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Biomedical subjects

A Simon

Publications and source records attributed to A Simon.

At least 487 records · Page 27Linked to original sources
PubMed1979

An evaluation of iridology.

Iridology is an analysis of health based on examination of the iris of the eye. One hundred forty-three patients had photographs taken of both eyes. Nine-five patients were free of kidney disease, defined as a creatinine level of less than 1.2 mg/dL (mean, 0.8 mg/dL), and 48 had kidney disease severe enough to raise the plasma creatinine level to 1.5 mg/dL or greater (mean, 6.5 mg/dL). Three ophthalmologists and three iridologists viewed the slides in a randomized sequence without knowledge of the number of patients in the two categories or any information about patient history. Iridology had no clinical or statistically significant ability to detect the presence of kidney disease. Iridology was neither selective nor specific, and the likelihood of correct detection was statistically no better than chance.

Adult↗
PubMed1979

[Phaeochromocytoma: localisation by computerised scanner tomography. 5 cases (author's transl)].

In five patients with a phaeochromocytoma, axial computerised scanner tomography made it possible to localise the tumour without ambiguity, even when intravenous urography had been interpreted as normal. Although all the tumours diagnosed were relatively large (between 3 and 9 cm), this is nevertheless a non-invasive examination, free of danger and worthy of consideration in the preoperative assessment of a case of phaeochromocytoma.

Adrenal Gland Neoplasms↗
PubMed1979

[Electrocardiographic evolution of severe medically treated hypertension].

Electrocardiographic finding were studied in 34 severe hypertensions submitted to antihypertensive therapy. The duration of the survey was between 2 and 6 years. No significant correlation was observed between the changes in pressure and the changes in electrocardiogramm: normalisation of blood pressure could be associated with abnormalities in the electrocardiogramm, concerning especially ST segments and T waves. In the latter case, a high frequency of coronary insufficiency was observed. The results suggested that cardiac factors, independent of the pressure level, could determine the electrocardiographic changes during antihypertensive therapy.

Adult↗
PubMed1978

[Essential hypertension: long term haemodynamic effects of a diuretic combination (cyclothiazide-triamterene) (author's transl)].

The long terme hemodynamic effect of cyclothiazide 3 mg-triamterene 150 mg was studied in 10 patients with permanent essential hypertension. Diuretic therapy induced a significant fall in blood pressure (p less than 0.001) and total peripheral resistance (p less than 0.01), without significant change in cardiac index or blood volume. The result suggests that adaptative mechanisms of the circulatory system determine the decrease of blood pressure, independently of the pharmacological effect of the drug.

Adult↗
PubMed1978

(+)-Propranolol clearance, an estimation of hepatic blood flow in man.

1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged during (+)-propranolol administration. 3 Hepatic extraction ratio was 74 +/- 1% (+/-)-propranolol and 79 +/- 2% for (+)-propranolol. 4 Total propranolol clearances were determined during the steady-state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)-propranolol clearance. The slope of the curve was 1.05 +/- 0.27. 5 The result implies that the total clearance of (+)-propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function.

Adult↗
PubMed1978

[Evaluation of cardiac performance in the hypertensive patient. Effect of a beta-blocking agent: atenolol].

Cardiac output (isotopic dilution method) and systolic time intervals were studied in 11 sustained and 8 borderline essential hypertensive patients, before and after intravenous administration of atenolol, a potent beta-blocking agent. Atenolol decreased significantly (p less than 0.01) cardiac output and heart rate. In borderline hypertensives, the preejection periods were significantly reduced. Atenolol prolonged the preejection periods more significantly (p less than 0.01) in borderline than in permanent hypertensives. Non invasive hemodynamic technics enabled the cardiac performance to be evaluated in hypertensives and the contribution of neurogenic factors in borderline hypertension to be estimated.

Atenolol↗
PubMed1977

[The sympathetic nervous system inhibition in the antihypertensive effect of beta-blockers (author's transl)].

