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Biomedical subjects

A Smith

Publications and source records attributed to A Smith.

At least 1,279 records · Page 71Linked to original sources
PubMed1980

A severely retarded 18-year-old boy with tertiary partial trisomy 14.

An 18-year-old severely mentally and physically retarded boy was found to have an unbalanced chromosome complement 47,XY, + 14q-. He had the characteristic facial dysmorphis, abnormal hands, and other features described previously in cases of partial trisomy 14, but appears to be the oldest case reported. His mother is a reciprocal translocation carrier, and lack of other carriers in the family is noteworthy.

Abnormalities, Multiple↗
PubMed1980

Insulin receptors in cystic fibrosis: increased receptor number and altered affinity.

Patients with cystic fibrosis are known to have pancreatic disorganization with associated pancreatic exocrine insufficiency. Endocrine hormonal secretion is also affected but diminution in insulin secretion is rarely accompanied by overt diabetes. We studied seven patients with cystic fibrosis to determine their carbohydrate tolerance and the status of peripheral monocyte insulin receptors. Oral glucose tolerance tests showed the presence of mild hyperglycemia and diminished insulin secretion. Mean insulin receptor sites per cell were markedly increased above controls, 25,000 vs 13,100 sites per cell while receptor affinity was diminished. The increase in receptor number could be a consequence of the insulinopenia and/or the decreased body weight of the patients and serve as a compensatory mechanism maintaining a degree of relative insulin sensitivity. Ultimate carbohydrate tolerance may be a function of the patient's ability to maintain increased receptor numbers in the face of hypoinsulinemia and impaired receptor affinity.

Adolescent↗
PubMed1980

Economic and technical considerations in the production of laboratory rodents.

Laboratory animal production costs include capital investment, operating expenses and the cost of money required to fund capital cost. Increased cost is associated with the sophistication of the building design and the degree of health monitoring required. Increasing regulations have the potential of increasing costs without improving the quality or welfare of the animals.

Animal Feed↗
PubMed1980

A pharmacokinetic and clinical evaluation of iron poly (sorbitol-gluconic acid) complex.

The pharmacokinetics of iron poly (sorbitol-gluconic acid) complex (IPSG) were studied following a single intramuscular injection of 59Fe-labelled IPSG to 4 iron deficient-patients. The results showed a more rapid uptake of iron from the site of injection than that reported with iron dextran while there was a lower urinary excretion than found with iron sorbitol citrate. A clinical study was carried out in 11 patients with iron deficiency anaemia. Patients were allocated at random to receive IPSG as either 250 mg or 500 mg elemental iron per week for 8 weeks. A satisfactory response to therapy was obtained with each regimen whether measured by an increase in haemoglobin concentration or in serum ferritin concentration. Few side-effects were encountered but discomfort and staining at the injection site was found on the higher dose schedule.

Anemia, Hypochromic↗
PubMed1980

[New technique of anatomical study of the distal autonomic nervous system of the heart in man (author's transl)].

A new technique of anatomical study of cardiac nerves in man is described, and the results of the investigation are reported and discussed. Sections of the heart, 10 micron in thickness, stained with a modification of Masson's trichrome technique, and surrounded by at least 3 nerves fibres as a marker were projected by an ordinary photographic enlarger, and drawn on a polythene foam termoplastic material. The scale drawings were cut and put together to form a scale model of the heart studied in the peripulmonary tissue and between the aorta and the pulmonary artery. The advantages and the limits of this technique are then discussed.

Autonomic Nervous System↗
PubMed1980

Stability of the calcium dioxalate complex.

The stability constant of the calcium dioxalate complex Ca(C2O4)2(2-), was measured at 38 C by examining the solubility of [45CA]whewellite in solutions with various oxalate concentrations. The solubility data showed that when oxalate was present above 10 mM increasing the oxalate concentration caused an increase in the apparent solubility of whewellite. This phenomenon was analyzed in the context of ionic equilibrium equations, and the stability constant of the dioxalate complex was estimated by fitting the experimental data with a nonlinear least-squares program. The estimated thermodynamic stability constant of the calcium dioxalate complex is 17.32 +/- 1.1 M-1.

Calcium Oxalate↗
PubMed1979

Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein.

Rat [(59)Fe]haem-(125)I-labelled haemopexin complexes (700pmol/rat) associate rapidly and exclusively with the liver after intravenous injection into anaesthetized rats. The two isotopes exhibit different patterns of accumulation. Liver (125)I-labelled haemopexin is maximum 10min after injection (20+/-4.9pmol/g of liver) and then declines by 2h to the low values (about 3pmol/g of liver) seen after injection of the apoprotein. In contrast, [(59)Fe]haem accumulates in the liver for at least 2h. Haemopexin undergoes no extensive proteolysis during 2h of haem transport as shown by precipitation with acid (98%) and specific antiserum (92%) and by electrophoresis. Moreover, only 1-2% of the dose is located in extrahepatic tissues, and there is no significant urinary excretion of either (125)I or (59)Fe. Hepatic uptake at 10min is saturable, reaching 200pmol of haemopexin/g of liver and 350pmol of haem/g of liver at a dose of 9nmol/rat, whereas uptake of the apoprotein is 3-5% of the dose. This suggests that the interaction of haem-haemopexin with the liver is a specific receptor-mediated process. The complex probably interacts via the protein moiety, since the haem analogues mesohaem and deuterohaem do not affect association of the protein with the liver but the species of haemopexin does. Increasing amounts of protein are associated with the liver 5min after injection in the order: human>rabbit>rat, and haem uptake is consistently increased. For both rat and rabbit haemopexin saturation is reached at the same concentration of protein, i.e. 180-200pmol/g of liver, indicating that the different protein species bind to a common receptor. We propose that haemopexin transports haem to the liver by a specific receptor-mediated process and then returns to the circulation.

Animals↗
PubMed1979

Surgical intervention to relieve dystocia in a python.

The surgical procedure adopted to remove non-riable eggs from the oviduct of a python, Python anchitae, is described. Recovery was satisfactory, although it was not possible to establish whether reproduction was impaired. Reasons for the type of anaesthesia used and the choice of incision made are given.

Anesthesia, General↗