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Biomedical subjects

A Senning

Publications and source records attributed to A Senning.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Novel Bis-sulfonic Acid Esters with Cytostatic Activity (author's transl)].

The introduction of electron-withdrawing groups into the group R of piposulfan analogs R--SO2--O--X--O--SO2--R substantially increases their antileukemic activity in animal tests (leukemia L 1210). The central moiety X can be varied considerably (provided it contains amide groups) without appreciable loss of activity. A number of busulfan analogs as well as busulfan itself proved to be practically inactive against murine leukemia L 1210. Among a total of 122 bis-sulfonic acid esters tested 35 gave a survival time index of 150% or more after i.p. application and 5 after oral application.

Alkylating Agents↗
PubMed1976

[Late results of surgery in muscular subvalvular aortic stenosis].

Pre- and postoperative clinical and hemodynamic findings of 35 patients operated for hypertrophic obstructive cardiomyopathy are presented. One early death and three av-blocks necessitating a permanent pacemaker have to be mentioned as surgical complications. In all cases, an outflow tract obstruction was abolished or greatly diminished and symptoms disappeared or were considerably improved. Two patients died after recurrence of congestive heart failure during the late follow-up. Furthermore, the occurrence of reappearance of different arrhythmias up to 10 years postoperatively are evidence of the progression of the disease despite of surgical treatment. Sudden death has not occurred in a total of 150 patient-years of postoperative follow-up. Thus, the operation abolishes the stenosis and relieves symptoms; on the other hand, it cannot be stated to what degree surgery improves the prognosis.

Adolescent↗
PubMed1976

Psychomotor and intellectual development after deep hypothermia and circulatory arrest in early infancy.

Somatic, psychomotor, and intellectual development were studied in 11 patients who had total correction of congenital cardiac malformation in early infancy by the method of surface-induced deep hypothermia and circulatory arrest up to 43 minutes. Time between operation and re-evaluation ranged from 3 to 11 years (average 7 years). Somatic development was normal in all children. Psychomotor and intellectual behavior, measured by a battery of specially adapted test methods, failed to show a statistically significant difference when compared between the study group, a matched control group, and the normal population. Normal scores in psychomotor tests and normal intelligence quotients (I.Q.) were present in 8 patients; mental retardation was found in 2 patients: and unstable behavior, evident from different tests, was present in one. Except for the last case, in none of the patients was the method was found to be the primary cause of the abnormal behavior. Deep hypothermia and circulatory arrest in early infancy does not appear to have a negative influence on somatic, psychomotor, or intellectual development.

Anthropometry↗
PubMed1975

[Proceedings: Surgical closure of an atrial septal defect in a patient of over 40 years of age].

Between 1961 and 1972, 354 patients with atrial septal defect were treated surgically. Of these, 80 patients were aged over 40 years at the time of operation. The hospital mortality was 5%; 2 patients had increased preoperative pulmonary artery systolic pressure (50-75 mm Hg), while the other 2 had mitral or tricuspid incompetence. At late follow-up 82% of patients were free of symptoms and 18% had slight clinical signs of breathlessness on exertion. The heart size decreased in 37 of 10 patients, the electrocardiographic signs of right ventricular hypertrophy receded in 23 patients. The operation had no effect on preexisting dysrhythmias. It is concluded that patients with atrial septal defect in this age group benefit from surgical closure of the defect.

Adult↗
PubMed1975

[Proceedings: Results of early surgery in infectious endocarditis].

23 patients with infective endocarditis have been treated surgically during the period 1965 to 1975. 20 patients underwent operation for intractable heart failure, complicated in 4 instances by systemic embolization and in 4 others by intractable infection. Two patients were operated upon only for intractable infection and one patient for severe hemolysis. There were 5 early deaths within 12 days and 2 late deaths 2 and 21 months after operation. Four months to 9 1/2 years after operation 16 patients were alive, only one of whom had mild heart failure. The best prognosis (1 death) was apparent in the 12 patients who underwent operation for intractable heart failure only.

Adult↗
PubMed1975

[The effect of aneurysm resection on left ventricular function].

