Biomedical subjects
A Singh
Publications and source records attributed to A Singh.
Histology of the caprine hemal node.
Caprine hemal nodes were studied by light microscopy after glutaraldehyde fixation and epoxy resin embedding. A node consisted of a capsule, subcapsular and other sinuses, cortex, medulla and hilus. Elements of circulating blood filled the interstices of the reticular meshwork and associated macrophages which traversed the lumina of subcapsular and medullary sinuses. The latter were rare in 1-month-old goats, progressively increased in number and size in 2- to 4-month-old goats and coalesced with each other and the subcapsular sinus in adult animals. The cortical tissue appeared as lymphoid nodules. Circumferential lymphatic vessels abutted on outer margins of the nodules and gave origin to several radial lymphatics which branched and anastomosed between the medullary blood sinuses. Medullary cords were organized around the radial lymphatics. A single efferent lymphatic was formed at the hilum by confluence of the radial lymphatics. Our study, in contrast to earlier reports, shows that caprine hemal nodes possess efferent lymphatics. The present data suggest that the hemal nodes are involved, in addition to classical functions, in blood storage by hemoconcentration.
The fears expressed by elderly men and women: a lifespan approach.
This article reports one of the first studies of adult fears, specifically in an elderly population. Results indicated that older women expressed greater fearfulness than older men, a sex differential also observed in children and adolescents. When compared to other adult groups, significant differences were noted on several categories of fears. The elderly group ranked aging and sickness as their foremost fears, although the absolute degree of fearfulness did not differ from the comparison groups. Considered with previous investigations, these results suggest that some fears may change or intensify over the lifespan, and that within each period females report greater fearfulness than males. Additionally, this article describes a new entity, "fisity," which accounts for the popularity and the intensity of fears in a single measure.
Effects of vitreous from photocoagulated eyes on retinal microvascular cells in culture: a preliminary report.
Panretinal photocoagulation was carried out in mini pigs in an attempt to elucidate the mechanisms involved in laser therapy. The effect of the vitreous from these eyes on the proliferation of retinal microvascular endothelial cells was then studied. Vitreous removed 4 days after panretinal photocoagulation had no effect on the proliferation of bovine retinal microvascular endothelial cells in basal medium but inhibited proliferation in growth medium. Control vitreous was mitogenic for the microvascular cells in basal medium but this effect was not observed in growth medium.
Severe post burn flexion contracture of hand--a single stage method of management.
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Extrachromosomal control of antibiotic resistance, DNase activity and enterotoxin production in Streptococcus faecalis.
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Fabrication of key components of a receptor-based biosensor.
A three-pronged approach was taken to the development of receptor-based bisensors. First, asymmetric bilayer membranes were developed with one monolayer adaptable to the particular receptor of interest and the other monolayer polymerized to enhance membrane stability. Second, alamethicin and calcium channel complexes were introduced into the stabilized membrane and tested for ion-channel function. Third, a porous support for the receptor-containing membrane was fabricated, which is compatible with silicon technology. Preliminary devices incorporating these components were constructed.
Analysis of electrophoretypes of rotavirus from diarrhoeic faeces of neonatal buffalo calves in India.
Two distinct rotavirus RNA electrophoretypes were revealed by polyacrylamide gel electrophoresis followed by silver staining (PAGE-SS). The rotavirus was sampled from the faeces of buffalo calves in India from October, 1986 to January, 1987. In the buffalo farm under study one electrophoretype was prevalent first and then the second appeared after the disappearance of the first electrophoretype. For the detection of rotavirus in the diarrhoeic faeces of buffalo calves PAGE-SS was found more sensitive when compared with agar gel immunodiffusion and discontinuous counter immunoelectrophoresis tests.
Success and complication rates of coronary angioplasty in patients with and without previous myocardial infarction.
The primary success rate and incidence of major complications have been retrospectively assessed in a consecutive series of 224 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) in one centre. The patients have been divided into three groups; those with angina and no previous myocardial infarction (Group 1; N = 130), those with angina and a previous transmural myocardial infarction (TMI) (Group 2; N = 59), and those with angina and a previous non-transmural myocardial infarction (NTMI) (Group 3; N = 26). The three groups were well matched for age, gender and angiographic severity of stenosis. The primary success rate in Group 1 was 90% compared to 64% in Group 2. The success rate in Group 3 lay in between at 77%. The lower success rates in Groups 2 and 3 were mainly due to an increase in the frequency of major complications. Acute coronary occlusion occurred in seven patients in Group 1, nine patients in Group 2 and four patients in Group 3. In all these patients in Groups 2 and 3 the outcome of acute occlusion was a procedure-related clinical myocardial infarction despite immediate re-angioplasty and/or emergency coronary artery bypass grafting whereas only four patients in Group 1 sustained an acute infarct. In this series of patients undergoing coronary angioplasty for symptom limiting angina, previous myocardial infarction appears to be a risk factor for a lower success rate mainly due to an increase in the frequency and severity of major complications.
