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Biomedical subjects

A Skevas

Publications and source records attributed to A Skevas.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Macroglossia and amyloidosis. Apropos of a case].

In the present treatise, a classification scheme for macroglossia has been formulated, based on clinical and etiological features of an enlarged tongue. The pathogenesis of each form-type of macroglossia is then described. In addition to, the authors report a case of female patient suffering from macroglossia, who was admitted in their Clinic. This pathological condition was the single and the very first clinical sign (symptom) of her, and (which) led up to the diagnosis of amyloidosis. They present the procedure of the diagnosis and differential diagnosis for this patient, they emphasize their conclusions (considerations) and make comments on the coexistence or correlation of macroglossia with amyloidosis.

Aged↗
PubMed1991

[Cerebral anoxia with fatal outcome caused by aspiration of an air-filled balloon].

We report an 11-year-old child who aspirated a toy balloon causing death by asphyxia. Children who chew balloons while running and who breathe deeply or laugh at the same time are under great risk. The saliva which smears the balloon makes it easier to slide into the airway. Therefore chewing of balloons by children must be avoided because of the danger of aspiration.

Airway Obstruction↗
PubMed1990

Middle ear function in patients with juvenile chronic arthritis.

The conductive hearing of 18 patients with juvenile chronic arthritis was studied. Tympanometry was therefore undertaken for the assessment of functional state of the tympanic membrane, the ossicular chain with its ligaments and muscles, and the air cushion of the tympanic cavity. Acoustic reflex was present in all patients but an abnormal tympanometric pattern (type As) was found bilaterally or unilaterally in 10 (mostly severe cases) patients. These findings indicate that juvenile chronic arthritis changes middle ear function, probably as a result of inflammation of the synovial ossicular joints, which is followed by stiffness of the tympanic membrane and ossicular chain.

Acoustic Impedance Tests↗
PubMed1989

[An unusual lateral cervico-facial fistula].

Lateral cervical sinuses of fistula are usually derivatives of the branchial clefts and pouches and have a more or less typical course in the neck. We present a patient with an extremely long sinus extending from the left supraclavicular area, via the cheek up to the left infraorbital rim. We could not find a similar report in literature. The diagnostic evaluation as well as the successful surgical removal of the malformation through a skin incision in the neck and a second incision in the sulcus gingivobucalis are described. On the basis of a brief review in the embryology of the congenital anomalies of the neck and face some considerations about the possible origin of the cervico-facial sinuses are discussed.

Adolescent↗
PubMed1989

[Otogenic brain abscess with rupture into the lateral ventricle].

We present a case of otogenic abscess of the brain that ruptured into the ipsilateral cerebral ventricle. All the diagnostic, surgical and postoperative procedures which led not only to saving this patient but also his complete recovery are described. Because there is a great difference between rupture of a cerebral abscess into a ventricle and rupture of the ventricle into an abscess, particularly with reference to the prognosis, the pathology of the two different complications is reviewed, based on the literature.

Brain Abscess↗
PubMed1979

[Sarcoidosis of the larynx (author's transl)].

The isolated case of sarcoidosis of the larynx is very rare. We are referred to a case of histologically confirmed by the kweim-test of sarcoidosis of the false vocal cord. The problems of the case are discussed.

Female↗
PubMed1978

[Cor pulmonale due to upper airway obstruction by hypertrophied tonsils and adenoids (author's transl)].

A case of cor pulmonale is reported, due to chronic nasopharyngeal obstruction by hypertrophied tonsils and adenoids. This syndrome is characterized by stridor, somnolence, arterial hypoxia and hypercarbia, pulmonary and right heart failure. The pathogenesis of this syndrome is due to pulmonary hypoventilation. After tonsillectomy and adenoidectomy the symptoms disappeared.

Adenoids↗
PubMed1977

[Vagus neurinoma of the basic of the skull and endocranium (author's transl)].

We are discussing a case of neurinoma of the tenth cranial nerve in the area of the base of the skull with endocranial extension in a 51-years-old female patients. The first symptom was hoarseness of the voice, and three years later more cranialnerves were involved (V-VII-X-XI-XII). The existence and the extension of the tumor was verified by radiological examination of the base of the skull, carotic angiography, myelography and scanning; the diagnosis was proved by biopsy. The treatment of choice is the operation because the tumor is radioresistant.

Cranial Nerve Neoplasms↗
PubMedDate not supplied

Prelingual nonsyndromic hearing loss in Greece. Molecular and clinical findings.