The effect of successful aortocoronary artery bypass surgery on left ventricular (LV) function was studied by angiography in 13 patients with coronary-artery disease and resection of a ventricular aneurysm. The following were calculated from single-plane right anterior oblique LV cine-angiograms: LV end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), percentage shortening of the medial perpendicular short axis (deltaM), mean velocity shortening of the circumferential fibres (VCF). The changes in the five hemi-axes of the anterior LV wall, and five of the inferior wall were averaged to give a value for relative anterior wall motion (SMV) and inferior wall motion (SMH). Changes in apical motion (SMS) were calculated from the percentage changes in the base-to-apex axis. The following mean values (x plus or minus s) were obtained four months before and 11 months after aneurysmectomy: EDVI (ml/m2) 154 plus or minus 27 (126 plus or minus 23), ESVI (ml/m2) 107 plus or minus 28 (56 plus or minus 15), SVI (ML/M2) 46.5 plus or minus 12.7 (69.9 plus or minus 23.1), EF (%) 32.6 plus or minus 8.0 (54.6 plus or minus 12.0), SMV (%) 6.1 plus or minus 10.0 (25.0 plus or minus 13.4), SMH (%) 25.9 plus or minus 13.1 (31.2 plus or minus 11.1), SMS (%) 5.1 PLus or minus 3.4 (13.1 plus or minus 4.2). These results indicated significant improvement in ventricular pumping action and wall motion after aneurysm resection and aortacoronary bypass surgery in patients with coronary-artery disease and severe cardiac failure.

Adult↗
PubMed1975

[Late results of replacement of the antrio-ventricular valve].

From 1966 to 1969 mitral-valve-allografts have been implanted for mitral valve replacement in 11 and for tricuspid valve replacement in two patients. Three patients died immediately after the operation. Eigth allografts in mitral position and one in tricuspid position functioned well. One case was complicated by candida albicans. There were no thromboembolic complications. Long-term follow up revealed late deterioration of allograft function in every case. Four allografts have been replaced four are still functioning four to six years postoperatively. Because of the poor durability of the results this method of mitral valve replacement is not used any more.

Adult↗
PubMed1975

[Transposition of great vessels].

Venous inflow stenoses either pulmonary or systemic represents a major complication after Mustard's operation. In order to eliminate such stenoses two modified methods of atrial in version have been developed using no or a minimum of foreign material. The indication for each method is different. Both methods have the incorporation of the remaining atrial septum and of a part of the left atrial wall into the new septum in common. The midportion is completed using a small Dacron patch in cases with fragile atrial tissue (method I) or a flap of the rightatrial wall in cases with normal tissue (method II). The incorporation of growing tissue into the new atrial septum minimizes the risk of secondary stenoses, due to shrinkage or excessive apposition of fibrous pannus.

Child↗
PubMed1975

[Evaluation of the interaction between blood and foreign material in the pump oxygenator during open-heart surgery in infants by scanning electron microscopy (author's transl)].

Scanning electron microscopy was used to elucidate the interaction between blood and foreign material in the pump oxygenator during open-heart surgery in 7 infants. The loss of platelets upstream of the blood pump is caused by thrombogenicity. The pump itself causes massive destruction of platelets and red blood cells; thromboembolie up to 100 mu and foreign body particles up to 200 mu are being detached from the wall of the tubing to a large extent. The particulate matter is trapped in arterial line filter. Particles up to 40 mu and cellular aggregates up to 60 mu can pass through the filter and enter the patient's systemic circulation.

Blood↗
PubMed1975

Correction of the transposition of the great arteries.

Inversion of the atrial flow in transposition of the great arteries is achieved in the following way: the remaining atrial septum is detached from behind, leaving it as a flap between both AV-valves. The incision is continued into the coronary sinus and the Vena magna cordis to the base of the left atrial appendage along the mitral ring. The resulting flap from the split coronary sinus is sutured to the left atrial wall in front of the left side pulmonary veins, thus forming a septum dorsal to the caval veins, diverting the left pulmonary venous blood to the right side. The atrial septal flap is reattached in front of the caval vein orifices. In 50 cases a small Dacron patch was used to complete the midportion of the new septum. Six patients died and so far we have encountered one superior Vena cava stenosis and one pulmonary vein stenosis. In 16 patients completion of the midportion of the new atrial septum was done with a partially excised flap from the right atrial wall still attached to the Vena cava inferior. This method resulted in 3 operative deaths. In 42 of 58 survivors the ECG has been repeatedly controlled 3 months to 6 years postoperatively. Thirty-six of the 42 patients have sinus rhythm, 4 vary between nodal and sinus-rhythm and 2 have a total AV-dissociation.

Child↗