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Biomedical subjects

A Senning

Publications and source records attributed to A Senning.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Early scanning electron microscopy changes of the surface of the leaflets of orthotopic transplanted glyceraldehyd-conditioned conus-pulmonalis xenografts. An experimental study in dogs].

The surface of the leaflets of orthotopic transplanted glutaraldehyd-conditioned conus-pulmonalis xenografts show when analysed by a scanning microscope the following constant changes. Within seconds the surface of the leaflets is covered by a grainy layer of proteins followed by fibrin threads. Cellular elements of the blood--like platelets, white blood cells, macrophages and microthrombi--are incorporated in the fibrin network. This leads, after several weeks to a fibrous layer especially over the stiff parts of the valve. No endothelium was seen even after 6 months.

Animals↗
PubMed1978

[Bronchopulmonary hamartomas, chondromas, fibromas and myxomas].

The observation of 23 bronchopulmonary hamartomas, 9 chondromas, one fibroma and one myxoma has provided insight into the particularities of these tumors. The group of hamartomas, tumors of "erroneous mixture of tissue", included 20 cases which can be considered a malformation of the entodermal bronchial anlage, and 3 cases which can be regarded as a malformation of the mesenchymal anlage. The first type consists of multiple cleft-like spaces surrounded by ciliated and cuboidal epithelium. There are no alveolar cells. Cartilaginous, fibrous, myxomatous and lipomatous tissue and lymphocytes are also found. The second type consists mainly of undifferentiated mesenchymal cells with tubules, lined by cuboidal epithelial cells or an intestinal type of mucus-secreting epithelium. There may be some immature alveoli, but no ciliated epithelium is found. In contrast to the hamartomas, the chondromas are not derived from a dysontogenetic malformation of the bronchopulmonary tissue but are tumors which develop directly from the bronchial cartilage and are for this reason mainly localized in the endobronchial region. A special form seen in one case is association of pulmonary chondromas, gastric leiomyomas or leiosarcomas and extra-adrenal paraganglioma, though the latter is not always present.

Adult↗
PubMed1978

[The Bjoerk-Shiley and the Lillehei-Kaster valve in aortal position. A hemodynamic comparison].

Thirty-two patients with tilting disc valves in the aortic position were evaluated by left heart catheterization and cineangiography. 24 patients had Björk-Shiley valves (B-S group) and 8 Lillehei-Kaster valves (L-K group). At the postoperative hemodynamic evaluation, left ventricular peak systolic pressure was significantly (p less than 0.001) higher in the L-K group (174 +/- 22 mm Hg) than in the B-S group (140 +/- 22 mm Hg). The mean systolic pressure gradient across the prosthesis was significantly (p less than 0.001) higher in the L-K group (34 mm Hg) than in the B-S group (12 mm Hg). The calculated valve area at a similar average tissue annulus diameter was significantly smaller in the L-K group (0.9 cm2) than in the B-S group (1.5 cm2). It is concluded (1) that in the aortic position at similar external prosthesis dimensions the B-S valve exhibits superior hemodynamic performance of the L-K valve and (2) that aortic valve replacement by L-K valve is associated with significant postoperative left ventricular pressure load.

Aortic Valve↗
PubMed1978

[Bronchial and subpleural lipoma (author's transl)].

Three cases of bronchopulmonary lipomas are reported, two sub pleural and one endobronchial. They represent 2,8% of all so-called benign bronchopulmonary tumours in our statistic. The two subpleural and asymptomatic lipomas were treated by thoracotomy and enucleation, the third, the endobronchial lipoma required lobectomy because of irreversible pulmonary damage.

Adult↗
PubMed1978

[Surgical treatment of active infective endocarditis (author's transl)].

Between 1965 and 1976 40 patients underwent valve replacement for active, infective endocarditis. The overall mortality rate was 32,5 per cent. Six patients died early (within 30 days) and 7 within the following 8 years. 11 patients developed paravalvular leckage. Eight of these 11 patients required reoperation. We suggest that all patients with active infective endocarditis who develop progressive heart failure, intractable sepsis or recurrent embolization should be subject to immediate valve replacement despite higher operative risk.

Adult↗
PubMed1978

[Clinical application of paracorporeal artificial ventricles (author's transl)].

