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Biomedical subjects

A Shohtsu

Publications and source records attributed to A Shohtsu.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Experimental and clinical study of interactions between fluorinated pyrimidine derivatives and anticoagulants].

Interactions between fluorinated Pyrimidine derivatives and anticoagulants were studied experimentally and clinically, using transplanted tumor tissues of Donryu rats and tissues from lung cancer patients. In rats, which were given 5-FU, uracil, tegafur and UFT respectively, the higher tumor concentrations of 5-FU and uracil were observed when given warfarin and ticlopidine beforehand, on the other hand, the concentrations of tegafur were almost the same between rats with and without anticoagulants. In patients with lung cancer, who were given UFT and anticoagulants, the higher concentrations of 5-FU and uracil in plasma, tumor and lymph nodes were observed than those who were given UFT alone. The 5-FU concentrations in normal lung tissues were about a half of those in tumor. These results suggest a existence of the synergistic effects between fluorinated pyrimidine derivatives and anticoagulants in plasma and tissue concentrations of 5-FU.

Animals↗
PubMed1988

[Clinical results of UFT plus anticoagulants as a postoperative adjuvant in lung cancer patients].

Warfarin, Ticlopidine and UFT as postoperative adjuvant have been administered patients with stage III and IV lung cancer who underwent surgical resection. In a controlled trial, 55 patients were divided into two groups, one with anticoagulants and UFT (27 cases), the other with UFT alone (28 cases). The prognoses of the two groups were followed for 6 years. The anticoagulant group demonstrated a statistically greater interval from operation to recurrence the control group, although the recurrence rates and the interval from recurrence to death were almost the same between the two groups. Survival rates of anticoagulant group were always superior to those of control group after 12 months postoperatively, and the median survival was about twice that of the control group. Although survival rates between the two groups revealed no statistical difference, in patients with adenocarcinoma, the difference between the two groups was statistically significant.

Anticoagulants↗
PubMed1988

[Early detection of central nervous system dysfunction during cardiopulmonary bypass using EEG monitoring].

The EEG was monitored in fifty-four patients during and after various surgeries requiring cardiopulmonary bypass (CPB) to assist in the early detection of central nervous system dysfunction (CNSD). Bilateral frontopolar EEG signals were processed with a 2-channel, real-time Fast-Fourier-Transformer (FFT) analyser and Compressed Spectral Arrays (CSA) were obtained. The fifty-four patients were divided into 3 groups based upon clinical outcome; Group 1: patients without CNSD (83%); Group 2: patients with delayed recovery from anesthesia but without CNSD (4%); and Group 3: patients with apparent postoperative CNSD (13%). There was no difference in the CSA among these groups prior to rewarming, but after the rewarming phase, two distinct sets emerged. Groups 1 and 2 showed a shift of the CSA predominant peak from a low frequency to a higher frequency. On the other hand, Group 3 patients demonstrated either stable predominant peaks in the lower frequencies or gradual flattening of the CSA. We conclude that the intra-operative EEG monitoring is a useful tool for the early detection of CNSD during and after CPB.

Adult↗
PubMed1987

Relation of ABH blood group antigen expression to prognosis in lung carcinoma.

The ABH blood group antigens were studied in resected specimens from patients with lung cancer employing monoclonal antibodies against A, B and H antigens by the immunoperoxidase technique. There were no differences between paraffin-processed and fresh-frozen materials in detectability of ABH antigens. Comparing specimens at operation with those at autopsy from the same patient, the loss of A and B antigens in the latter was demonstrated more frequently than H antigen. Concerning the relation between the prognoses and the expression of ABH antigens, the group with good prognosis preserved more ABH antigens than that with poor prognosis. In contrast, the group with poor prognosis showed less ABH antigens. There were also statistical differences in antigen detectability and prognosis, particularly in stage 1 patients, adenocarcinomas and well-differentiated lung cancers.

ABO Blood-Group System↗
PubMed1986

[Abnormalities of blood coagulation and effect of anticoagulant therapy in postoperative patients with lung cancer].

To evaluate coagulable state, beta-thromboglobulin (beta-TG) levels have been followed sequentially in 70 postoperative patients with lung cancer. Nineteen out of them were treated with warfarin plus ticlopidine at a dosage enough to prolong the thrombo-test time to approximately 20% of normal value. There was a significant rise in beta-TG compared with control subjects and beta-TG was correlated with stages of disease. Serial beta-TG determinations revealed that beta-TG and CEA levels fairly paralleled with each other which suggested beta-TG might be useful in following tumor progression or response to therapy in postoperative period. As to the relation between beta-TG levels and five-year survivals, patients whose beta-TG were under 50 ng/ml showed more favorable prognoses than those who had higher levels. Long term anticoagulation with warfarin plus ticlopidine reduced the beta-TG levels of 19 stage 3 or 4 patients, especially in stage 4 the rate of reduction was marked. Nineteen patients with anticoagulant-treated group demonstrated a more prolonged time from beginning of treatment to first evidence of disease progression than 18 non-treated patients. Also anticoagulant-treated group had a more prolonged clinical course than non-treated group after disease progression. These results might be associated with disease stabilization which achieved with anticoagulant therapy. Survival at 30 months after initiation of treatment was 74% in the treated group and 64% in the nontreated group. Although there was no statistical difference in two groups, survival of treated group exceeded that of the non-treated group throughout the observation period. In stage 4 patients, however, the difference between two groups was statistically significant.

Adult↗
PubMed1986

Surgical results for the treatment of primary carcinoma of the lung.

In order to examine the effectiveness of surgical therapy for primary lung carcinoma, 200 surgical patients were reviewed. Survival rates were compared to the initial operative approach, the tumor stage, and the histological type. The five year survival rate was 62% for Stage 1 tumors, 60% for Stage 2, 21% for Stage 3 and 32% for Stage 3 when metastases were confined to the ipsilateral hilar lymph nodes. The most profound influence on prognosis was exerted by the presence or absence of metastases to the mediastinal lymph nodes. Other factors such as tumor size, histological type, and degree of differentiation did not appear to affect prognosis. With extended resections of the adjoining organs, a 5 year survival rate of 37% was obtained in patients in whom the carcinomatous infiltration did not extend beyond the boundaries of the aortic adventitia, pleura, or pericardium. However, it was 0% when this boundary was broken. The CT scan was found to be helpful in the preoperative identification of carcinomatous infiltration. In some patients with preoperative CT scans demonstrating limited infiltration, the left atrium or aorta was resected and satisfactory long term survival was obtained. Finally we examined the effectiveness of the addition of radical lymphadenectomy of the right mediastinal nodes during the treatment of left lung carcinoma. This was performed by adding a median sternotomy to the standard left thoractomy and was well tolerated.

Adenocarcinoma↗
PubMed1984

Endotracheal tube with movable blocker to prevent aspiration of intratracheal bleeding.

A newly developed endotracheal tube with a movable blocker was found to be lifesaving in patients with copious and persistent intratracheal bleeding. The cases of 4 patients are presented. In 3 patients, severe intratracheal bleeding was attributed to the extensive bronchopulmonary laceration caused by blunt chest trauma. In the remaining patient, the bleeding was due to rupture of the sutured site in the right pulmonary artery; the rupture was caused by a postoperative bronchopleural fistula. In these patients, spread of blood was completely prevented and pulmonary resection was performed safely by using the blocker in this new device.

Adult↗