Mutations in the gene encoding the gap-junction protein connexin 26 (GJB2) on chromosome 13q11 have been shown as a major contributor to prelingual, sensorineural, nonsyndromic deafness. One specific mutation, 35delG, has accounted for the majority of the mutations detected in the GJB2 gene in Caucasian populations and is one of the most frequent disease mutations identified so far with highest carrier frequency of 3,5% in the Greek population. In a collaboration with the major referral centers for childhood deafness in Greece, patients were examined by an extensive questionnaire to exclude syndromic forms and environmental causes of deafness and by allele-specific PCR for the detection of the 35delG mutation. The 35delG mutation was found in 32.1% of the alleles in 173 unrelated cases of prelingual deafness: 50 homozygotes and 11 heterozygotes. Individuals heterozygous for the 35delG mutation were further analyzed by direct genomic sequencing of the coding region of the GJB2 gene, which revealed R184P and 486insT mutations in single alleles. We conclude that the 35delG GJB2 mutation is responsible for one third of prelingual, sensorineural deafness in Greece, which is higher than the usually quoted 20% for Caucasian populations.

Audiometry, Pure-Tone↗
PubMedDate not supplied

Altered patterns of retinoblastoma gene product expression in benign, premalignant and malignant epithelium of the larynx: an immunohistochemical study including correlation with p53, bcl-2 and proliferating indices.

In order to study the altered Rb, bcl-2 and p53 proteins expression during laryngeal carcinogenesis and to elucidate the role of these molecules in the development and progression of the lesions, we have examined the immunohistochemical expression of these markers in a series of 41 squamous cell carcinomas, 14 cases of in situ carcinoma, 47 with epithelial dysplasia, 11 papillomas and 20 cases of keratosis. Rb protein was expressed in 69.7% (> 5% positive neoplastic cells) of squamous cell carcinomas and p53 in 40% (> 5% positive cells). There was a strong statistically significant difference for Rb, Ki-67 and PCNA immunostaining between malignant, premalignant and benign lesions, increasing from keratosis, papillomas, dysplasia to carcinoma in situ or infiltrating squamous Ca. Rb protein expression was also strongly correlated with p53, Ki-67 and PCNA, while p53 protein was strongly correlated with Ki-67 (p = 0023) and PCNA (p = 0.0031) indices, in all lesions. In conclusion Rb and p53 altered proteins expression seems to play an active role in laryngeal carcinogenesis, probably from the early phase, and is correlated with proliferative activity. Also, Rb protein expression is correlated with the progression of the lesion and could be considered as indication of poor prognosis in laryngeal lesions.

Adult↗
PubMedDate not supplied

Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.

Clinical studies in several tumour types have shown a strong correlation between cathepsin D expression and tumour progression. Immunohistochemical staining for cathepsin D (clone D13A) was performed in paraffin embedded-tissues from 39 invasive squamous cell carcinomas, 13 in situ carcinomas, 35 cases of dysplasia, 10 papillomas and 17 cases of keratosis. The association between cathepsin D expression and CD44, p53, Rb proteins and proliferation indices (Ki-67, PCNA) was assessed by univariate analysis. Cathepsin D was highly positive in the groups of carcinomas compared to other lesions (p < 0.0001). A statistically significant correlation of cathepsin D expression with CD44 expression was observed in invasive cancers (p = 0.037). The relationship of cathepsin D immunoreactivity with p53, Rb and proliferation indices was insignificant. The results show that cathepsin D is expressed in a higher proportion of cancerous lesions of the larynx than in non cancerous or premalignant lesions, a fact which suggests that cathepsin D may be involved in laryngeal tumour cell growth process.

Carcinoma in Situ↗
PubMedDate not supplied

Oral focal epithelial hyperplasia.

Focal epithelial hyperplasia (FEH) or Heck disease, is a rare viral infection of the oral mucosa caused by HPV 13 or HPV 32. In Caucasians there have been only a few cases reported. We present the first case in Greece in a young Caucasian girl in which HPV 13 was detected with PCR analysis. The patient was successfully treated with CO2 laser.

Adolescent↗
PubMedDate not supplied

Prognostic significance of p53 in the cancer of the larynx.

p53 is a nuclear phosphoprotein acting as a transcription factor to regulate cell cycle progression and apoptosis, mediated by a number of target genes. p53 mutant proteins have lost a) the ability to act as sequence-specific transcription factors and b) their tumour suppressive properties. As p53 is the most commonly mutated gene in human cancer, including laryngeal squamous cell carcinoma, an aggressive and most frequent tumour of head and neck, it has attracted a great deal of interest as a prognostic factor, diagnostic tool and therapeutic target. This article reviews the current understanding of the prognostic significance of p53 in laryngeal squamous cell carcinoma. Immunohistochemical staining techniques and molecular genetics demonstrated that p53 activation is an early event in laryngeal squamous cell carcinogenesis but can not be used as a reliable prognostic marker.

Genes, p53↗