The decrease of sympathetic activity by the beta-blocking drug, as demonstrated by the decreased electric activity of the splanchnic nerve and by the decreased urinary catecholamine reponse to tilt as well as by the decreased levels of plasma dopamine beta-hydroxylase exists not only in hypertension with elevated PRA but also in hypertension with normal or low PRA. In these latter cases the antihypertensive effect is better explained by the decrease in the sympathetic nervous system activity than by the decrease of PRA. This effect seems to be indirect and probably, as suggested by Lewis, as a result of damping sensory input to the central nervous system from the heart, whose capacity to respond to exercice and stress is blunted by beta-adreno-receptor blockade.

Adrenergic beta-Antagonists↗
PubMed1977

[Systemic arterial hypertension: pathogentic role of the sympathetic nervous system].

Role of the clinical and experimental data suggesting the role of the sympathetic nervous system in some essential hypertension are reviewed: increase in heart rate and diastolic blood pressure during orthostatism, increase in cardiac output resulting from increase in cardiopulmonary blood volume and/or in myocardial contractility, increase in peripheral resistances, elevated plasma catecholamines and dopamine-bêta-hydroxylase, disturbances in arterial baroreceptor sensitivity and in vascular response to adrenergic stimuli, elevated plasma renin activity. It appears that the role of a sympathetic overactivity is mainly important in labile hypertension with hyperkinetic syndrome and elevated plasma renin activity.

Animals↗
PubMed1977

Influence of age, ability, and angle on pupils' judgments of size of angles.

80 subjects of 11 to 14 years were tested with 8 cards on which were printed angles between 0 degrees and 180 degrees, and on the Raven's Progressive Matrices Test and the Schonell R4 Reading Test. Significant differences on performance were found in relation to age and ability variables and as between angle sizes 0 degrees--90 degrees and 90 degrees--180 degrees.

Adolescent↗
PubMed1977

Differential staining of calcified tissues in plastic embedded microtome sections by a modification of Movat's pentachrome stain.

Movat's pentachrome I stain has been adapted and modified as a stain for undecalcified bone sections. After embedding in methyl methacrylate, this procedure yields consistently good results, with an excellent and colorful contrast between mineralized and unmineralized compartments of both cartilage and bone. In addition, osteoblasts, osteoclasts, and other cells and tissue components can easily be differentiated. The staining properties of the lacunar wall surrounding the osteocytes are considered to reflect various states of osteocytic activity. The method is especially useful for the study of bone growth and bone repair, and as a stain for conventional histomorphometry and computer-assisted image analysis in bone biopsies.

Animals↗
PubMed1976

Comparison of the pharmacokinetics of intravenous dl-propranolol in borderline and permanent hypertension.

In borderline and permanent hypertensives after rapid i.v. injection of dl-propranolol 0.2 mg/kg plasma levels were measured and were fitted to a two-compartment open-model. In borderline patients, characterized by a high basal cardiac output (CO), plasma levels were always lower than in permanent hypertensives. The biological half-life was reduced and the central volume of distribution, volume of distribution at pseudo-equilibrium and total clearance (TC) were markedly increased. In the overall population, there was a significant positive correlation between CO and TC. Rapid achievement of a predetermined plateau in each group constituted experimental proof of the validity of the two-compartment open-model for kinetic analysis of propranolol i.v. If kinetic parameters from permanent hypertensive were applied to borderline hypertensives a lower plateau was obtained. Thus, in so far as beta-blockade is related to plasma level of propranolol, an increased intravenous dose may be required in patients with high CO.

Cardiac Output↗
PubMed1976

[Labile arterial hypertension and sympathetic tonus. Hemodynamic study].

Cardiac output, cardiopulmonary (CPBV) and total (TBV) blood volumes, vascular reactivity to norepinephrine and dopamine B hydroxylase (DBH) were determined in 41 borderline hypertensives patients in comparison with 28 normal subjects. Cardiac output (P less than 0.001) and CPBV/TBV ratio (P less than 0.01) were significantly increased. The ratio was directly correlated to the pressor-response to norepinephrine (P less than 0.01) and the DBH level (P less than 0.005). The results suggest that sympathetic overactivity plays a dominant role in the cardiac output elevation of borderline hypertensive patients.

Adult↗