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Biomedical subjects

A Severini

Publications and source records attributed to A Severini.

98 records · Page 6Linked to original sources
PubMedDate not supplied

Esophageal carcinoma. Radiologic appearance of minimal lesions.

Twelve minimal lesions were found over a period of 18 months at the Istituto Nazionale Tumori of Milan at the end of the radiologic, endoscopic and histologic procedures. Eleven lesions were radiologically detected, and a radiologic diagnosis of malignancy was perspectively made in 10 of the identified lesions. The radiologic aspects of minimal lesions are described. Double contrast study of the esophagus allows excellent mucosal detail and good reproduction of lesions. Simplicity and minimal discomfort for the patient justify it as a first diagnostic step for detection of neoplastic pathology.

Adult↗
PubMedDate not supplied

[Diagnostic imaging and interventional radiology in abdominal abscess formations].

Abdominal abscesses as a complication of laparotomic surgery have a high mortality rate. The authors reviewed the diagnostic and therapeutic procedures of 36 patients who developed intra-abdominal abscesses after surgical treatment for abdominal neoplasias. The first-step diagnostic procedures (plain film of the abdomen and chest, CT and US) showed a sensibility of 78%. In 25/36 patients (69.5%) two interventional radiology procedures were performed: fine needle aspiration and catheter drainage of the abscess. In 16% of patients fine needle aspiration led to a complete evacuation of the abscess cavity and guaranteed the recovery. In 84% of cases a drainage catheter was positioned into the cavity and left indwelling. This case review is aimed at stressing how plain film of the abdomen is still a diagnostic procedure with high sensibility and specificity for this pathology, even though it is currently considered as a second-choice diagnostic step--US and CT being assessed as the methodologies of choice. The latter techniques can both provide a more accurate imaging when interventional radiology procedures are to be performed.

Abdomen↗
PubMedDate not supplied

[Transcutaneous radiotherapy combined with low dose intraluminal brachytherapy in the treatment of non-operable neoplastic stenoses of the bile ducts].

Percutaneous biliary drainage is an excellent method to relieve the acute symptoms related to neoplastic stenoses of extrahepatic bile ducts. However, survival rates are low and the quality of life of these patients is poor. High dose irradiation--combined with external beams (ERT) and intraluminal brachytherapy (BRT) through percutaneous drainage--allows effective disease control and, therefore, not only higher survival rates but also a much better quality of life when drainage can be removed after bile duct stenosis resolution. March, 1990, through March, 1993, eleven patients (8 with extrahepatic cholangiocarcinomas and 3 with extrinsic tumors) were treated with combined ERT (40-60 Gy, 6-15 MV X-rays) and intraluminal BRT (6-25 Gy, 192Ir wire, LDR). In 8 patients the biliary stenosis was resolved, completely (CR) in 5 and partially (PR) in 3, as shown by posttreatment cholangiography. In 5 patients biliary drainage could be removed for an average 9 months' period; 3 of 11 patients did not respond to treatment at all (NR). Average overall survival was 14 months: 11 months for NR patients and 16.5 months for CR+PR patients. Treatment complications were acceptable: in two patients only treatment had to be discontinued, both during BRT. Two cases of high grade postirradiation stenosis were observed, both resolved with percutaneous cholangioplasthy.

Aged↗
PubMedDate not supplied

[Use of safety catheter after removal of Kehr's tube in liver transplant patients].

The authors report on the use of a safety catheter when removing the T-tube in the patients with choledocho-choledochal biliary reconstruction after liver transplantation. After T-tube removal, bile may leak into the peritoneal cavity through the catheter insertion site in the biliary wall. Biliary peritonitis, bilomas, subhepatic collections may develop, which are difficult to treat in immunodepressed patients. The safety catheter is used to allow the external drainage of the biliary outflow, if present, and to prevent the complications due to bile collecting in the peritoneal cavity. Moreover, the catheter allows cholangiography and interventional procedures to be performed when necessary. A soft guidewire is inserted into the distal bile duct through the T-tube and pushed into the duodenum. After removing the T-tube, an 8.3-F all-purpose catheter (APD) is placed on the guidewire with the tip just outside the biliary wall. The APD is then connected to a drainage bag allowing the amount of bile eliminated daily to be checked. This maneuver was performed in 24 transplant recipients and the safety catheter correctly positioned in 22 of them (91.6%). The APD was removed 48 hours after insertion in 15 patients with no biliary leakage. In the remaining 7 patients the catheter was left in situ up to 8 days, since biliary leakage was observed (range: 50-400 ml/day). No early or late complications related to this technique were observed.

Anastomosis, Surgical↗
PubMedDate not supplied

Comparative in vitro sensitivity of human cholangiocarcinoma and colon adenocarcinoma cells to anticancer agents.

We comparatively investigated the sensitivity of a human cholangiocarcinoma cell line (SG231) and an adenocarcinoma cell line (WiDr) to mitoxantrone (MX), taxol (TX), mitomycin C (MMC), doxorubicin (DX), cisplatin (CDDP) and 5-fluorouracil (5FU) by the sulforhodamine B assay. The lower susceptibility of SG231 to SFU, to CDDP, to DX and to MMC than WiDr was observed, whereas the sensitivity of the two cell lines to MX and TX was similar. We also investigated the ability of a chemical modulator, lonidomine (LND), and hyperthermia to enhance the cytotoxic activity of the different drugs in the SG231 cell line. No potentiation of MX or CDDP activity was observed after a 2 hours treatment in hyperthermic conditions (42 degrees C). Conversely, a slight potentiation of a 2 hours pretreatment with MX and DX was obtained by a 24 hours post treatment with LND.

Adenocarcinoma↗