 2 per cent and 79 +/- 4 per cent (P = 0.14). No significant differences were observed in the long-term survival for any of the three clinical subgroups of patients with unstable angina--angina at rest, angina after recovery from acute myocardial infarction, and progressive angina of recent onset (P = 0.49). The reoperation rates at 5 and 10 years were 6 +/- per cent and 17 +/- 3 per cent. Currently, 61 per cent of the survivors have no angina; angina occurs on severe exertion in 20 per cent, on ordinary exertion in 14 per cent, and on mild exertion in 5 per cent. We conclude that coronary bypass surgery is an effective form of therapy (for up to 10 years) in patients with unstable angina.

Actuarial Analysis↗