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Biomedical subjects

A Smith

Publications and source records attributed to A Smith.

At least 1,135 records · Page 63Linked to original sources
PubMed1984

A comparison of attitudes toward orthodontic treatment in British and American communities.

Utilization of orthodontic services may be influenced as much by the social and cultural setting as by objective criteria. The public's assessment of dental irregularity and its perceptions of the psychosocial implications of malocclusion may be critical factors in the utilization of available services. To test these assumptions, two communities with historic differences in the availability and utilization of orthodontic services were selected as survey sites (Lexington, Kentucky, and Cardiff, Wales). Three-hundred eighty-five sixth grade children (11 to 12 years of age) and 123 of their parents were interviewed concerning dental esthetics, treatment need, and knowledge about, attitudes toward, and value placed on orthodontic treatment. Although the Lexington respondents had greater personal and indirect knowledge about such services, they did not have more positive perceptions about treatment; nor did they value straight teeth more highly. There were no significant differences between the groups' judgement of dental esthetics or assessment of treatment need. The differences in utilization of services in the two communities could not be explained in terms of differences in attitude toward malocclusion and orthodontic treatment.

Adult↗
PubMed1984

Sequence of the preprotoxin dsRNA gene of type I killer yeast: multiple processing events produce a two-component toxin.

The preprotoxin gene of the 1.9 kb M1 dsRNA genome from type I killer yeast has been sequenced employing a partial-length cDNA derived from an in vivo transcript. A single open reading frame, commencing with AUG at M1 dsRNA bases 14-16, terminates with UAG at 963-965 and codes for a 316 amino acid protein, believed to be identical to the 34 kd preprotoxin species, M1-P1, synthesized by in vitro translation of denatured M1 dsRNA. N-terminal sequencing of M1-P1 confirms this prediction. Secreted toxin is shown to consist of two dissimilar, disulfide-bonded subunits, alpha and beta, of apparent size 9.5 and 9.0 kd, respectively, whose N-terminal sequences are also found in the predicted preprotoxin sequence. Its proposed domains consist of delta, a 44 amino acid N-terminal segment, followed by alpha and beta, which are separated by gamma, a large central glycosylated segment. Processing sites, domain functions, and the potential role of gamma in immunity are discussed.

Base Sequence↗
PubMed1984

Age-based transition periods and the outcome of mental health treatment.

Do people ever get too old to change? Studies of the influence of the age of adult patients on the outcome of mental health treatment have led to inconsistent results. Design characteristics of such studies have limited our understanding of the relationship between age and outcome. Over 300 male veterans undergoing brief inpatient psychiatric treatment were categorized according to their age-based, adult developmental period (Levinson, Darrow, Klein, Levinson, & McKee, 1978). Improvement during treatment was found to be significantly related to the patient's developmental stage (r = .25, p less than .01). These results wee cross-validated and replicated using three different techniques for measuring improvement. Patients treated during transition periods, whether young or old, improved most. These results were not limited to wartime veterans. Apparently, adult males are more responsive to mental health treatment during transition periods than at other times.

Age Factors↗
PubMed1984

Atrioventricular septal defect with intact atrial and ventricular septal structures.

A heart with an atrioventricular septal defect is characterized by absence of the atrioventricular muscular and membranous septa, a common atrioventricular junction, an unwedged position of the aortic valve annulus and disproportionate inlet--outlet dimensions of the ventricular septum. The clinical and post-mortem findings are described of a case which had intact atrial and ventricular septa but had all the other anatomical hallmarks of atrioventricular septal defect. The problems in clinical diagnosis may be overcome by cross-sectional echocardiography.

Cardiomegaly↗
PubMed1984

Murine monoclonal anti-T cell antibodies for treatment of steroid-resistant acute graft-versus-host disease.

Four different murine monoclonal anti-T cell antibodies were administered to 15 patients with severe steroid resistant graft versus host disease (GVHD) in a phase I clinical trial in order to evaluate feasibility and toxicity. Antibodies 9.6 (IgG2a) and 35.1 (IgG2a) bind to separate epitopes on the E receptor (Tp50); antibody 10.2 (IgG2a) binds to the murine Lyt-1 homolog (Tp67); and antibody 12.1 (IgG2a) binds to a cell surface antigen with a molecular weight of approximately 100,000 daltons (Tp100). A total of 151 infusions were given, ranging in dose from one to 20 mg, each administered over a one to four hour period. One patient received a total of 259 mg of antibody over a period of 45 days. Six infusions (4%) in two patients were associated with fever or fever and chills. By decreasing the infusion rate, subsequent infusions to these two patients were accomplished without additional reactions. Although most of the patients treated with monoclonal antibodies required platelet support, the number of platelet units given was not significantly different from similar patients not receiving monoclonal antibodies. Six of ten patients receiving intermediate to high doses (5-20 mg) antibody therapy had evidence of at least partial improvement in GVHD in at least one involved organ system. None of the patients became immunized to mouse immunoglobulin. Our results suggest that therapy of GVHD with murine monoclonal anti-T cell antibodies is feasible and that these antibodies apparently can be administered to marrow transplant patients without significant toxicity. Further studies are required to determine which antibodies or combinations of antibodies have optimal anti-GVHD effect.

Acute Disease↗
PubMed1984

Inhibition in vitro of lipogenic enzymes from bovine (Bos taurus) mammary tissue by methylmalonyl-coenzyme A and coenzyme A.