A pneumatically driven artificial heart with tubular silicone rubber membrane and disc valves was used in four patients with intractable postoperative cardiac failure. The operation was performed through a median sternotomy: large cannulas were placed in both atria and blood was returned to aorta and pulmonary artery. In three patients the natural heart recovered and the artificial ventricles were removed. One patient died 6 weeks after the operation, the other two left the hospital in good condition. Profound postoperative heart failure can be reversed by the use of the paracorporeal artificial heart; the advantage of the system lies in the simplicity of its implantation and removal.

Evaluation Studies as Topic↗
PubMed1978

Paracorporeal artificial heart in postoperative heart failure.

A pneumatically driven artificial heart with a tubular silicone rubber membrane and disc valves was used for functional heart replacement in the paracorporeal mode. A fluidic drive system allows adjustment of the heart rate, positive and negative pressures and systole/diastole ratio. Since August, 1977, the artificial heart has been used in four patients with refractory postoperative heart failure not responding to volume loading, pH and electrolyte correction, catecholamines and intra-aortic balloon pumping. Large cannulae were placed in the atria and great vessels. The ventricles were fixed on the chest paracorporeally. The assist system was used as a left heart bypass in one patient and as a biventricular bypass in three other patients. After 48-72 hours, the ventricular function recovered in three patients, permitting removal of the artificial heart. One patient died of cerebral complications six weeks later; the other two recovered completely and were released in good condition. Profound postoperative heart failure can be completely reversed by the use of the paracorporeal artificial heart; the advantage of the system lies in the simplicity of its implantation and removal.

Adolescent↗
PubMed1978

[Stomach perforation and other complications after splenectomy].

The complications of 151 cases of splenectomy are analyzed, the methods of their prevention discussed. As a special complication two cases of gastric fistula following splenectomy are reported. As prevention we recommend several broad Lembert sutures to invert the entire danger zone.

Gastric Fistula↗
PubMed1977

[10 years survival of kidney grafts].

Prior to the end of June 1967, a total of 22 kidney allotransplantations had been performed at the Kantonsspital Zurich, Switzerland, with the exclusive use of cadaver kidneys. Ten years later, 10 patients are still alive, 8 of them with functioning primary transplant. In none of these patients is the serum creatinine higher than 1.6 mg%. 6 of the 8 patients are at work full-time and 2 half-time.

ABO Blood-Group System↗
PubMed1977

[Surgical treatment of myocardial aneurysms. Indications and results].

The long term results of 95 left ventricular aneurysmectomies are presented. In 47 patients simultaneous aorto-coronary bypass surgery was performed. 53 patients presented preoperatively with congestive heart failure; 8 out of these died within the first postoperative month, while 5-year survival rate (actuarial method) was 52%. Two thirds of this patient group improved. None of the 42 patients without preoperative congestive heart failure died early. 5-year survival rate was 93% and subjective improvement was recorded in one half of this subgroup. Comparison of pre- and postoperative angiograms (40 patients) revealed an increase in left ventricular ejection fraction reflecting the removal of the non-contracting segment. The ejection fraction of the contracting segment of the left ventricle improved after aneurysmectomy, especially in patients with preoperative congestive heart failure. In conclusion, aneurysmectomy improves left ventricular function and the symptoms of heart failure; moreover, it prevents perforation of false aneurysms. Its effect on arrhythmias could not be determined conclusively. Angina may be improved by simultaneous aorto-coronary bypass surgery.

Angina Pectoris↗
PubMed1977

[2 years of clinical experiences with lithium pacemakers].

Between January 1974 and December 1976, 470 mercury-cell pacemakers and 353 lithium-cell pacemakers were implanted at Surgical Clinic A of the University Hospital of Zurich. Within the first 24 months 15.5% of the mercury-cell pacemakers had to be exchanged because of premature battery depletion and 1.3% due to dysfunction of electronic components. None of the lithium-cell pacemakers had to be removed for these reasons. In 6 lithium-cell pacemakers, however, overhaul was necessary because of sensing failure. One unit had to be removed after one year for local decubitus. In two cases, repositioning of the batteries was necessary because of local muscle stimulation.

Humans↗
PubMed1977

[Liver resection in benign and malignant tumors].

Benign tumors of the liver, circumscribed hepatomas and solitary hepatic metastases from colonic cancer are treated by partial liver resection. In case of colonic cancer the hepatic metastasis is resected in a second operation. 20 cases of hepatic resections are reported. 10 right hepatic lobectomies, 1 left hepatic lobectomy and 9 minor resections were performed. Of the 11 patients treated by hepatic lobectomy, one (or 9%) died in the postoperative period (within 30 days after operation). Of the other 9 patients undergoing minor resections there was no death.

Carcinoma, Hepatocellular↗