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Biomedical subjects

A Shepherd

Publications and source records attributed to A Shepherd.

32 records · Page 2Linked to original sources
PubMed1980

Acute duodenal ulceration in children.

Seven cases of acute duodenal ulcer in Papua New Guinea children have been treated personally over a period of 14 years. All had bled, six seriously enough to threaten life, while in five cases laparotomy revealed unsuspected perforation. Aspirin and antimalarials may have been causal in two children. In three others there was an associated illness, but no common cause could be found to explain all cases. Operative treatment recommended is suture control of bleeding, plus vagotomy and pyloroplasty as for an adult with similar presentation.

Acute Disease↗
PubMed1979

Studies on the maternal immune response to placental antigens: absence of a blocking factor from the blood of abortion-prone women.

The leucocyte migration-inhibition assay was employed to assess the reactivity of cells from postpartum women to placental antigen preparations. Leucocytes from normal primigravidae responded to their own placental antigens and displayed a limited degree of cross-reactivity with allogeneic preparations. Autologous plasma suppressed this antigen recognition and the factor responsible was shown to be an IgG antibody. Leucocytes from five women with spontaneous abortions also responded to autologous placental preparations but no immunosuppressive factor could be detected in their blood. It is suggested that target antigens for maternal lymphocytes are present on the placenta, a structure critical to the continuance of pregnancy, and that the presence of the blocking antibody is necessary for fetal well-being.

Abortion, Habitual↗
PubMedDate not supplied

Effect of beta blockade on singing performance.

The symptoms associated with performance anxiety, or the so-called stage fright syndrome, are similar to those of alpha and beta adrenergic stimulation. Suppression of symptoms and improvement in instrumentalist's performance after beta blockade suggest that this modality would be of benefit for singers as well. To evaluate the dose-effect relationship of beta blockade upon singing performance and the possible effect of these agents upon performance maturation, we studied 34 singing students during end of semester juries, using a double-blind crossover paradigm. Students performed once with either placebo, 20, 40, or 80 mg of nadolol, and again 48 hours later, with placebo. There was a significant dose-related, limiting effect upon intraperformance cardiac rate. A small, but statistically significant, dichotomous effect upon performance rating was noted: low-dose nadolol tended to enhance performance, whereas larger doses impaired performance. We conclude that the effects of low dose beta blockade upon singing are minimally helpful and high doses may detract from performance ability.

Adolescent↗
PubMedDate not supplied

Care of long-term central venous catheters.

Meticulous techniques in the use and handling of central venous catheters are an essential requirement for extended catheter longevity and low morbidity. Such techniques and protocols are described in this article.

Asepsis↗