Esophageal pressure monitoring: a practical adjuvant to hemodynamic monitoring with positive end-expiratory pressure.
With positive end-expiratory pressure (PEEP)-induced reduction in cardiac output, measurement of ventricular filling pressure assists in proper therapeutic decision-making. Because PEEP may increase pleural and juxtacardiac pressure, central venous pressure (CVP) and left atrial pressure (LAP) measurements during PEEP may not simply reflect ventricular filling, but rather reflect the sum of intracardiac and extracardiac forces. Monitoring devices placed within the central circulation use saline solution-filled lumens and transducer systems for pressure monitoring. Therefore, any device designed to estimate the extracardiac influence of PEEP on intraluminal monitoring devices would be expected to reflect such changes best when the device is also filled with saline solution. In the present study, esophageal pressure (Pes) was measured with a saline solution-filled balloon-equipped nasogastric tube to estimate the extracardiac influence of PEEP on CVP and LAP. Pes, CVP, LAP, and cardiac index (CI) were measured in 17 patients subjected to 0, 5, 10, 15, 20 cm H2O PEEP. Comparing 0 with 20 cm H2O PEEP, CVP (7 +/- 1.0 mm Hg to 13.4 +/- 1.3 mm Hg), LAP (6.3 +/- 1.1 mm Hg to 11.7 +/- 1.4 mm Hg), and Pes (6.1 +/- 1.4 mm Hg to 12.1 +/- 1.5 mm Hg) all increased significantly as CI fell (2.72 +/- 0.14 L/min/m2 to 2.20 +/- 0.15 L/min/m2).(ABSTRACT TRUNCATED AT 250 WORDS)
Severe acute mountain sickness (AMS) in a permanent resident of Shimla.
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Behaviour of expression of nif HDK and fix ABCX promoters of Rhizobium meliloti in R. leguminosarum.
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Legal tests for diagnosis and treatment.
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Nutritional status of land-based U.S. Navy divers.
The nutritional status of 16 male, land-based U.S. Navy divers was assessed to collect baseline information for a cold water dive series. Diet records, blood samples, and 24-h urine collections were obtained and analyzed. The divers were deriving 17 +/- 1%, 40 +/- 2%, 32 +/- 2% of their calories from protein, carbohydrate, and fat, respectively. The remaining calories were furnished by alcohol (11 +/- 2%), an amount within the American Heart Association's guidelines. Crude fiber intake was low (3.7 +/- 0.4 g/d) whereas cholesterol (507 +/- 101 mg/d) and sodium intakes (4462 +/- 599 mg/d) were high. Mean intakes of vitamin B6 and folacin were below the Military Recommended Dietary Allowances. Mean blood concentrations and urinary excretion of minerals were normal but urinary sodium excretion was high. Results indicate that the divers' intakes of sodium and cholesterol were high, whereas intakes of complex carbohydrate and crude fiber were low. Whether these dietary patterns are suitable for extended dives, especially in cold water, remains to be determined.
Effect of exposure to toxic gas on the population of Bhopal: Part III--Assessment of toxic manifestations in humans--haematological and biochemical studies.
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Wound healing: some observations.
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Localization and correlation effects in itinerant ferromagnets.
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Metacarpophalangeal arthropathy associated with manual labor (Missouri metacarpal syndrome). Clinical radiographic, and pathologic characteristics of an unusual degeneration process.
We describe 7 manual laborers with painful, palpably enlarged metacarpophalangeal joints. Characteristic radiographic changes were joint space loss, prominent osteophytes, and cystic metacarpal heads most prominent in the second and third metacarpophalangeal joints. In 3 of 4 patients, joint biopsy specimens showed subsynovial fibrosis and villous hyperplasia. All 7 patients had similar backgrounds of heavy work demanding sustained gripping motions of both hands, for periods that exceeded 30 years. We designated their condition metacarpophalangeal arthropathy associated with manual labor.