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Biomedical subjects

A Soler

Publications and source records attributed to A Soler.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Cytogenetic studies in fetal blood.

In order to assess the effectiveness and reliability of cytogenetic diagnosis provided by fetal blood, we report the first 186 cases of fetal blood sampling performed for rapid karyotype between 19-37 weeks of pregnancy in our Prenatal Diagnosis Unit. The overall diagnostic success rate was 98%, achieving 100% in the last period of the study. Chromosomal anomalies were detected in 16% (29/182) of the fetuses. In malformed fetuses this rate increased from 8-9% in isolated malformation or markers of aneuploidy to 50% in multiple malformations. In pregnancies in which a previous cytogenetic study in amniotic fluid was inconclusive, fetal blood made it possible to obtain a definitive result, with no discrepancies found at phenotypic follow-up examination. Interestingly enough, one of the four previously defined as pseudomosaicisms was found to be a non-mosaic in fetal blood, and only 1 of 4 mosaicisms was confirmed in fetal blood. In conclusion, cytogenetic analysis of fetal blood samples appears to be effective, rapid and reliable to establish the fetal karyotype in selected cases.

Chromosome Aberrations↗
PubMedDate not supplied

Regulation of renal Na-K-Cl cotransporter NKCC2 by humoral natriuretic factors: relevance in hypertension.

A furosemide-sensitive Na-K-Cl cotransporter (NKCC2 isoform) accounts for almost all luminal NaCl reabsorption in the thick ascending limb of Henle's loop (TALH). The activity of this transport protein is regulated by humoral factors (CIF: cotransport inhibitory factors). One family of CIF compounds is represented by the urinary phytoestrogens equol and genistein, which inhibit cotransport fluxes at similar concentrations as furosemide. Moreover, they possess similar salidiuretic potency as furosemide in the isolated perfused rat kidney, but are less potent than furosemide in vivo. Thus, dietary phytoestrogens can be responsible, at least in part, for the low blood pressure of vegetarians. A second type of CIF is represented by a circulating and urinary factor which is evoked by salt-loading. This, which is not a "ouabain-like" factor, appears to be a new retropituitary natriuretic compound. Endogenous CIF is increased in hypertensive Dahl salt-sensitive rats, probably as a compensatory mechanism against the enhanced NaCl reabsorption in the TALH, which characterizes this model of hypertension. Finally, chronic excess of circulating CIF inhibits and induces up-regulation of erythrocyte Na-K-Cl cotransporter NKCC1.

Animals↗
PubMedDate not supplied

[Differences in the subjective effects of drugs in patients with a first psychotic episode. Preliminary results].

INTRODUCTION: The study of the subjective effects of abuse substances may facilitate comprehension of the high prevalence of substance abuse in psychosis. OBJECTIVE: To assess the subjective effects of psychoactive substances in psychotic patients with substance use disorder in a prospective open study with a 6 month evaluation. METHODS: Thirty patients consecutively admitted for the first time to a psychiatric hospital because of a psychotic disorder (DSM-IV) were included. Sociodemographic data, substance use history, drug urine test, and severity of psychotic symptoms measured by BPRS, SANS and SAPS were evaluated. The subjective effects of drugs were assessed with the short form of the ARCI questionnaire. Patients were re-assessed at six months followup. RESULTS: Sixty-three percent of patients were male, mean age 29.2 years. A total of 46.6% presented at least one substance use disorder. Differences between substance users group and non-substance users group were only related to sex (more male in substance user group), and no other sociodemographic and clinical differences were found. The main abuse drugs found were: 86% cannabis, 17% cocaine, 17% alcohol, 3% heroin and 3% hypnosedatives. Fifty percent only consumed cannabis. The psychotic patients with substance use disorder showed higher punctuation in MBG scale (euphoria scale); no differences in other ARCI scales were found. At six months follow-up, 83.3% patients were re-assessed and no differences were found. CONCLUSIONS: The psychotic patients with substance use disorder showed a higher subjective effect of euphoria than non-substance user psychotics, suggesting that drug use is mainly related to obtaining euphoria-like effects than sedatives in this group.

Adult↗
PubMedDate not supplied

Pregnancies after terminal microsurgical tuboplasties with early laparoscopic control on the 8th day.

226 terminal or bipolar tuboplasties performed in a continuous series from 1976 to 1982, using microsurgical techniques, are reviewed. 5 varieties of fimbrioplasties and 5 of salpingostomies are described. As previously published, an early laparoscopy was systematically performed 8 days after the plasty, with destruction of new adhesions, the latter being a bilateral obstacle to fecundation in 10% of the total. Out of 175 primary tuboplasties, cumulative pregnancy rate (CPR) is 66% +/- 2 X 6,5 and "real" pregnancy rate (RPR) 46%. For 96 cases of hydrosalpinges, CPR is 49% +/- 2 X 7,5 and RPR 43%. The ectopic pregnancy rate is 9% and spontaneous abortion rate 8%. Out of 47 terminal iterative tuboplasties CPR is 30% +/- 2 X 9 and RPR 25%. 10% of the pregnancies are attributed to the early laparoscopy, which enabled one to destroy bilateral adhesions in these cases.

Adult↗