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Biomedical subjects

A Sell

Publications and source records attributed to A Sell.

At least 55 records · Page 3Linked to original sources
PubMed1983

An epidemiological study of bladder cancer in a predominantly rural district.

A case-control study was performed on 212 bladder cancer patients (165 male + 47 female) and 259 control persons (165 male + 94 female) matched according to age and geographic area. Twenty-five determinants of assumed importance were examined. Bivariate analysis revealed a significantly increased relative risk (RR) of developing bladder cancer associated with cigarette smoking, cigarillos smoking, pipe smoking, tobacco chewing, industrial work, previous venereal disease, work with petroleum or asphalt, consumption of alcohol, work with oil or gasoline, and work with chemical materials. A multivariate logistic analysis showed that cigarette and cigarillos smoking involved the highest significant risks. An analogous logistic analysis of the negatively associated determinants revealed never smokers and farmers to be the weakest independent variables.

Adult↗
PubMed1982

An epidemiological case-control study of bladder cancer in males from a predominantly rural district.

A case-control study was performed on 165 male bladder cancer patients and an equal number of male control persons matched in age and geographic area. Thirty determinants of assumed importance were examined. A multivariate logistic analysis was performed. A significant increment in the relative risk (RR) for bladder cancer was associated with cigarette smoking (RR = 1.89), a history of prostatic surgery (RR = 2.38), nocturia (RR = 2.05), previous venereal disease (RR = 2.42), industrial work (RR = 1.82), work with oil or gasoline (RR = 2.71) and work with various unspecified chemical materials (RR = 1.58).

Adult↗
PubMed1982

Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: interim report from a randomized multicentre study.

The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate-below 10% in 221 patients-permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.

Clinical Trials as Topic↗
PubMed1979

Flow cytometric investigations of human bladder carcinoma compared to histological classification.

The DNA distribution has been investigated in biopsies from human bladder carcinomas by means of flow cytometry (FCM). The FCM analysis was based on a preparation method yielding a suspension of single cell nuclei. Biopsies from 45 patients were analysed. The results demonstrate a correlation between the degree of cellular anaplasia and the occurrence of cell populations with increased DNA content in the tumours. Cells with diploid DNA content constituted more than 90% of well-differentiated tumours and normal bladder mucosa. Cell populations with aneuploid DNA content occurred in almost all biopsies with cellular anaplasia estimated as grades II and III by microscopic examination. The results indicate that FCM analysis may be a valuable adjunct to histology. The possible prognostic significance of altered DNA distribution in bladder tumours is discussed.

Cytological Techniques↗
PubMed1979

DNA distribution in biopsy specimens from human cervical carcinoma investigated by flow cytometry.

Flow cytometry was used for the investigation of the DNA distribution in biopsy specimens from 51 patients with cervical carcinoma. Portio biopsy specimens from 9 pregnant women and from 10 patients with cancer of the breast served as controls. The results demonstrate that most specimens from patients suffering from cervical carcinoma contain considerable cell populations with increased DNA as compared with controls. The possible clinical significance of these findings is discussed.

Biopsy↗
PubMed1979

Correlation of DNA distribution and cytological differentiation of human cervical carcinomas.

The DNA distribution of biopsy specimens from 46 patients suffering from cervical carcinoma was analysed by flow cytometry and compared with the cytological differentiation. According to morphological criteria the carcinomas were classified as highly differentiated, moderately differentiated and poorly differentiated. The results demonstrate that highly differentiated tumours contain hyperploid cells predominantly with hyperdiploid DNA content. Hyperploid cell populations in the moderately differentiated tumours are mainly in the hyperdiploid and tetraploid regions. Poorly differentiated tumours contain hypertetraploid and aneuploid cell populations. The significance of these findings is discussed.

Biopsy↗
PubMed1979

Lack of radiation protective effect of orgotein in normal and malignant mammalian cells.

The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.

Animals↗
PubMed1979

Nephroblastoma. Results and complications of treatment.

Treatment results in 31 patients with nephroblastoma are reported. Survival seemed superior in patients who received Actinomycin-D in addition to surgery and postoperative irradiation. Twelve long-term surviving children were evaluated for side-effects of the treatment. Although inhibition of growth and other abnormalities occurred in most survivors, little permanent disability and dysfunction appears to have resulted from the treatment.

Adipose Tissue↗
PubMed1978

Serum alpha-fetoprotein and human chorionic gonadotropin as markers for the effect of postoperative radiation therapy and/or chemotherapy in testicular cancer.

Human alpha1-fetoprotein (AFP) and chroiongonadotropin (hCG) have been studied in 67 patients with malignant germ cell neoplasia of the testis admitted to the Radium Centre, Aarhus Municipal Hospital within an 18 month period. In 34 patients with nonseminoma, AFP was elevated in 35% of cases and hCG in 38% of cases. Nonseminoma patients who presented with or developed distant metastases showed a significantly higher incidence of elevated tumor markers than patients with local or regional disease. In patients with distant metastases monitoring of AFP and/or hCG was a most sensitive and reliable indicator of disease activity. In the management of such patients these tests are as important as clinical and x-ray examinations.

Antineoplastic Agents↗
PubMed1976

Serum alpha-fetoprotein as a marker for the effect of post-operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour.

The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological exmination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, endometriosis, and a dermoid cyst were also found. Six patients had increased serum alpha-fetoprotein concentration in the post-operative period, and two patients had a normal concentration 27 and 35 days after operation, respectively. In all cases except one, a close correlation between serum alpha-fetoprotein and progression or regression of tumour was found. Serum alphafetoprotein was thus found to be a reliable parameter in post-operative radiation and/or chemotherapy (VAMBLE). In one patient who died 10 months after operation with widespread endodermal sinus tumour growth, only a small terminal increase in serum alpha-fetoprotein concentration was found. Four of the eight women are still alive with normal alpha-fetoprotein concentration, and without clinical evidence of tumour disease.

Adolescent↗