Bovine mammary fatty acid synthetase was inhibited by approximately 50% by 40 microM methylmalonyl-CoA; this inhibition was competitive with respect to malonyl-CoA (apparent Ki = 11 microM). Similarly, 6.25 microM coenzyme A inhibited the synthetase by 35% and this inhibition was again competitive (apparent Ki = 1.7 microM). Apparent Km for malonyl-CoA was 29 microM. The short-chain dicarboxylic acids malonic, methylmalonic and ethylmalonic at high concentrations (160-320 microM) and ATP (5 mM) enhanced the synthetase activity by about 50% respectively; the activating effects of methylmalonic acid and ATP on the synthetase were additive. Methylmalonyl-CoA at 50 microM concentration inhibited the partially purified acetyl-CoA carboxylase uncompetitively by 10% and the propionyl-CoA carboxylase activity of the enzyme preparation competitively (apparent Ki = 21 microM) by 40%. Malonyl-CoA also inhibited the acetyl-CoA carboxylase activity competitively (apparent Ki = 7 microM) by 35% and the propionyl-CoA carboxylating activity of the preparation competitively (apparent Ki = 4 microM) by 82%. The possibility that methylmalonyl-CoA may be a causal factor in the aetiology of the low milk-fat syndrome in high yielding dairy cows is discussed.

Acyl Coenzyme A↗
PubMed1984

Dermatoglyphic analyses of 32 parents of Prader-Willi syndrome individuals.

Dermatoglyphic analyses were performed on 22 mothers and 10 fathers of 24 PWS individuals (32 normal relatives). The frequency of fingertip patterns in the parents was the same as in their PWS offspring with respect to a decrease in ulnar loops, and this decrease was significant when compared with controls (P greater than 0.01). It was more marked in the fathers than in the mothers. The fingertip arches and whorls were more evenly redistributed in the parents than in their PWS offspring. The TFRC of the parents showed a positive correlation with the TFRC of the PWS offspring (P less than 0.01). These data indicate heritability of the fingertip dermatoglyphics. No heritable traits were found in the palmar dermatoglyphic configurations. The fathers showed palmar anomalies greater than in control males (P less than 0.05).

Adult↗
PubMed1984

Chromosome fragility in Alzheimer's disease.

We present cytogenetic findings for 12 patients with Alzheimer's Disease (AD) mean age 75.8 +/- 6.01 years and 35 normal age and sex matched controls (mean age 74.8 +/- 4.04 years). The study, undertaken due to reports of increased fragments and chromosome breakage in individuals with AD, was performed blind on coded peripheral blood specimens and the allocation of AD or control was not known to the cytogenetic staff until the end of the study. Both the AD group and the controls have been very carefully selected and both underwent the same clinical assessment and screening procedures which included CT scanning. Chromosomes were analysed after 72 h cultures, using deprived medium TC199 which is known to enhance the appearance of fragile sites. A minimum of 50 cells was examined in each case and any rearrangement found was classified as ctg, csg , ctb , csb and the chromosome in which it occurred was recorded. Analysis of results showed that there was no statistically significant difference between the AD group and the controls for either the total occurrence of breaks, the type of aberration or the chromosome(s) involved. In both groups the commonest break was in 3p .

Aged↗
PubMed1984

Medical staff in training to become consultant physicians with an interest in diabetes.

A census in 1982 of 44 registrars and 66 senior registrars each of whom intends to become a 'consultant with an interest in diabetes' revealed that the training posts are geared to produce the 11 consultants appointments per year which currently become available. However, on top of this 'ladder' are 26 senior registrars who are already due for a consultant post. This backlog would appear to be a permanent feature unless extra new consultant posts become available. A newly appointed senior registrar can anticipate an average of 6 years before a consultant appointment. The majority of junior staff approved the current regulations and training programmes, although 87% felt that they received insufficient guidance.

Consultants↗
PubMed1984

Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs.

Colloidal suspensions of four biodegradable polymers, polylactic acid (PLA), polybutylcyanoacrylate (PBCA), gelatin (PG) and albumin (PA) were prepared within the size range 1-10 micron. In-vivo biocompatibility tests with synovial tissues were carried out to assess the irritancy of the polymers following intra-articular injection into rabbit knee joints. PLA, PBCA and PG were found to cause joint inflammation whereas PA was well tolerated by the tissues. PA microspheres may provide a means of sustaining the release and reducing the rate of clearance of drugs from the knee joint.

Albumins↗
PubMed1984

Varied light and scanning electron microscopic appearances of barium sulphate in smears and histological sections.

The various light and scanning electron microscopic appearances of barium sulphate in smears and in histopathological lesions in sections are illustrated. One type of barium sulphate (E-Z-HD) includes much larger, bright birefringent particles and has very different appearances from other widely used types. Such larger particles in sections were not originally suspected to be barium sulphate and were identified only by energy dispersive x ray analysis in a scanning electron microscope. This form of barium sulphate is used for double contrast upper gastrointestinal radiography, and is not thought to have been responsible for the lesions in which it has been observed by us.

Barium Sulfate↗
PubMed1984

Factors associated with speed of diagnosis, referral, and treatment in colorectal cancer.

Delay in the presentation of symptoms and in referral of patients for surgical opinion remains an important problem in colorectal cancer. Factors influencing patients to consult early include advice from close family or other associates and abdominal pain or vomiting, or both, as one of the early symptoms. More localised rectal symptoms and loss of weight are often associated with long delay. The "classic" symptom pictures are not often seen in the early stages of the disease. Few identifiable factors were associated with delay in referral for surgical opinion. Doctors who examine their patients (rectally or otherwise) refer them sooner. In the districts studied delay in instituting definitive treatment after consultant referral does not seem to be a major problem. There is some evidence that delay is associated with stage of the disease at presentation.

Colonic Neoplasms↗
PubMed1984

Summing up.

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Coronary Disease↗