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Biomedical subjects

A Senn

Publications and source records attributed to A Senn.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Chronic arterial occlusive disease of the lower body. Diagnostic-therapeutic, especially surgical-therapeutic aspects and postoperative care].

The treatment of chronic arterial circulatory disorders of the lower extremities depends on the one hand on the presence of a type of occlusive process which can be confirmed angiologically and on the other hand by the degree of severity and thirdly on the availability of operative and conservative methods of treatment. According to the stage of ischemia (Stage III and IV) possibly only surgical measures offer the possibility of preventing amputation. The nearer the stenotic process to the aorta, the greater the possibility of success of a surgical intervention if the general condition does not represent a contraindication to surgery. The questions of indications for operation and the problems of the most suitable procedure (endarterectomy, bypass, prostheses, Dotter's transluminal dilatation) are discussed on the basis of many years' experience.

Aorta, Abdominal↗
PubMed1979

Genetic heterogeneity in osteogenesis imperfecta.

An epidemiological and genetical study of osteogenesis imperfecta (OI) in Victoria, Australia confirmed that there are at least four distinct syndromes at present called OI. The largest group of patients showed autosomal dominant inheritance of osteoporosis leading to fractures and distinctly blue sclerae. A large proportion of adults had presenile deafness or a family history of presenile conductive hearing loss. A second group, who comprised the majority of newborns with neonatal fractures, all died before or soon after birth. These had characteristic broad, crumpled femora and beaded ribs in skeletal x-rays. Autosomal recessive inheritance was likely for some, if not all, of these cases. A third group, two thirds of whom had fractures at birth, showed severe progressive deformity of limbs and spine. The density of scleral blueness appeared less than that seen in the first group of patients and approximated that seen in normal children and adults. Moreover, the blueness appeared to decrease with age. All patients in this group were sporadic cases. The mode of inheritance was not resolved by the study, but it is likely that the group is heterogeneous with both dominant and recessive genotypes responsible for the syndrome. The fourth group of patients showed dominant inheritance of osteoporosis leading to fractures, with variable deformity of long bones, but normal sclerae.

Adolescent↗
PubMed1979

[Determination of the conditions of extra-anatomical arterial cross-over-shunts].

Extra anatomical cross-over-shunts are feasible even when the lending extremity is itself afflicted by obliterative arterial disease provided that 1. global irrigation of the lending extremity exceeds perfusion of the borrowing extremity, 2. pulse-volume-recording (PVR) corresponds to categories 1--3 as defined by Raines, 3. ankle pressure of the lending extremity is not less than 70 mm of mercury or 4. ankle pressure of the leading extremity corresponds to 60% or more than the systemic blood pressure.

Arterial Occlusive Diseases↗
PubMed1977

[Aneurysm of the abdominal aorta. Diagnostic, prognostic, and the therapeutic knowledge after review of cases and the literature].

Report on 80 patients with aneurysm of the abdominal aorta seen in this clinic during the period January 1968 to December 1974. They are divided into three groups, viz. asymptomatic, symptomatic and ruptured. The indication for and urgency of surgery are discussed and the results in 62 surgical cases are compared with those in 18 where surgery was not performed. The difficulties encountered in the diagnosis of ruptured aneurysm of the abdominal aorta are outlined. Only in these cases can the prognosis still be decisively improved by early recognition and immediate treatment.

Adult↗
PubMed1976

[Lung neoplasms in the Berne region. Epidemiology and smoking habit, compared to histology].

223 lung cancer patients were observed from June 1974 to April 1976. The diagnosis was by histology (after biopsy, operation or autopsy). There were 125 (56%) squamous cell carcinomas (sqcc), 42 (19%) small cell carcinomas (smcc), 27 (12%) large cell carcinomas (lacc) and 29 (13%) adenocarcinomas (adec). There were only 6 women (2.7%) in the series (3adec, 2 smcc and 1 lacc). Heavy and very heavy smokers were common in each group; smoking habits--even of patients with adec - differed markedly (p less than 0.0005) from those of an age and sex matched control group of 90 asthmatic patients with atopy. Sqcc patients were evenly distributed over the rural and urban zones of our region. But smcc, lacc and adec were more often seen coming from urban zones (p less than 0.0025). The whole lung cancer group was divided into a small group of 6 non-smokers (2.7%), into a 6.7% group of 15 pipe smokers, into a large group of 69 cigar smokers (30.9%) and into a final group of 133 (59.6%) cigarette smokers. The cigar smokers usually had sqcc (p less than 0.0005). The cancer of cigar smokers is more often a central lesion than a peripheral one (p less than 0.025). A history of repeated airway infections on the one hand, and severe airway infection at the beginning of lung cancer history on the other, are a more frequent association in cigar smokers than in cigarette smokers (p less than 0.01). Therefore, the lung cancer of cigar smokers is especially difficult to recognize. Cigar smoking appears to be just as important a link in the chain of causative factors leading to lung cancer as cigarette smoking.

Adenocarcinoma↗