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Biomedical subjects

A Soni

Publications and source records attributed to A Soni.

106 records · Page 6Linked to original sources
PubMed1981

Absorption, distribution and excretion of N-4-phenyl-phenacyl-heliotridanium bromide.

Absorption, distribution and excretion of a tritium labelled halogenomethyl-aryl-ketone derivative of pyrrolizidine alkaloid heliotridine is studied. This compound, i.e., N-4-phenylphenacyl heliotridanium bromide, a potent non-specific antispasmodic shows maximum blood level at 10 min after an i.m. injection. Half-life in blood is 1.5 h. Gastrointestinal tract (GIT) shows maximum incorporation of activity and displays main pharmacological activity. Highest concentration of drug is noticed in liver by 20 min showing a sharp fall thereafter. Excretion is mainly through urine.

Animals↗
PubMed1980

Prosopo-affective agnosia and computerized tomography findings in patients with cerebral disorders.

Thirty-nine male patients (median age 61, range 19-92) from a neurologic ward were examined by a test for prosopo-affective agnosia (PAA), i.e., impairment in the recognition of facial affect (emotions) with no impairment in the recognition of facial features (PA, prosopo-agnosia). The scores for patients without hemispheric damage were close to those of normal subjects; the scores for patients with right and left hemispheric disease were lower; and the worst performers were patients with diffuse bilateral disease. The relative independence of PAA from PA was re-affirmed. The neurologic findings on 21 patients were confirmed by computerized tomography (CT). On the PAA test, patients with negative CT results had scores close to those of normal subjects; patients with right or left hemispheric disease had lower scores; and the worst performers were patients with diffuse cortical atrophy. All patients who scored 87.5 percent or lower showed positive results with the CT scan, indicating that the PAA test may have some value in predicting positive CT findings. A significant deterioration in the ability to recognize facial affect was evident in the group of 15 patients aged 65 or older.

Adult↗
PubMed1979

Stabilized record bases for complete dentures.

A step-by-step technique has been described to construct stabilized record bases which allows the dentist to take advantage of undercuts through the use of a resilient denture liner material in the undercut regions. The resilient denture liner material protects the rugae and prevents damage to the casts in the undercut regions during repeated placing and removal from the cast. Shellac denture base material at the posterior limit of the record base permits an easy method of checking the posterior palatal seal. The incorporation of the posterior palatal seal in the record base allows for adequate retention during the recording of the maxillomandibular jaw relation records and try-in procedures. The record bases made by the sprinkle-on technique are preferred to those made using the dough method. The bases are rigid, stable, not easily broken or warped, and fit accurately.

Dental Occlusion↗
PubMedDate not supplied

Comparability of the external vs internal location of radiation in inhibiting neointimal hyperplasia.

PURPOSE: One of the most controversial issues in utilizing radiation to inhibit restenosis is the importance of the location of the radiation source. The experimental results from using external forms of radiation have been contradictory and conflicting. In this study, we undertook to externally place a brachytherapy catheter source and to determine if a dose-response effect could be observed, as has been demonstrated with endovascular locations. MATERIALS AND METHODS: Neointimal hyperplasia was created in a rat carotid artery model by a balloon catheter technique. Immediately following injury, treatment groups received irradiation via an externally located high-dose rate (HDR) 192Ir brachytherapy catheter. This system allows for a more uniform dose delivery compared with endovascular radiation sources. Radiation was delivered to a 2-cm length of the injured vessel at doses of 5, 10, or 15 Gy and the animals were sacrificed at various time points following treatment (24 h to 6 months). Serial sections of tissue were stained immunohistochemically with primary antibodies for CD11b, platelet-derived growth factor (PDGF), and alpha-smooth muscle actin. RESULTS: Radiation doses of 5, 10, and 15 Gy inhibited the appearance of neointimal hyperplasia in a dose- and time-dependent manner. That is, doses of 5-15 Gy allowed for varying degrees of neointimal hyperplasia at 3 weeks posttreatment, with a greater resurgence of monocyte/macrophage activity at 5 Gy than at 10 or 15 Gy, where an absence of macrophage activity and PDGF expression was noted. From 2 to 6 months, the 10 and 15 Gy doses were again more suppressive of neointimal hyperplasia than 5 Gy, and at 6 months posttreatment the doses were approximately 25% and 50% effective, respectively. CONCLUSIONS: The demonstrated effectiveness of external brachytherapy provides "proof of principle," that it is the radiation dose delivered to the arterial wall, and not the location of the source, which is critical to a successful outcome. Ablation of the resident monocyte/macrophage population (or prevention of their activation) occurs with low to moderate doses of irradiation, leading to the absence of a cytokine cascade as evi denced by a lack of PDGF expression. A favorable therapeutic ratio exists, therefore, for radiation treatment of the arterial vasculature to prevent neointimal hyperplasia postangioplasty.

Animals↗
PubMedDate not supplied

Clinical review: irradiation for lower extremity arterial occlusive disease.

Lower extremity atherosclerosis, a disease of aging, is both widespread and increasing in prevalence-it is estimated that almost 100,000 patients per year in the United States require operative bypass for lower extremity ischemia. It is an axiom of vascular surgery that essentially every bypass graft will eventually fail. Many if not most such failures are due to the process of intimal hyperplasia at one or both anastomoses. The search for a "cure" for intimal hyperplasia has been long, but thus far unrewarding. Recent advances in therapeutic irradiation, however, offer a potential solution to this problem. This review is designed to acquaint the radiation oncologist with the basic concepts behind lower extremity atherosclerosis and its treatment, and to introduce briefly the special problems inherent in considering irradiation of an end-to-side anastomosis.

Anastomosis, Surgical↗
PubMedDate not supplied

Dapsone hypersensitivity syndrome with coexisting acute hepatitis E.

A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.

Acute Disease↗
PubMedDate not supplied

Management of severe undercuts in fabrication of complete dentures.

The use of a RDB material has been discussed in the management of patients presenting with severe undercuts in the maxillary and mandibular edentulous jaws. In edentulous patients there are instances when a patient would feel more comfortable and hence prefer RDB material in spite of its lack of longevity. In general, dentures with resilient materials will last for about two to three years. However, in the first case discussed here, three sets of dentures have been fabricated during the last 12 years and each set lasted for four years. One reason why this patient had such success with her dentures could be her attention to good oral hygiene. Patients with RDB materials should be recalled regularly, preferably every three months, to check the condition of the RDB material and the oral mucosa. Good judgment must be used in selecting patients. Resilient denture base materials should not be used as a panacea.

Acrylic Resins↗