Biomedical subjects

A Sicard

Publications and source records attributed to A Sicard.

At least 19 recordsLinked to original sources

PubMed2006

ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance.

OBJECTIVE: Inflammation in adipose tissue may link obesity to insulin resistance and atherosclerosis. Arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene is involved in the pathogenesis of atherosclerotic cardiovascular disease (CVD). We investigated ALOX5AP expression in adipose tissue, and association of gene polymorphisms with obesity and insulin resistance. DESIGN: For gene expression analysis in adipose tissue, we studied 12 lean and 36 obese women, eight lean and 13 obese men, and nine women before and 2-4 years after gastric banding surgery. For genetic analysis, we studied 231 nonobese and 350 obese men. RESULTS: The ALOX5AP protein, 5-lipoxygenase activating protein (FLAP), as well as 5-lipoxygenase (5LO) itself, were detected in adipocytes. The mRNA expression of ALOX5AP in subcutaneous adipose tissue was increased in obesity and normalized following weight reduction. High adipose tissue mRNA expression of ALOX5AP is associated with insulin resistance as measured by homeostasis model assessment (HOMA(IR)). ALOX5AP haplotypes that associate with CVD are not associated with obesity or insulin resistance. CONCLUSION: ALOX5AP is present in adipose tissue, where its expression is associated with body weight and HOMA(IR), and may provide a link between adipose tissue, inflammation and insulin resistance. Investigated ALOX5AP haplotypes are not major primary risk factors for obesity and insulin resistance.

5-Lipoxygenase-Activating Proteins↗

PubMed1998

[The origins of the National Academy of Surgery].

The French Academy of Surgery was not created easily largely due to the frequent quarrels between physician and surgeons. Founded in 1731, it experiented many trials and tribulations for three centuries. Disbanded in 1793 by the Convention, it was transformed into Société Nationale in 1843 and only regained the name of Académie in 1935.

Academies and Institutes↗

PubMed1996

[Information on the Federation of national academies of medicine of the European Union].

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Academies and Institutes↗

PubMed1996

[Introduction of cervico-vaginal smears in France].

Cervico-vaginal smears were quite difficult to accept when they were first introduced in France, during the fifties, probably due to a fear that cytology might replace surgical pathology, whereas both methods may develop close together. At last, bridging the gap was accomplished by the pathologists and, nowadays, a number of cytopathologists have been trained and have become quite clever. Obviously, clinicians cannot do without the method described by George N. Papanicolaou (the so-called Pap test). Although cervical carcinoma is the very one cancer that should have been eradicated, as complete recovery is the rule when the diagnosis is made in time, at the preinvasive stage of the tumor, in France it is still responsible for 2000 annual deaths. Systematical target population screening should be organized, as well as in other countries and should become one of the main priorities of health care control.

Female↗

PubMed1995

[The transfer of Baron Larrey's ashes from the Père Lachaise cemetery to the Invalides (December 14-15, 1992)].

In its meeting of May 20, 1990, the Société française d'Histoire de la Médecine decided to support Baron Larrey's wish to be buried in the Invalides. Owing to its initiative and efforts this wish is presently fulfilled. The transfer of Baron Larrey's ashes was realized on December 14 and 15, 1992. The authors report this historical event.

Burial↗

PubMed1994

[A eulogy for doctor André Pecker 1902-1994].

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France↗

PubMed1994

[French surgery in the eighteenth century].

The history of surgery in France begins practically during the 18th century which has been with the 20th century the period which has the more contributed to its progress. The 18th century during which have been practiced the first surgical operations has been inceasingly characterized by the dissensions between physicians and surgeons till the creation under the reign of Louis XV of a Royal Academy of Surgery of which the realizations have joined together all the surgical acquisitions of the century.

France↗

PubMed1994

[The road accident is not inevitable].

Doctors can play an essential role in the epidemiology of road accidents. Problems of vision are important and require new legislation as a result of recent studies. Fatigue, drowsiness and falling asleep among driver is recognized in approximately 30% of cases. Better information should take into account recent surveys underlining the frequency of this problem. The taking of licit or illicit drugs is a non-negligible factor in the loss of control of a vehicle during prolonged journeys, and is particularly aggravated by alcohol. Users, of whom there are many in France according to statistics, should be better informed about the risks, both by clear warnings on containers and by the prescribing doctors. Of all causes of accidents, those that are about to be discussed are among the most frequent. Their prevention should diminish road mortality, a veritable national scourge.

Accidents, Traffic↗

PubMed1994